|本期目录/Table of Contents|

[1]王勇,张瑞岩.移行上皮反应基因1蛋白调控巨噬细胞胆固醇 代谢作用研究[J].国际心血管病杂志,2022,04:223-227.
　WANG Yong,ZHANG Ruiyan.Effect of TERE1 protein on macrophage cholesterol metabolism[J].International Journal of Cardiovascular Disease,2022,04:223-227.
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移行上皮反应基因1蛋白调控巨噬细胞胆固醇 代谢作用研究(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2022年04期
页码:
223-227
栏目:
基础研究
出版日期:
2022-08-30

文章信息/Info

Title:
Effect of TERE1 protein on macrophage cholesterol metabolism
作者:
王勇; 张瑞岩
200072 上海交通大学医学院附属瑞金医院心内科
Author(s):
WANG Yong;  ZHANG Ruiyan
Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200072, China
关键词:
胆固醇; 巨噬细胞; 动脉粥样硬化; 移行上皮反应基因1
Keywords:
Cholesterol;  Macrophages;  Atherosclerosis;  Transitional epithelial response gene 1
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2022.04.009
文献标识码:
-
摘要:
目的：探讨移行上皮反应基因1（TERE1）蛋白对巨噬细胞胆固醇代谢的影 响及潜在的机制。 方法：以氧化低密度脂蛋白（ox-LDL）处理巨噬细胞RAW264.7，观察 TERE1 的蛋白和mRNA 表达水平变化。以TERE1 过表达慢病毒和TERE1 siRNA 分别建立 高或低表达TERE1 的巨噬细胞模型，分别测定ox-LDL 孵育后细胞内胆固醇含量变化。同 时，利用逆转录聚合酶链反应（RT-PCR）检测胆固醇转运因子的变化。 结果：ox-LDL 使 巨噬细胞TERE1 的mRNA 和蛋白表达水平显著增
Abstract:
Objectives: To assess the effect of TERE1 on macrophage cholesterol metabolism and its possible mechanism. Methods: RAW264.7 macrophage cells were treated with ox-LDL, and protein expression levels of TERE1 in macrophages was assessed. Lentivirus and TERE

参考文献/References

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备注/Memo

备注/Memo:
基金项目：中国博士后科学基金第56 批面上一等资助（2014M560346）
通信作者：王勇， Email: sulongwy@126.com
更新日期/Last Update: 2022-08-30