索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]张文,付炜,张海波.G蛋白偶联雌激素受体在心血管疾病中的作用[J].国际心血管病杂志,2016,02:96-98.
点击复制

G蛋白偶联雌激素受体在心血管疾病中的作用(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2016年02期
页码:
96-98
栏目:
综述
出版日期:
2016-03-20

文章信息/Info

Title:
-
作者:
张文; 付炜; 张海波
200127 上海交通大学医学院附属上海儿童医学中心心胸外科
Author(s):
-
关键词:
雌激素; G蛋白偶联雌激素受体; 心血管疾病
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2016.02.010
文献标识码:
-
摘要:
流行病学研究发现雌激素可能在心血管系统中起保护作用,但绝经后的女性雌激素替代治疗的临床效果却不尽如人意。G蛋白偶联雌激素受体(Gprotein-coupledestrogenreceptor,GPER)是一种能介导快速非基因组效应的新型雌激素受体,体内外研究发现它能参与心室重构、血压调节、脂代谢和动脉粥样硬化的进程,有望成为心血管疾病预防与治疗的新靶点。
Abstract:
-

参考文献/References

[1] Ostadal B, Ostadal P. Sex-based differences in cardiac ischaemic injury and protection: therapeutic implications[J]. Br J Pharmacol, 2014, 171(3):541-554.
[2] Boardman HM, Hartley L, Eisinga A, et al. Hormone therapy for preventing cardiovascular disease in post-menopausal women[J]. Cochrane Database Syst Rev, 2015, 3:CD002229.
[3] Prossnitz ER, Barton M. The G-protein-coupled estrogen receptor GPER in health and disease[J]. Nat Rev Endocrinol, 2011, 7(12):715-726.
[4] Recchia AG, De Francesco EM, Vivacqua A, et al. The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha(HIF-1alpha)in breast cancer cells and cardiomyocytes[J]. J Biol Chem, 2011, 286(12):10773-10782.
[5] Wang H, Zhao Z, Lin M,et al. Activation of GPR30 inhibits cardiac fibroblast proliferation[J]. Mol Cell Biochem, 2015, 405(1-2):135-148.
[6] Meyer MR, Fredette NC, Howard TA, et al. G protein-coupled estrogen receptor protects from atherosclerosis[J]. Sci Rep, 2014, 4:7564.
[7] Li F, Yu X, Szynkarski CK,et al. Activation of GPER induces differentiation and inhibition of coronary artery smooth muscle cell proliferation[J]. PLoS One, 2013, 8(6):e64771.
[8] Cheng SB, Quinn JA, Graeber CT, et al. Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway[J]. J Biol Chem, 2011, 286(25):22441-22455.
[9] Chakrabarti S, Davidge ST. G-protein coupled receptor 30(GPR30): a novel regulator of endothelial inflammation[J]. PLoS One, 2012, 7(12):e52357.
[10] Samartzis EP, Noske A, Meisel A,et al. The G protein-coupled estrogen receptor(GPER)is expressed in two different subcellular localizations reflecting distinct tumor properties in breast cancer[J]. PLoS One, 2014, 9(1):e83296.
[11] Prossnitz ER, Arterburn JB. Internationalunion of basic and clinical pharmacology. XCVII. G protein-coupled estrogen receptor and its pharmacologic modulators[J]. Pharmacol Rev, 2015, 67(3):505-540.
[12] Prossnitz ER, Hathaway HJ. What have we learned about GPER function in physiology and disease from knockout mice?[J]. J Steroid Biochem Mol Biol, 2015, 153:114-126.
[13] Filardo EJ, Quinn JA, Frackelton AR Jr, et al. Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis[J]. Mol Endocrinol, 2002, 16(1):70-84.
[14] Lindsey SH, Liu L, Chappell MC. Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling[J]. Steroids, 2014, 81:99-102.
[15] Meyer MR, Amann K, Field AS, et al. Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction[J]. Hypertension, 2012, 59(2):507-512.
[16] Albanito L, Madeo A, Lappano R, et al. G protein-coupled receptor 30(GPR30)mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells[J]. Cancer Res, 2007, 67(4):1859-1866.
[17] Vivacqua A, Bonofiglio D, Albanito L, et al. 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30[J]. Mol Pharmacol, 2006, 70(4):1414-1423.
[18] Li WL, Xiang W, Ping Y. Activation of novel estrogen receptor GPER results in inhibition of cardiocyte apoptosis and cardioprotection[J]. Mol Med Rep, 2015, 12(2):2425-2430.
[19] Weil BR, Manukyan MC, Herrmann JL, et al.Signaling via GPR30 protects the myocardium from ischemia/reperfusion injury[J]. Surgery, 2010, 148(2):436-443.
[20] Kabir ME, Singh H, Lu R,et al. G protein-coupled estrogen receptor 1 mediates acute estrogen-induced cardioprotection via MEK/ERK/GSK-3beta pathway after ischemia/reperfusion[J]. PLoS One, 2015, 10(9):e0135988.
[21] Wang H, Jessup JA, Lin MS,et al. Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodelling in oophorectomized mRen2.Lewis rats[J]. Cardiovasc Res, 2012, 94(1):96-104.
[22] Lee TM, Lin SZ, Chang NC.Both GPER and membrane oestrogen receptor-alpha activation protect ventricular remodelling in 17beta oestradiol-treated ovariectomized infarcted rats[J]. J Cell Mol Med, 2014, 18(12):2454-2465.
[23] Maric-Bilkan C, Gilbert EL, Ryan MJ. Impact of ovarian function on cardiovascular health in women: focus on hypertension[J]. Int J Womens Health, 2014, 6:131-139.
[24] Lindsey SH, da Silva AS, Silva MS, et al. Reduced vasorelaxation to estradiol and G-1 in aged female and adult male rats is associated with GPR30 downregulation[J]. Am J Physiol Endocrinol Metab, 2013, 305(1):E113-E118.
[25] Feldman RD, Gros R, Ding Q, et al. A common hypofunctional genetic variant of GPER is associated with increased blood pressure in women[J]. Br J Clin Pharmacol, 2014, 78(6):1441-1452.
[26] Meyer MR, Field AS, Kanagy NL,et al. GPER regulates endothelin-dependent vascular tone and intracellular calcium[J]. Life Sci, 2012, 91(13-14):623-627.
[27] Hussain Y, Ding Q, Connelly PW, et al. G-protein estrogen receptor as a regulator of low-density lipoprotein cholesterol metabolism: cellular and population genetic studies[J]. Arterioscler Thromb Vasc Biol, 2015, 35(1):213-221.
[28] Meoli L, Isensee J, Zazzu V, et al.Sex- and age-dependent effects of Gpr30 genetic deletion on the metabolic and cardiovascular profiles of diet-induced obese mice[J]. Gene, 2014, 540(2):210-216.
[29] Sharma G, Hu C, Brigman JL,et al. GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state[J]. Endocrinology, 2013, 154(11):4136-4145.

备注/Memo

备注/Memo:
通信作者:张海波,Email: zhanghaibosh@126.com
更新日期/Last Update: 2016-03-20