索引超出了数组界限。 文章摘要
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[1]高洁,顾刚,陆林,等.C1q肿瘤坏死因子相关蛋白4研究进展[J].国际心血管病杂志,2016,02:99-101.
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C1q肿瘤坏死因子相关蛋白4研究进展(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2016年02期
页码:
99-101
栏目:
综述
出版日期:
2016-03-20

文章信息/Info

Title:
-
作者:
高洁; 顾刚; 陆林; 王晓群
200025,上海交通大学医学院附属瑞金医院心脏科
Author(s):
-
关键词:
C1q肿瘤坏死因子相关蛋白4; 动脉粥样硬化; 肿瘤
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2016.02.011
文献标识码:
-
摘要:
C1q肿瘤坏死因子相关蛋白(C1q/tumornecrosisfactor-relatedproteins,CTRPs)是一类新发现的蛋白超家族,与脂联素具有高度同源性。CTRPs组织分布广泛,生物学功能多样,参与调节物质代谢、血管壁细胞功能、血小板聚集、炎性反应等。CTRP4是该家族成员之一,其结构特殊,包含2个球状C1q结构域,缺乏胶原结构域。CTRP4对肿瘤、代谢、炎症及心血管疾病有重要调节作用。该文介绍CTRP4的结构特点、分布表达及其生物学功能。
Abstract:
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参考文献/References

[1] Wong GW, Wang J, Hug C, et al. A family of Acrp30/adiponectin structural and functional paralog [J]. Proc Natl Acad Sci U S A, 2004, 101(28): 10302-10307.
[2] Wong GW,Krawczyk SA, Kitidis-Mitrokostas C, et al. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions[J]. Biochem J, 2008, 416(2): 161-177.
[3] Peterson JM, Wei Z, Wong GW. CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members[J]. Biochem Biophys Res Commun, 2009, 388(2): 360-365.
[4] Wei Z, Peterson JM, Wong GW. Metabolic regulation by C1q/TNF-related protein-13(CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling[J]. J Biol Chem, 2011, 286(18): 15652-15665.
[5] Kishore U,Gaboriaud C, Waters P, et al. C1q and tumor necrosis factor superfamily: modularity and versatility[J]. Trends Immunol, 2004, 25(10): 551-561.
[6] Peterson JM,Seldin MM, Tan SY, et al. CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice[J]. PLoS One, 2014, 9(2): 01-09.
[7] Peterson JM, Wei Z, Wong GW.C1q/TNF-related protein-3(CTRP3), a noveladipokine that regulates hepatic glucose output[J]. J Biol Chem, 2010, 285(51): 39691-39701.
[8] Hofmann C, Chen N,Obermeier F, et al. C1q/TNF-related protein-3(CTRP-3)is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts[J]. Inflamm Bowel Dis, 2011, 17(12): 2462-2471.
[9] Kopp A,Bala M, Buechler C,et al. C1q/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue[J]. Endocrinology, 2010, 151(11): 5267-5278.
[10] Kopp A,Bala M, Weigert J, et al. Effects of the new adiponectin paralogous protein CTRP-3 and of LPS on cytokine release from monocytes of patients with type 2 diabetes mellitus[J]. Cytokine, 2010, 49(1): 51-57.
[11] 那达祥, 马 壮, 罗 阳, 等.脂肪细胞因子CTRP4转基因鼠的构建与鉴定[J].中国比较医学杂志, 2014, 24(7): 1671-7856.
[12] Seldin MM, Tan SY, Wong GW.Metabolic function of the CTRP family of hormones[J]. Rev Endocr Metab Disord.2014, 15(2):111-123.
[13] Jeon JH, Kim KY, Kim JH,et al. A novel adipokine CTRP1 stimulates aldosterone production[J]. FASEB J,2008, 22(5):1502-1511.
[14] Chalupova L, Zakovska A, Adamcova K. Development of a novel enzyme-linked immuosorbent assay(ELISA)for measurement of serum CTRP1:a pilot study:measurement of serum CTRP1 in heathy donors and patients with metabolic syndrome[J]. Clin biochem,2013,46(1-2):73-78.
[15] Pan X, Lu T, Wu F et al. Circulating complement-C1q TNF-related protein 1 levels are increased in patients with type2 diabetes and are associated with insulin sentivity in Chinese subjects[J]. PLoS One 2014, 9(5):01-06.
[16] Lu L, Zhang RY, WangXQ,et al. C1q TNF-related protein 1: an adipokine marking and promoting atherosclerosis[J]. Eur Heart, 2015, Dec 24.pii:ehv649.
[17] 李春明,陆 林,陈秋静,等. 血清CTRP9水平与冠心病的关系[J].国际心血管病杂志 2013, 40(5):323-325.
[18] Jung CH, Lee MJ, Kang YM et al.C1q/TNF-related protein-9 inhibits cytokine-induced vascular inflammation and leukocyte adhesiveness via AMP-activated protein kinase activation in endothelial cells[J]. Mol Cell Endocrinol,2016, 419(5):235-243.
[19] 刘珠慧,陆 林,沈卫峰 CTRP蛋白家族与动脉粥样硬化[J]. 国际心血管病杂志, 2013, 40(02): 85-87.
[20] 谭伟峰, 王兰兰, 李 琦, 等. 人类新基因CTRP4的原核表达及多克隆抗体的制备[J]. 细胞与分子免疫学杂志, 2012, 28(06): 614-617+622.
[21] Li Q, Wang L, Tan W, et al. Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-kappaB pathways and promotes cell survival in human cancer cells[J]. Cancer Lett, 2011, 308(2): 203-214.
[22] Grivennikov S, Karin E, Terzic J, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer[J]. Cancer Cell, 2009,15(2): 103-113.
[23] Xia Y,Shen S, Verma IM. NF-kappaB, an active player in human cancers[J]. Cancer immunol res 2014, 2(9):823-830.
[24] Yu H, Lee H, Herrmann A, et al. Revisiting STAT3 signalling in cancer: new and unexpected biological functions[J]. Nat rev Cancer 2014, 14(11):736-746.
[25] Byerly MS, Petersen PS, Ramamurthy S, et al. C1q/TNF-related protein 4(CTRP4)is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight[J]. J Biol Chem, 2014, 289(7): 4055-4069.
[26] 孟 华,陆 林,张瑞岩,等. 炎症因子CTRP1血清水平与冠心病的研究[J]. 国际心血管病杂志, 2012, 39(04): 242-244.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金青年项目(81400211) 作者单位:200025,上海交通大学医学院附属瑞金医院心脏科 通信作者:顾 刚,Email:gugang@medmail.com
更新日期/Last Update: 2016-03-20