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《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:

2021年03期

页码:

163-167

栏目:

基础研究

出版日期:

2021-06-10

文章信息/Info

Title:

Effects of aerobic exercise on remodeling of potassium channel in ventricular myocytes from rats with heart failure

作者:

胡菱; 孟林凤; 胥亚楠; 裴赫男; 王茜; 胡华刚; 赵冬琰; 刘梅洁

102211 北京小汤山医院(胡菱,孟林凤,胥亚楠,裴赫男,王茜,胡华刚,赵冬琰); 100700 北京,中国中医科学院动物实验中心 (刘梅洁)

Author(s):

HU Ling¹;  MENG Linfeng¹;  XU Yanan¹;  PEI Henan¹;  WANG Qian¹;  HU Huagang¹;  ZHAO Dongyan¹;  LIU Meijie²

1. Beijing Xiaotangshan Hospital, 102211 Beijing; 2. Experimental Research Center, China Academy of Chinese Medical Sciences, 100700 Beijing, China

关键词:

充血性心力衰竭;  心室重构;  有氧运动;  延迟整流钾离子通道

Keywords:

Congestive heart failure;  Ventricular remodeling;  Aerobic exercise;  Delayed rectifier potassium channel

分类号:

-

DOI:

10.3969/j.issn.1673-6583.2021.03.010

文献标识码:

-

摘要:

目的:探讨有氧运动(AE)对充血性心力衰竭(CHF)大鼠心室肌细胞钾通道重构的作用及机制。方法:将SD大鼠随机分为假手术组、CHF组、假手术+AE组、CHF+AE组。建立CHF及假手术大鼠模型后,4组大鼠先进行适应性训练1周,假手术组、CHF组进行一般照护8周,假手术+AE组和CHF+AE组给予AE干预8周。各组饲养及训练结束后行超声心动图检测左室射血分数(LVEF)及左室后壁厚度(LVPWD),HE染色、天狼星红染色检测心肌组织形态学及纤维化程度,计算左室质量指数(LVWI),定量分析N末端脑钠肽前体(

Abstract:

Objective:To investigate the effects and mechanism of aerobic exercise(AE)on remodeling of potassium channel in ventricular myocytes from rats with congestive heart failure(CHF).Methods:SD rats were randomly divided into sham operation(SO), CHF, SO+AE and

参考文献/References

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备注/Memo

备注/Memo:

基金项目:北京市医院管理局临床医学发展专项经费(ZYLX201835); 北京市自然科学基金(7192242) 通信作者:胥亚楠,E-mail:282984303@qq.com

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更新日期/Last Update: 2021-06-10