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[1]田家齐,黎明江,吴限,等.N-乙酰半胱氨酸对血管紧张素Ⅱ致成纤维细胞增殖及纤维连接蛋白表达的作用研究[J].国际心血管病杂志,2018,01:39-43.
　TIAN Jiaqi,LI Mingjiang,WU Xian,et al.Effects of N-acetylcysteine on angiotensinⅡ-induced proliferation and fibronectin expression of fibroblasts[J].International Journal of Cardiovascular Disease,2018,01:39-43.
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N-乙酰半胱氨酸对血管紧张素Ⅱ致成纤维细胞增殖及纤维连接蛋白表达的作用研究(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2018年01期
页码:
39-43
栏目:
基础研究
出版日期:
2018-01-25

文章信息/Info

Title:
Effects of N-acetylcysteine on angiotensinⅡ-induced proliferation and fibronectin expression of fibroblasts
作者:
田家齐; 黎明江; 吴限; 黄亚敏
431900 湖北省钟祥市人民医院心内科(田家齐); 430060 武汉大学人民医院心内科(黎明江,吴限,黄亚敏)
Author(s):
TIAN Jiaqi1;  LI Mingjiang2;  WU Xian2;  HUANG Yamin2.
1. Department of Cardiology, Zhongxiang People’s Hospital of Hubei Province, Zhongxiang Hospital of Renmin Hospital of Wuhan University, Hubei 431900; 2. Department of Cardiology, Remin Hospital of Wuhan University, Hubei 430060, China
关键词:
成纤维细胞;  纤维化;  N-乙酰半胱氨酸;  血管紧张素Ⅱ
Keywords:
Cardiac fibroblasts;  Fibrosis;  N-acetylcysteine;  AngiotensinⅡ
分类号:
-
DOI:
10.3969/j.issn.1673-534X.2018.01.011
文献标识码:
-
摘要:
目的:探讨不同浓度N-乙酰半胱氨酸(NAC)对血管紧张素Ⅱ致成纤维细胞(CFs)增殖及纤维连接蛋白(FN)表达的影响。方法:分离培养1～3日龄SD大鼠乳鼠的CFs,分组加入不同浓度的血管紧张素Ⅱ(AngⅡ)及NAC进行干预。1组加入普通培养基(含10% FBS的DMEM培养液); 2组在普通培养基中加入终浓度为2.5×10-7 μmol/L 的AngⅡ; 3组在普通培养基中加入终浓度为5.0×10-7 μmol/L的AngⅡ; 4组在普通培养
Abstract:
Objective:To investigate the effects of different concentrations of N-acetylcysteine(NAC)on angiotensinⅡ(AngⅡ)-induced proliferation and fibronectin(FN)expression of fibroblasts(CFs).Methods:The CFs were isolated and cultured from 1 day to 3 days old Spra

参考文献/References

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[11] 刘卫青, 张晓晔, 朱敏, 等. N-乙酰半胱氨酸对博莱霉素致小鼠肺间质纤维化形成及NF-κB、IL-4表达的影响[J]. 郑州大学学报(医学版), 2013, 48(1):43-46.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81170085)通信作者:黎明江,Email:mingjiangli@yahoo.com.cn
更新日期/Last Update: 2018-04-01