|本期目录/Table of Contents|

[1]阿燕·西合斯,罗健,邵明明,等.淋巴细胞连接蛋白调控JAK-STAT信号通路在高血压血管重构中 的作用[J].国际心血管病杂志,2021,03:168-173.
　Ayan·Xihesi,LUO Jian,SHAO Mingming,et al.The role of lymphocyte adaptor protein in regulating JAK-STAT signaling pathway in hypertensive vascular remodeling[J].International Journal of Cardiovascular Disease,2021,03:168-173.
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淋巴细胞连接蛋白调控JAK-STAT信号通路在高血压血管重构中 的作用(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2021年03期
页码:
168-173
栏目:
基础研究
出版日期:
2021-06-10

文章信息/Info

Title:
The role of lymphocyte adaptor protein in regulating JAK-STAT signaling pathway in hypertensive vascular remodeling
作者:
阿燕·西合斯; 罗健; 邵明明; 张玉玺; 张源明; 王凌鹏
830054 乌鲁木齐,新疆医科大学第一附属医院心力衰竭科
Author(s):
Ayan·Xihesi;  LUO Jian;  SHAO Mingming;  ZHANG Yuxi;  ZHANG Yuanming;  WANG Lingpeng
Department of Heart Failure, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
关键词:
高血压;  淋巴细胞连接蛋白;  Janus激酶;  信号转导与转录激活子;  血管重构
Keywords:
Hypertension;  Lymphocyte adaptor protein;  Janus kinase;  Signal transduction and transcriptional activator;  Vascular remodeling
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2021.03.011
文献标识码:
-
摘要:
目的:探讨淋巴细胞连接蛋白(LNK)调控Janus激酶(JAK)/信号转导与转录激活子(STAT)信号通路在高血压血管重构中的作用。方法:选取大鼠胸主动脉平滑肌细胞,构建高血压细胞模型。实验分组为对照组、 血管紧张素(Ang)Ⅱ组、AngⅡ+空载组、AngⅡ+LNK组。流式细胞仪检测血管平滑肌细胞(VSMC)的细胞周期、凋亡及增殖水平; 实时荧光定量聚合酶链反应检测各组LNK、JAK2、STAT3的mRNA表达水平; Western blot检测各组LNK、STAT3、磷酸化S
Abstract:
Objective:To investigate the role of lymphocyte adaptor protein(LNK)in regulating Janus kinase(JAK)/signal transduction and activators of transcription(STAT)signaling pathway in vascular remodeling in hypertension.Methods:Rat thoracic aortic smooth muscle

参考文献/References

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备注/Memo

备注/Memo:
基金项目:新疆维吾尔自治区科技支疆项目(2017E0268) 通信作者:王凌鹏,E-mail:dcwlp@163.com
更新日期/Last Update: 2021-06-10