[1]邓聪颖,曹海涛.环状RNA，在心血管疾病中的发病机制及临床应用[J].国际心血管病杂志,2022,01:21-24.
点击复制
环状RNA，在心血管疾病中的发病机制及临床应用(PDF)
《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]
- 期数:
- 2022年01期
- 页码:
- 21-24
- 栏目:
- 综述
- 出版日期:
- 2022-02-10
文章信息/Info
- Title:
- -
- Author(s):
- -
- Keywords:
- -
- 分类号:
- -
- DOI:
- 10.3969/j.issn.1673-6583.2022.01.006
- 文献标识码:
- -
- 摘要:
- 环状RNA（circRNA）在细胞中广泛存在且稳定表达，可作为重要的调控元件 充当微小RNA 和RNA 结合蛋白的海绵，参与调控转录、翻译、剪切等过程，影响心脏炎性 反应信号通路、血管平滑肌细胞功能、心肌细胞肥厚与凋亡、脂质代谢等过程。该文介绍 了circRNA 心血管疾病早期诊断、治疗靶点、风险分层的基本特点。
- Abstract:
- -
参考文献/References
[1] Wang Y, Liu B. Circular RNA in diseased heart[J]. Cells,
2020, 9(5):1240.
[2] Zang J, Lu D, Xu A. The interaction of circRNAs and RNA
binding proteins: an important part of circRNA maintenance
and function[J]. J Neurosci Res, 2020, 98(1):87-97.
[3] Zhu L, Li N, Sun L, et al. Non-coding RNAs: the key detectors
and regulators in cardiovascular disease[J]. Genomics, 2021,
113(1 Pt 2):1233-1246.
[4] Jiang C, Zeng X, Shan R, et al. The emerging picture of the
roles of circRNA-CDR1as in cancer[J]. Front Cell Dev Biol,
2020, 8:590478.
[5] Du WW, Yang W, Chen Y, et al. Foxo3 circular RNA promotes
cardiac senescence by modulating multiple factors associated
with stress and senescence responses[J]. Eur Heart J, 2017,
38(18):1402-1412.
[6] Yang Q, Li F, He AT, et al. Circular RNAs: expression,
localization, and therapeutic potentials[J]. Mol Ther, 2021,
29(5):1683-1702.
[7] Kong P, Yu Y, Wang L, et al. circ-Sirt1 controls NF-kappaB
activation via sequence-specific interaction and enhancement
of SIRT1 expression by binding to miR-132/212 in vascular
smooth muscle cells[J]. Nucleic Acids Res. 2019, 47(7): 3580-
3593.
[8] Huang HS, Huang XY, Yu HZ, et al. Circular RNA circ-
RELL1 regulates inflammatory response by miR-6873-3p/
MyD88/NF-κB axis in endothelial cells[J]. Biochem Biophys
Res Commun, 2020, 525(2):512-519.
[9] Cheng J, Liu Q, Hu N, et al. Downregulation of hsa_
ci rc_0068087 amel iorates TLR4/NF-κB/NLRP3
inflammasome-mediated inflammation and endothelial cell
dysfunction in high glucose conditioned by sponging miR-
197[J]. Gene, 2019, 709:1-7.
[10] He X, Bao X, Tao Z, et al. The microarray identification
circular RNA hsa_circ_0105015 up-regulated involving
inflammation pathway in essential hypertension[J]. J Clin Lab
Anal. 2021, 35(2): e23603.
[11] Hall IF, Climent M, Quintavalle M, et al. Circ_Lrp6, a circular
RNA enriched in vascular smooth muscle cells, acts as a
sponge regulating miRNA-145 function[J]. Circ Res, 2019,
124(4):498-510.
[12] Chen J, Cui L, Yuan J, et al. Circular RNA WDR77 target
FGF-2 to regulate vascular smooth muscle cells proliferation
and migration by sponging miR-124[J]. Biochem Biophys Res
Commun, 2017 , 494(1-2):126-132.
[13] Fasolo F, Di Gregoli K, Maegdefessel L, et al. Non-coding
RNAs in cardiovascular cell biology and atherosclerosis[J].
Cardiovasc Res, 2019, 115(12):1732-1756.
[14] Wang K, Long B, Liu F, et al. A circular RNA protects the
heart from pathological hypertrophy and heart failure by
targeting miR-223[J]. Eur Heart J, 2016, 37(33):2602-2611.
[15] Sun J, Zhang Z, Yang S. Circ_RUSC2 upregulates the
expression of miR-661 target gene SYK and regulates the
function of vascular smooth muscle cells[J]. Biochem Cell
Biol, 2019, 97(6):709-714.
[16] Tan WL, Lim BT, Anene-Nzelu CG, et al. A landscape of
circular RNA expression in the human heart[J]. Cardiovasc
Res, 2017, 113(3):298-309.
[17] Lei W, Feng T, Fang X, et al. Signature of circular RNAs
in human induced pluripotent stem cells and derived
cardiomyocytes[J]. Stem Cell Res Ther, 2018, 9 (1):56.
[18] Fang X, Cai Z, Wang H, et al. Loss of cardiac ferritin H
facilitates cardiomyopathy via Slc7a11-mediated ferroptosis[J].
Circ Res, 2020, 127(4):486-501.
[19] Hu X, Ma R, Cao J, et al. CircSAMD4A aggravates
H/R-induced cardiomyocyte apoptosis and inflammatory
response by sponging miR-138-5p[J]. J Cell Mol Med, 2020
Nov 21. [Epub ahead of print].
[20] Wang L, Zheng Z, Feng X, et al. circRNA/lncRNA-miRNAmRNA
network in oxidized, low-density, lipoprotein-induced
foam cells[J]. DNA Cell Biol, 2019, 38(12):1499-1511.
[21] Liu Y, Liu H, Li Y, et al. Circular RNA SAMD4A controls
adipogenesis in obesity through the miR-138-5p/EZH2 axis[J].
Theranostics, 2020, 10(10):4705-4719.
[22] Yu G, Yang Z, Peng T, et al. Circular RNAs: rising stars in
lipid metabolism and lipid disorders[J]. J Cell Physiol. 2021,
236(7):4797-4806.
[23] Zhao Z, Li X, Gao C, et al. Peripheral blood circular RNA
hsa_circ_0124644 can be used as a diagnostic biomarker of
coronary artery disease[J]. Sci Rep, 2017, 7:39918.
[24] Vilades D, Martínez-Camblor P, Ferrero-Gregori A, et al.
Plasma circular RNA hsa_circ_0001445 and coronary artery
disease: Performance as a biomarker[J]. FASEB J, 2020,
34(3):4403-4414.
[25] Sun Y, Chen R, Lin S, et al. Association of circular RNAs
and environmental risk factors with coronary heart disease[J].
BMC Cardiovasc Disord, 2019, 19(1):223.
[26] Sun C, Ni M, Song B, et al. Circulating circular RNAs:
novel biomarkers for heart failure[J]. Front Pharmacol, 2020,
11:560537.
[27] Bazan HA, Hatfield SA, Brug A, et al. Carotid plaque
rupture is accompanied by an increase in the ratio of serum
circR-284 to miR-221 levels[J]. Circ Cardiovasc Genet, 2017,
10(4):e001720.
[28] Wu N, Jin L, Cai J. Profiling and bioinformatics analyses
reveal differential circular RNA expression in hypertensive
patients[J]. Clin Exp Hypertens, 2017, 39(5):454-459.
[29] Zheng S, Gu T, Bao X, et al. Circular RNA hsa_circ_0014243
may serve as a diagnostic biomarker for essential
hypertension[J]. Exp Ther Med, 2019, 17(3):1728-1736.
[30] Wu J, Li J, Liu H, et al. Circulating plasma circular RNAs as
novel diagnostic biomarkers for congenital heart disease in
children[J]. J Clin Lab Anal, 2019, 33(9):e22998.
[31] Sonnenschein K, Wilczek AL, de Gonzalo-Calvo D, et al.
Serum circular RNAs act as blood-based biomarkers for
hypertrophic obstructive cardiomyopathy[J]. Sci Rep, 2019,
9(1):20350.
[32] Wang K, Gan TY, Li N, et al. Circular RNA mediates
cardiomyocyte death via miRNA-dependent upregulation of
MTP18 expression[J]. Cell Death Differ, 2017, 24(6):1111-
1120.
[33] Garikipati VNS, Verma SK, Cheng Z, et al. Circular RNA
circFndc3b modulates cardiac repair after myocardial
infarction via FUS/VEGF-A axis[J]. Nat Commun, 2019,
10(1):4317.
[34] Lei D, Wang Y, Zhang L, et al. Circ_0010729 regulates
hypoxia-induced cardiomyocyte injuries by activating TRAF5
via sponging miR-27a-3p[J]. Life Sci, 2020, 262:118511.
[35] Deng Y, Wang J, Xie G, et al. Circ-HIPK3 strengthens the
effects of adrenaline in heart failure by miR-17-3p - ADCY6
axis[J]. Int J Biol Sci, 2019, 15(11):2484-2496.
[36] Salgado-Somoza A, Zhang L, Vausort M, et al. The circular
RNA MICRA for risk stratification after myocardial
infarction[J]. Int J Cardiol Heart Vasc, 2017, 17:33-36.
备注/Memo
- 备注/Memo:
-
基金项目：国家自然科学基金（8197021000）；江苏省江苏省卫生
健康委员会（Z2018031）
通信作者：曹海涛, E-mail:caohaitao718@sina.com
常用功能
统计/Statistics
- 摘要浏览/Viewed1
- 全文下载/Downloads324
- 评论/Comments
