|本期目录/Table of Contents|

[1]李志乐,韦秋宇,言纬,等.L-瓜氨酸对缺血再灌注损伤心肌的保护作用 及机制研究[J].国际心血管病杂志,2022,03:164-168,175.
　LI Zhile,WEI Qiuyu,YAN Wei,et al.Protective effect and mechanism of L-citrulline on myocardial ischemia-reperfusion injury[J].International Journal of Cardiovascular Disease,2022,03:164-168,175.
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L-瓜氨酸对缺血再灌注损伤心肌的保护作用 及机制研究(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2022年03期
页码:
164-168,175
栏目:
基础研究
出版日期:
2022-06-20

文章信息/Info

Title:
Protective effect and mechanism of L-citrulline on myocardial ischemia-reperfusion injury
作者:
李志乐; 韦秋宇; 言纬; 刘燕; 韦宝敏; 黄照河
533000 百色，右江民族医学院附属医院心血管内科
Author(s):
LI Zhile;  WEI Qiuyu;  YAN Wei;  LIU Yan;  WEI Baomin;  HUANG Zhaohe
Department of Cardiovascular Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China
关键词:
L- 瓜氨酸; 心肌缺血再灌注损伤; 心肌细胞凋亡; 心肌梗死
Keywords:
L-citrulline; Myocardial ischemia reperfusion injury; Myocardial apoptosis; Myocardial infarction
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2022.03.009
文献标识码:
-
摘要:
目的：探讨L- 瓜氨酸对缺血再灌注损伤心肌的保护作用及机制。方法：选取健 康新西兰大白兔30 只，随机分为对照组、模型组和实验组，每组10 只。构建MIRI 模型，实 验组予L- 瓜氨酸100 μg/L 预处理，模型组给予等量生理盐水，对照组只开胸不结扎。收集 各组血液和心肌组织标本，采用全自动生化分析仪检测血清肌酸激酶（CK）、肌酸激酶同工 酶（CK-MB）和乳酸脱氢酶（LDH）水平，苏木精- 伊红（HE）染色观察心肌病理学改变， 2,3,5- 三苯基氯化四氮唑（TTC）染色检测心肌梗死面积，原位末端转
Abstract:
Objectives: To investigate the protective effect and mechanism of L-citrulline on myocardial ischemia reperfusion injury (MIRI). Methods: A total of 30 healthy New Zealand white rabbits were randomly divided into sham operation group (control group), isch

参考文献/References

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81860797）；右江民族医学院附属医院高层次人才科研项目（Y20196318）
通信作者：黄照河, E-mail: bshuangzhaohe@163.com
更新日期/Last Update: 2022-06-20