|本期目录/Table of Contents|

[1]刘旨浩,王宇虹,王钧,等.心肌梗死对比格犬左侧星状神经节时钟基因表达的影响[J].国际心血管病杂志,2022,06:363-366.
　LIU Zhihao,WANG Yuhong,WANG Jun,et al.Alterations in clock gene expression of left stellate ganglion indued by myocardial infarction in beagles[J].International Journal of Cardiovascular Disease,2022,06:363-366.
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心肌梗死对比格犬左侧星状神经节时钟基因表达的影响(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2022年06期
页码:
363-366
栏目:
基础研究
出版日期:
2022-12-20

文章信息/Info

Title:
Alterations in clock gene expression of left stellate ganglion indued by myocardial infarction in beagles
作者:
刘旨浩; 王宇虹; 王钧; 周慧鑫; 于中洋; 张嵩; 矫鹂莹; 聂鹂庆; 王悦怡; 江洪; 余锂镭
430060 武汉大学人民医院心内科，武汉大学心脏自主 神经研究中心，武汉大学心血管病研究所，心血管病湖北省重点实 验室
Author(s):
LIU Zhihao;  WANG Yuhong;  WANG Jun;  ZHOU Huixin;  YU Zhongyang;  ZHANG Song;  JIAO Liying;  NIE Liqing;  WANG Yueyi;  JIANG Hong;  YU Lilei
Department of Cardiology, Renmin Hospital of Wuhan University, Cardiac Autonomic Nervous System Research Center of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, China
关键词:
心肌梗死; 左侧星状神经节; 时钟基因; 昼夜节律
Keywords:
Myocardial infarction;  Left stellate ganglion;  Clock gene;  Circadian rhythm
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2022.06.013
文献标识码:
-
摘要:
目的：探究心肌梗死对比格犬左侧星状神经节（LSG）时钟基因表达的影响。 方 法：12 只成年比格犬随机分为心肌梗死组（MI 组）和对照组，每组6 只。2 组动物均于麻 醉后行左侧开胸术，暴露心脏，MI 组行左前降支结扎术，对照组仅开胸不结扎。造模1 h 后 分离各组LSG，行荧光实时定量聚合酶链反应检测核心时钟基因（Bmal1、Clock、Per1、 Per2、Cry1 和Cry2）及钟控基因（Nr1d1、Nr1d2、Rorα 和Tim）的mRNA 表达水平。 结 果：与对照组相比，MI 组LSG 中Per2、Nr1d1 的mRNA 表达水平显著降低，Cry1、Cry2、 Tim 的mRNA 表达水平显著升高（P 均＜0.05）。 结论：心肌梗死可引起LSG 中时钟基因 的表达异常，这可能与心肌梗死后猝死事件发生的昼夜节律有关。
Abstract:
Objective: To investigate the effect of myocardial infarction (MI) on clock gene expression in left stellate ganglion (LSG) of beagles. Methods: Twelve adult beagles were randomly divided into MI group (n＝6) and control group (n＝6). Left thoracotomy was p

参考文献/References

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81871486，81970287）
通信作者：余锂镭， E-mail：lileiyu@whu.edu.cn
更新日期/Last Update: 2022-12-20