|本期目录/Table of Contents|

[1]颜雯 张怡清 张焕基 廖欢 钟文清 杨美兰.雷米普利对病毒性心肌炎后心肌细胞凋亡水平的影响[J].国际心血管病杂志,2018,05:285-287.
　YAN Wen,ZHANG Yiqing,ZHANG Huanji,et al.Effects of ramipril on myocardial cell apoptosis after viral myocarditis[J].International Journal of Cardiovascular Disease,2018,05:285-287.
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雷米普利对病毒性心肌炎后心肌细胞凋亡水平的影响(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2018年05期
页码:
285-287
栏目:
基础研究
出版日期:
2019-02-01

文章信息/Info

Title:
Effects of ramipril on myocardial cell apoptosis after viral myocarditis
作者:
颜雯 张怡清 张焕基 廖欢 钟文清 杨美兰
Author(s):
YAN Wen1;  ZHANG Yiqing2;  ZHANG Huanji1;  LIAO Huan1;  ZHONG Wenqing1;  YANG Meilan1.
1. The Eighth Affiliated Hospital of Sun Yat-sen University, Guangdong 518033; 2. The Seventh Affiliated Hospital of Sun Yat-sen University, Guangdong 518000, China
关键词:
雷米普利;  病毒性心肌炎;  心肌细胞;  凋亡
Keywords:
Ramipril;  Viral myocarditis;  Myocardial cell;  Apoptosis
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2018.05.008
文献标识码:
-
摘要:
目的:探讨雷米普利对病毒性心肌炎后心肌细胞凋亡水平的影响。方法:采用CVB3感染BALB/c乳鼠原代心肌细胞,构建病毒性心肌炎模型。将细胞分为空白组、模型组、血管紧张素Ⅱ( Ang Ⅱ)组、AngⅡ+雷米普利组和雷米普利组。空白组正常培养心肌细胞72 h。其余4组以CVB3 100 PFU/cell的比例感染心肌细胞48 h,构建病毒性心肌细胞模型,模型组于培养液中加入PBS,Ang Ⅱ组于培养液中加入终浓度为100 nmol/L的AngⅡ,AngⅡ+雷米普利组于培养液中加入终浓度为100 nmol/L
Abstract:
Objective:To investigate the effects of ramipril on myocardial cell apoptosis after viral myocarditis.Methods:After extracting the primary cardiomyocytes of BALB/c sucking mice, CVB3 virus was infected for construction of viral cardiomyocyte model. The ca

参考文献/References


[1] Yu F, Chen R, Takahashi T, et al. Candesartan improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin[J]. Int J Cardiol, 2008, 129(3):414-421.
[2] Huang TF, Wu XH, Wang X, et al. Fas-FasL expression and myocardial cell apoptosis in patients with viral myocarditis[J]. Genet Mol Res, 2016, 15(2):15027607.
[3] Peng Y, Fu ZZ, Guo CS, et al. Effects and mechanism of baicalin on apoptosis of cervical cancer HeLa cells in-vitro[J]. Iran J Pharm Res, 2015,14(1):251-261.
[4] Lin L, Zhang M, Yan R, et al. Inhibition of Drp1 attenuates mitochondrial damage and myocardial injury in Coxsackievirus B3 induced myocarditis[J]. Biochem Biophys Res Commun, 2017, 484(3):550-556.
[5] Zhang X, Ha T, Lu C, et al. Poly(I:C)therapy decreases cerebral ischaemia/reperfusion injury via TLR3-mediated prevention of Fas/FADD interaction[J]. J Cell Mol Med, 2015, 19(3):555-565.

备注/Memo

备注/Memo:
基金项目:深圳市科创委资助项目(JCYJ20170818162010186)
作者单位:518033 深圳,中山大学附属第八医院(颜雯,张焕基,廖欢,钟文清,杨美兰); 518000 深圳,中山大学附
属第七医院(张怡清)
更新日期/Last Update: 2018-09-30