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《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:

2018年01期

页码:

48-53

栏目:

基础研究

出版日期:

2018-01-25

文章信息/Info

Title:

The protective effect of 1-O-acetylbritannilactone in hypoxia injury of myocardial cells

作者:

酉鹏华; 饶堃睿; 林静; 陈海潮; 王军伟; 何晓敏

710068 西安,陕西省人民医院心血管内科(酉鹏华,林静,陈海潮,王军伟);. 330006 南昌市第一医院心血管内科(饶堃睿); 710068 西安理工大学医院内科(何晓敏)

Author(s):

YOU Penghua¹;  RAO Kunrui²;  LIN Jing¹;  CHEN Haichao¹;  WANG Junwei¹;  HE Xiaomin³.

1. Department of Cardiology, Shaanxi Provincial People’s Hospital, Shaanxi 710068; 2. Department of Cardiology, The First Hospital of Nanchang, Jiangxi 330006; 3. The Hospital of Xi’an University of Technology, Shaanxi 710068, China

关键词:

一氧乙酰旋覆花内酯;  心肌细胞;  缺氧;  核因子κB;  p65;  核因子κB抑制蛋白α

Keywords:

1-O-acetylbritannilactone;  Cardiac myocytes;  Hypoxia;  Nuclear factor κB;  p65;  IKBα

分类号:

-

DOI:

10.3969/j.issn.1673-534X.2018.01.013

文献标识码:

-

摘要:

目的:探讨一氧乙酰旋覆花内酯(1-O-acetylbritannilactone, ABL)在心肌细胞缺氧损伤中的作用及其机制。方法:体外培养H9C2心肌细胞,构建缺氧损伤模型,分为对照组、缺氧组、1 μmol/L ABL组和10 μmol/L ABL组。采用CCK-8法检测心肌细胞活力,采用RT-PCR检测白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)等炎症指标及还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶p67^phox亚基、NADPH

Abstract:

Objective:To explore the role and the underlying mechanism of 1-O-acetylbritannilactone(ABL)in hypoxic injury of myocardial cells.Methods:In vitro, H9C2 myocardial cells were exposed to hypoxia, and divided into control group, hypoxia group, 1 μmol/L ABL

参考文献/References

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备注/Memo

备注/Memo:

通信作者:何晓敏,Email:yph711@163.com

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更新日期/Last Update: 2018-04-01