|本期目录/Table of Contents|

[1]周依蒙,郑鹏翔,戴晓勇,等.微小RNA-678调控心肌梗死相关转录因子FoxP1的表达研究[J].国际心血管病杂志,2018,01:44-47.
　ZHOU Yimeng,ZHENG Pengxiang,DAI Xiaoyong,et al.Myocardial infarction-related expression of transcription factor FoxP1 regulated by microRNA-678[J].International Journal of Cardiovascular Disease,2018,01:44-47.
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微小RNA-678调控心肌梗死相关转录因子FoxP1的表达研究(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2018年01期
页码:
44-47
栏目:
基础研究
出版日期:
2018-01-25

文章信息/Info

Title:
Myocardial infarction-related expression of transcription factor FoxP1 regulated by microRNA-678
作者:
周依蒙; 郑鹏翔; 戴晓勇; 华玮
200090 上海,同济大学附属杨浦医院心内科(周依蒙,郑鹏翔); 急诊科(戴晓勇,华玮)
Author(s):
ZHOU Yimeng1; ZHENG Pengxiang1;  DAI Xiaoyong2;  HUA Wei2.
1. Department of Cardiology, 2. Department of Emergency Medicine, Yangpu Hospital, School of Medicine, Tongji University,Shanghai 200090, China
关键词:
心肌梗死;  微小RNA;  微小RNA-678;  FoxP1
Keywords:
Myocardial infarction;  microRNA;  miR-678;  FoxP1
分类号:
-
DOI:
10.3969/j.issn.1673-534X.2018.01.012
文献标识码:
-
摘要:
目的:探索心肌梗死相关微小RNA(microRNA, miR)-678的功能及其调控的下游靶基因。方法:利用H2C9心肌细胞建立缺血缺氧模型,研究H2C9细胞氧糖剥夺后miR-678的表达; 利用细胞转染技术过表达miR-678,检测H2C9细胞增殖情况; 在microRNA数据库中,寻找miR-678可能结合的下游靶基因的3’非编码序列,并利用细胞转染技术在H2C9细胞中导入外源性miR-678模拟物或者抑制剂,验证miR-678对靶基因的调控。结果: miR-678可促进H2C9细胞增殖,在心肌细胞缺
Abstract:
Objective:To study the function of miR-678 related to myocardial infarction(MI)and the downstream target genes regulated by it.Methods:We investigated the expression of miR-678 after deprivation of oxygen and glucose, using the ischemic model of H2C9 card

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备注/Memo

备注/Memo:
基金项目:上海市卫生和计划生育委员会(20134376)
更新日期/Last Update: 2018-04-01