索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]杨硕,任明.白脂素在心血管疾病中的作用[J].国际心血管病杂志,2024,02:74-76.
点击复制

白脂素在心血管疾病中的作用(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2024年02期
页码:
74-76
栏目:
综述
出版日期:
2024-03-25

文章信息/Info

Title:
-
作者:
杨硕; 任明
810012 西宁，青海大学附属医院心血管内科
Author(s):
-
关键词:
白脂素; 心血管疾病; 炎性反应
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2024.02.003
文献标识码:
-
摘要:
白脂素（Asp）是新型糖原性脂肪因子，主要以心脏、肝脏为靶器官，具有促进炎症反应，介导炎症反应发生、氧化应激、细胞凋亡等作用。近年来发现，Asp与多种心血管疾病的发生、进展密切相关。该文介绍Asp与动脉粥样硬化、心肌梗死、高血压、扩张型心肌病的关系及相互作用机制，以期为临床诊疗提供新思路。
Abstract:
-

参考文献/References

[1] The Writing Committee of the Report on Cardiovascular Health and Diseases in China. Report on cardiovascular health and diseases in China 2021: an updated summary[J]. Biomed Environ Sci, 2022, 35(7):573-603.
[2] Lu YL, Yuan WW, Xiong XW, et al. Asprosin aggravates vascular endothelial dysfunction via disturbing mitochondrial dynamics in obesity models[J]. Obesity (Silver Spring), 2023, 31(3):732-743.
[3] Huang QQ, Chen S, Xiong XW, et al. Asprosin exacerbates endothelium inflammation induced by hyperlipidemia through activating IKKβ-NF-κBp65 pathway[J]. Inflammation, 2023, 46(2):623-638.
[4] Zou J, Xu C, Zhao ZW, et al. Asprosin inhibits macrophage lipid accumulation and reduces atherosclerotic burden by up-regulating ABCA1 and ABCG1 expression via the p38/Elk-1 pathway[J]. J Transl Med, 2022, 20(1):337.
[5] Romere C, Duerrschmid C, Bournat J, et al. Asprosin, a fasting-induced glucogenic protein hormone[J]. Cell, 2016, 165(3):566-579.
[6] Ugur K, Aydin S. Saliva and blood asprosin hormone concentration associated with obesity[J]. Int J Endocrinol, 2019, 2019:2521096.
[7] Hoffmann JG, Xie W, Chopra AR. Energy regulation mechanism and therapeutic potential of asprosin[J]. Diabetes, 2020, 69(4):559-566.
[8] Donma MM, Donma O. Asprosin: possible target in connection with ghrelin and cytokine network expression in the post-burn treatment[J]. Med Hypotheses, 2018, 118:163-168.
[9] 陈莎, 汪雄, 邱琛茗, 等. Spartin和白脂素在糖尿病心脏微血管内皮损伤中的作用及其机制探讨[J]. 四川大学学报(医学版), 2019, 50(6):827-834.
[10] Lee T, Yun SB, Jeong JH, et al. Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation[J]. Mol Cell Endocrinol, 2019, 486:96-104.
[11] Jung TW, Kim HC, Kim HU, et al. Asprosin attenuates insulin signaling pathway through PKCδ-activated ER stress and inflammation in skeletal muscle[J]. J Cell Physiol, 2019, 234(11):20888-20899.
[12] Atkin M, Laight D, Cummings MH. The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. A pilot double blind randomized placebo controlled trial[J]. J Diabetes Complications, 2016, 30(4):723-727.
[13] 乔莞宁, 陈虹印, 张扬. 氧化应激与动脉粥样硬化[J]. 中国动脉硬化杂志, 2023, 31(4):312-321.
[14] Zhang ZB, Tan YZ, Zhu LW, et al. Asprosin improves the survival of mesenchymal stromal cells in myocardial infarction by inhibiting apoptosis via the activated ERK1/2-SOD2 pathway[J].Life Sci, 2019, 231:116554.
[15] He YM, Shen L, Ge JB. Fallacies and possible remedies of the SYNTAX score[J]. J Interv Cardiol, 2020, 2020:8822308.
[16] Acara AC, Bolatkale M, K?z?lo?lu ?, et al. A novel biochemical marker for predicting the severity of ACS with unstable angina pectoris: asprosin[J]. Am J Emerg Med, 2018, 36(8):1504-1505.
[17] 刘舒恒. 间充质干细胞移植治疗心肌梗死的研究进展[J]. 中国临床新医学, 2022, 15(12):1188-1192.
[18] 王康, 殷洁, 张学丽, 等. 下丘脑室旁核内Toll样受体4轴对心肌梗死大鼠交感神经激活的影响[J]. 中华老年心脑血管病杂志,2022, 24(7):755-759.
[19] Wang R, Lin P, Sun HB, et al. Increased serum asprosin is correlated with diabetic nephropathy[J]. Diabetol Metab Syndr, 2021, 13(1):51.
[20] Wang XL, Wang JX, Chen JL, et al. Asprosin in the paraventricular nucleus induces sympathetic activation and pressor responses via cAMP-dependent ROS production[J]. Int J Mol Sci, 2022, 23(20):12595.
[21] Patel KP, Mayhan WG, Bidasee KR, et al. Enhanced angiotensinⅡ-mediated central sympathoexcitation in streptozotocin-induced diabetes: role of superoxide anion[J]. Am J Physiol Regul Integr Comp Physiol, 2011, 300(2):R311-R320.
[22] Wen MS, Wang CY, Yeh JK, et al. The role of Asprosin in patients with dilated cardiomyopathy[J]. BMC Cardiovasc Disord, 2020, 20(1):402.

备注/Memo

备注/Memo:
基金项目：青海省心血管疾病临床医学研究中心项目（2019-SF-L2）
通信作者：任明， E-mail：1104234597@qq.com
更新日期/Last Update: 2024-03-25