|本期目录/Table of Contents|

[1]廖荣恒,祁禛,汪永义.RhoA/ROCK2通路在心脏成纤维细胞分化中的作用机制[J].国际心血管病杂志,2021,06:365-369.
　LIAO Rongheng,QI Zhen,WANG Yongyi.Mechanism of RhoA/ROCK2 pathway in cardiac fibroblasts differentiation[J].International Journal of Cardiovascular Disease,2021,06:365-369.
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RhoA/ROCK2通路在心脏成纤维细胞分化中的作用机制(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2021年06期
页码:
365-369
栏目:
基础研究
出版日期:
2021-12-01

文章信息/Info

Title:
Mechanism of RhoA/ROCK2 pathway in cardiac fibroblasts differentiation
作者:
廖荣恒; 祁禛; 汪永义
200001 上海交通大学医学院附属仁济医院心血管外科
Author(s):
LIAO Rongheng;  QI Zhen;  WANG Yongyi
Department of Cardiovascular Surgery, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
关键词:
心肌梗死;  RhoA/ROCK2通路;  心脏纤维化;  心脏成纤维细胞分化
Keywords:
Myocardiac infarction;  RhoA/ROCK2 pathway;  Myocardial fibrosis;  Cardiac fibroblasts differentiation
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2021.06.012
文献标识码:
-
摘要:
目的:探讨RhoA/ROCK2通路在急性心肌梗死(AMI)后心脏成纤维细胞分化过程中的作用机制。方法:选取12只清洁级6～8周龄雄性C57小鼠,随机平均分为AMI组与假手术组,AMI组开胸结扎左前降支,假手术组仅作开胸处理。21 d后处死小鼠取心脏组织,通过免疫组织化学技术分别对比梗死区与正常区域RhoA与ROCK2表达情况,运用实时荧光定量聚合酶链反应(qRT-PCR)及Western blot技术检测组织匀浆中RhoA与ROCK2表达情况。体外培养人心肌成纤维细胞,随机分为
Abstract:
Objective:To elucidate the effect and mechanism of RhoA/ROCK2 pathway on cardiac fibroblasts differentiation after acute myocardial infarction(AMI).Methods:Twelve clean male C57 mice, aged 6-8 weeks, were divided randomly into AMI group and sham group. Li

参考文献/References

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备注/Memo

备注/Memo:
通信作者:汪永义,E-mail:wangyongyi77@163.com
更新日期/Last Update: 2021-12-01