|本期目录/Table of Contents|

[1]韩丹,罗超迪,闫炀.风湿性二尖瓣疾病合并心房颤动患者心房纤维化 相关微小RNA-647及预测靶基因研究[J].国际心血管病杂志,2022,04:228-234.
　HAN Dan,LUO Chaodi,YAN Yang.Atrial fibrosis-related miR-647 and its predictive target genes in patients with rheumatic mitral valve disease and atrial fibrillation[J].International Journal of Cardiovascular Disease,2022,04:228-234.
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风湿性二尖瓣疾病合并心房颤动患者心房纤维化 相关微小RNA-647及预测靶基因研究(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2022年04期
页码:
228-234
栏目:
临床研究
出版日期:
2022-08-30

文章信息/Info

Title:
Atrial fibrosis-related miR-647 and its predictive target genes in patients with rheumatic mitral valve disease and atrial fibrillation
作者:
韩丹; 罗超迪; 闫炀
710061 西安交通大学第一附属医院心血管外科（韩丹，闫炀）；710061 西安交通大学第一附属医院心血管内科（罗超迪）
Author(s):
HAN Dan1;  LUO Chaodi2;  YAN Yang1
1. Department of Cardiovascular Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061; 2. Department of Cardiology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China
关键词:
心房颤动; 心房纤维化; 生物信息学; 微小RNA-647 ; PRKCA 基因
Keywords:
Atrial fibrillation;  Atrial fibrosis;  Bioinformatics;  MiR-647;  PRKCA gene
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2022.04.010
文献标识码:
-
摘要:
目的：明确风湿性二尖瓣疾病合并心房颤动（房颤）患者心房组织的主要病 理变化，生物信息学分析并筛选与风湿性二尖瓣疾病房颤患者心房纤维化相关的微小RNA （miRNA）及其靶基因。 方法：收集在西安交通大学第一附属医院行心脏外科手术治疗的 30 例风湿性二尖瓣疾病患者（窦性心律组10 例，房颤组20 例）的临床资料及心房样本。苏 木精- 伊红染色、Masson 染色、免疫组织化学染色后观察心房组织病理变化；实时定量聚合 酶链反应及Western blot 法检测纤维化相关蛋白和通路在心房组织中的表达；生物信息
Abstract:
Objective: To identify the main pathological changes of atrial tissue in patients with rheumatic mitral valve disease (RMVD) and atrial fibrillation (AF), and to analyze and screen miRNAs and their target genes associated with atrial fibrosis in patients

参考文献/References

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备注/Memo

备注/Memo:
基金项目：陕西省自然科学基础研究计划（2021JQ-394）
通信作者：闫炀， E-mail: yyang376@126.com
更新日期/Last Update: 2022-08-30