|本期目录/Table of Contents|

[1]黄舒影,陈骁楠,张俊峰,等.射血分数保留的心力衰竭小鼠端粒缩短的研究[J].国际心血管病杂志,2024,04:231-236.
　HUANG Shuying,CHEN Xiaonan,ZHANG Junfeng,et al.Effect of telomere attrition in mice of heart failure with preserved ejection fraction[J].International Journal of Cardiovascular Disease,2024,04:231-236.
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射血分数保留的心力衰竭小鼠端粒缩短的研究(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2024年04期
页码:
231-236
栏目:
基础研究
出版日期:
2024-07-31

文章信息/Info

Title:
Effect of telomere attrition in mice of heart failure with preserved ejection fraction?
作者:
黄舒影; 陈骁楠; 张俊峰; 张绘莉
作者单位：200011 上海交通大学医学院附属第九人民医院心内科
Author(s):
HUANG Shuying;  CHEN Xiaonan;  ZHANG Junfeng;  ZHANG Huili
Department of Cardiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai? 200011, China
关键词:
射血分数保留的心力衰竭; 端粒缩短; 基因敲除
Keywords:
Heart failure with preserved ejection fraction;  Telomere attrition;  Gene knock-out
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2024.04.011
文献标识码:
-
摘要:
目的：探讨端粒缩短与射血分数保留的心力衰竭（HFpEF）间的关系。方法：野生型C57BL/6J小鼠、第二代端粒酶敲除（mTRG2）和第三代mTRKO（mTRG3）小鼠简单随机抽样法分为对照组和HFpEF组，每组各8只。对照组给予标准饲料和饮水，HFpEF组给予60%高脂饲料和含0.5g/LN-硝基-L-精氨酸甲酯（L-NAME）的饮水，造模16周。造模开始后每2周检测小鼠左室射血分数（LVEF）、二尖瓣口舒张早期和晚期血流速度峰值的比值（E/A）、舒张早期二尖瓣口血流速度峰值和二尖瓣环运动速度峰值的比值（
Abstract:
Objective: To explore the relationship between telomere attrition and heart failure with preserved ejection fraction (HFpEF).? Methods: Wild-type C57BL/6J mice, second-generation mTRKO mice(mTRG2) and third-generation mTRKO mice(mTRG3) were divided into c

参考文献/References

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备注/Memo

备注/Memo:
基金项目：上海市自然科学基金（21ZR1438000）
通信作者：张绘莉， E-mail：huilizhang815@163.com
更新日期/Last Update: 2024-07-31