|本期目录/Table of Contents|

[1]孟哲颖 胡兵 陈翠 曹洪丽 王静怡 申锷.1型糖尿病小鼠心肌组织miR-142-3p的lncRNA和circRNA靶标分析[J].国际心血管病杂志,2018,04:214-218.
　MENG Zheying,HU Bing,CHEN Cui,et al.Bioinformatics analysis of lncRNA and circRNA targeting miR-142-3p in type 1 diabetic mice[J].International Journal of Cardiovascular Disease,2018,04:214-218.
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1型糖尿病小鼠心肌组织miR-142-3p的lncRNA和circRNA靶标分析(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2018年04期
页码:
214-218
栏目:
基础研究
出版日期:
2018-07-25

文章信息/Info

Title:
Bioinformatics analysis of lncRNA and circRNA targeting miR-142-3p in type 1 diabetic mice
作者:
孟哲颖 胡兵 陈翠 曹洪丽 王静怡 申锷
Author(s):
MENG Zheying1;  HU Bing1;  CHEN Cui1;  CAO Hongli2;  WANG Jingyi2;  SHEN E2
1.Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai 200233; 2.Department of Ultrasound in Medicine, Tongren Hospital, Shanghai Jiao Tong Universit
关键词:
糖尿病;  miR-142-3p;  心肌;  生物信息学
Keywords:
Diabetes;  MiR-142-3p;  Heart;  Bioinformatics
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2018.04.007
文献标识码:
-
摘要:
目的:利用生物信息学对1型糖尿病小鼠心肌组织中微小RNA(miR)-142-3p进行长链非编码RNA(lncRNA)和环状RNA(circRNA)靶标预测。方法:22只C57小鼠随机分为糖尿病模型组(n=15)和对照组(n=7),糖尿病模型组小鼠经腹腔一次性注射链脲佐菌素(STZ)建立1型糖尿病小鼠模型,对照组注射柠檬酸缓冲液。建模8周后终止实验,检测左室质量指数(LVWI)和心脏功能,HE染色结合定量分析软件检测心肌细胞大小; 通过miRNA表达谱芯片技术甄别miRNAs的
Abstract:
Objective:To predict new long non-coding RNA(lncRNA)and circular RNA(circRNA)targeting miR-142-3p in type 1 diabetic mice myocardium by bioinformatics.Methods:A total of 22 C57 mice were randomly divided into type 1 diabetes group(n=15)and control

参考文献/References


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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81270208); 上海市长宁区科学技术委员会重点项目(CNKW2017Z03)
作者单位:200233 上海交通大学附属第六人民医院超声医学科,上海超声医学研究所(孟哲颖,胡兵,陈翠); 200336
上海交通大学医学院附属同仁医院超声医学科(曹洪丽,王静怡,申锷)
更新日期/Last Update: 2018-07-30