索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]赵瑞芳,白春林.ω-3多不饱和脂肪酸在高血压中的作用机制及临床应用前景[J].国际心血管病杂志,2024,02:77-80.
点击复制

ω-3多不饱和脂肪酸在高血压中的作用机制及临床应用前景(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2024年02期
页码:
77-80
栏目:
综述
出版日期:
2024-03-25

文章信息/Info

Title:
-
作者:
赵瑞芳; 白春林
030001 太原，山西医科大学（赵瑞芳）；030001 太原，山西医科大学第二医院心内科（白春林）
Author(s):
-
关键词:
ω-3多不饱和脂肪酸; 高血压; 内皮细胞; 平滑肌细胞
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2024.02.004
文献标识码:
-
摘要:
高血压患病率逐年上升，为社会带来巨大的经济负担。研究发现，ω-3多不饱和脂肪酸可通过改善内皮细胞功能，增加一氧化氮生物利用度，激活血管平滑肌细胞的钾通道起到舒张血管、降低血压的作用。该文介绍ω-3多不饱和脂肪酸及其代谢产物降低血压的相关机制及临床应用前景。
Abstract:
-

参考文献/References

[1] Wang JG, Zhang W, Li Y, et al. Hypertension in China:epidemiology and treatment initiatives[J]. Nat Rev Cardiol, 2023, 20(8):531-545.
[2] Roth GA, Mensah GA, Fuster V. The global burden of cardiovascular diseases and risks: a compass for global action[J]. J Am Coll Cardiol, 2020, 76(25):2980-2981.
[3] Bercea CI, Cottrell GS, Tamagnini F, et al. Omega-3 polyunsaturated fatty acids and hypertension: a review of vasodilatory mechanisms of docosahexaenoic acid and eicosapentaenoic acid[J]. Br J Pharmacol, 2021, 178(4):860-877.
[4] Valenzuela PL, Carrera-Bastos P, Gálvez BG, et al. Lifestyle interventions for the prevention and treatment of hypertension[J]. Nat Rev Cardiol, 2021, 18(4):251-275.
[5] Singh RB, Nabavizadeh F, Fedacko J, et al. Dietary approaches to stop hypertension via indo-mediterranean foods, may be superior to DASH diet intervention[J]. Nutrients, 2022, 15(1):46.
[6] Valookaran AF, Bouchard J, Aloud BM, et al. Therapeutic potential of select dietary compounds in the management of hypertension and its cardiovascular complications[J]. Molecules, 2022, 27(21):7222.
[7] Jaca A, Dur?o S, Harbron J. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease[J]. S Afr Med J, 2020, 110(12):1158-1159.
[8] Barry AR, Dixon DL. Omega-3 fatty acids for the prevention of atherosclerotic cardiovascular disease[J]. Pharmacotherapy, 2021, 41(12):1056-1065.
[9] Khan SU, Lone AN, Khan MS, et al. Effect of omega-3 fatty acids on cardiovascular outcomes: a systematic review and meta-analysis[J]. EClinicalMedicine, 2021, 38:100997.
[10] Ni SM, Zhong ZH, Wei JT, et al. Association between dietary intake of polyunsaturated fatty acid and prevalence of hypertension in U.S. adults: a cross-sectional study using data from NHANES 2009–2016[J]. Hypertens Res, 2022, 45(3):516-526.
[11] Ma MH, Yang FK, Wang Z, et al. Association of plasma polyunsaturated fatty acids with arterial blood pressure: a Mendelian randomization study[J]. Medicine (Baltimore), 2021, 100(3):e24359.
[12] George M, Gupta A. Blood pressure-lowering effects of omega-3 polyunsaturated fatty acids: are these the missing link to explain the relationship between omega-3 polyunsaturated fatty acids and cardiovascular disease?[J]. J Am Heart Assoc, 2022, 11(11):e026258.
[13] Zhang X, Ritonja JA, Zhou N, et al. Omega-3 polyunsaturated fatty acids intake and blood pressure: a dose-response meta-analysis of randomized controlled trials[J]. J Am Heart Assoc, 2022, 11(11):e025071.
[14] Colussi G, Catena C, Novello M, et al. Impact of omega-3 polyunsaturated fatty acids on vascular function and blood pressure: relevance for cardiovascular outcomes[J]. Nutr Metab Cardiovasc Dis, 2017, 27(3):191-200.
[15] López D, Orta X, Casós K, et al. Upregulation of endothelial nitric oxide synthase in rat aorta after ingestion of fish oil-rich diet[J]. Am J Physiol Heart Circ Physiol, 2004, 287(2):H567-H572.
[16] Villalpando DM, Navarro R, Del Campo L, et al. Effect of dietary docosahexaenoic acid supplementation on the participation of vasodilator factors in aorta from orchidectomized rats[J]. PLoS One, 2015, 10(11):e0142039.
[17] Hoshi T, Wissuwa B, Tian YT, et al. Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca2＋-dependent K＋ channels[J]. Proc Natl Acad Sci U S A, 2013, 110(12):4816-4821.
[18] Tagetti A, Ericson U, Montagnana M, et al. Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: possible interaction with genes involved in 20-HETE and EETs metabolism[J]. Prostaglandins Other Lipid Mediat, 2015, 120:126-133.
[19] Limbu R, Cottrell GS, McNeish AJ. Characterisation of the vasodilation effects of DHA and EPA, n-3 PUFAs (fish oils), in rat aorta and mesenteric resistance arteries[J]. PLoS One, 2018, 13(2):e0192484.
[20] Nagaraj C, Tang B, Nagy BM, et al. Docosahexaenoic acid causes rapid pulmonary arterial relaxation via KCa channel-mediated hyperpolarisation in pulmonary hypertension[J]. Eur Respir J, 2016, 48(4):1127-1136.
[21] Fosmo AL, Skraastad ?B. The Kv7 channel and cardiovascular risk factors[J]. Front Cardiovasc Med, 2017, 4:75.
[22] Elinder F, Liin SI. Actions and mechanisms of polyunsaturated fatty acids on voltage-gated ion channels[J]. Front Physiol, 2017, 8:43.
[23] Barrese V, Stott JB, Figueiredo HB, et al. Angiotensin Ⅱpromotes KV7.4 channels degradation through reduced interaction with HSP90 (heat shock protein 90)[J]. Hypertension, 2018, 71(6):1091-1100.
[24] Frampton DJA, Choudhury K, Nikesj? J, et al. Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism[J]. Elife, 2022, 11:e77672.
[25] Li YW, Aziz Q, Anderson N, et al. Endothelial ATP-sensitive potassium channel protects against the development of hypertension and atherosclerosis[J]. Hypertension, 2020, 76(3):776-784.
[26] Dhar-Chowdhury P, Malester B, Rajacic P, et al. The regulation of ion channels and transporters by glycolytically derived ATP[J]. Cell Mol Life Sci, 2007, 64(23):3069-3083.
[27] Bercea C, Limbu R, Behnam K, et al. Omega-3 polyunsaturated fatty acid-induced vasodilation in mouse aorta and mesenteric arteries is not mediated by ATP-sensitive potassium channels[J]. Front Physiol, 2022, 13:1033216.
[28] Li JJ, Dou KF, Zhou ZG, et al. Role of omega-3 fatty acids in the prevention and treatment of cardiovascular diseases: a consensus statement from the Experts' Committee of National Society of Cardiometabolic Medicine[J]. Front Pharmacol, 2022, 13:1069992.
[29] Knapp HR, FitzGerald GA. The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension[J]. N Engl J Med, 1989, 320(16):1037-1043.
[30] Levinson PD, Iosiphidis AH, Saritelli AL, et al. Effects of n-3 fatty acids in essential hypertension[J]. Am J Hypertens, 1990, 3(10):754-760.
[31] Miller PE, Van Elswyk M, Alexander DD. Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: a meta-analysis of randomized controlled trials[J]. Am J Hypertens, 2014, 27(7):885-896.

备注/Memo

备注/Memo:
通信作者：白春林， E-mail：Bcl602@126.com
更新日期/Last Update: 2024-03-25