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《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:

2022年03期

页码:

157-163

栏目:

基础研究

出版日期:

2022-06-20

文章信息/Info

Title:

Quercetin alleviates ventricular remodeling after myocardial infarction by up regulating sirit1

作者:

陈凯; 董静; 赵学飞

712000 咸阳， 陕西中医药大学第二附属医院心内科

Author(s):

CHEN Kai;  DONG Jing;  ZHAO Xuefei

Department of Cardiology, Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang 712000

关键词:

槲皮素; 沉默信息调控因子1 ; 心肌梗死; 心室重构; 细胞凋亡; 自噬

Keywords:

Quercetin;  Silent information regulatory factor 1;  Myocardial infarction;  Ventricular remodeling;  Apoptosis;  Autophagy

分类号:

-

DOI:

10.3969/j.issn.1673-6583.2022.03.008

文献标识码:

-

摘要:

目的：探讨槲皮素（Que）对心肌梗死（心梗）后心室重构的作用及机制。方法： 建立大鼠心梗模型，随机分为心梗组、Que 组、沉默信息调控因子1（Sirt1）抑制剂EX527 组、Que＋EX527 组，每组10 只，另取10 只大鼠设为假手术组。各组进行对应药物处理后， 检测大鼠血流动力学指标、心脏质量参数，苏木精- 伊红（HE）染色观察大鼠心肌组织形态 学， Masson 染色观察大鼠心肌组织纤维化，原位末端转移酶标记技术（TUNEL）检测大鼠 心肌细胞凋亡，Western blot 法检测大鼠心肌组织中

Abstract:

Objective: To investigate the effect and mechanism of quercetin (Que) on ventricular remodeling after myocardial infarction (MI). Methods: The MI rat model was established and randomly divided into model group (MI group), Que group, EX527 (Sirt1 inhibitor

参考文献/References

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备注/Memo

备注/Memo:

基金项目：陕西省科技厅重点研发项目（2020SF-277）
通信作者：赵学飞，E-mail: 251669799@qq.com

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更新日期/Last Update: 2022-06-20