索引超出了数组界限。 文章摘要
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[1]卢俊权,农育新,魏学标,等.瓣膜内皮损伤致钙化性主动脉瓣疾病的分子机制[J].国际心血管病杂志,2024,04:212-215.
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瓣膜内皮损伤致钙化性主动脉瓣疾病的分子机制(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2024年04期
页码:
212-215
栏目:
综述
出版日期:
2024-07-31

文章信息/Info

Title:
-
作者:
卢俊权; 农育新; 魏学标; 余丹青
作者单位：510080 广州，广东省医学科学院广东省心血管病研究所 广东省人民医院心血管内科广东省冠心病防治研究重点实验室（卢俊权，农育新，余丹青）；510080 广州，广东省人民医院老年重症医学科 广东省老年医学研究所（魏学标）
Author(s):
-
关键词:
钙化性主动脉瓣疾病; 瓣膜内皮细胞; 瓣膜间质细胞; 钙化
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2024.04.006
文献标识码:
-
摘要:
钙化性主动脉瓣疾病（CAVD）是近年来常见的心血管疾病之一，其具体的发病机制尚不明确。瓣膜内皮细胞（VEC）是维持主动脉瓣稳态的屏障，机械力学因素、一氧化氮代谢障碍、氧化应激、脂质沉积和炎症均可引起VEC损伤，导致主动脉瓣钙化。此外，VEC还可以通过一氧化氮或内皮间充质转化来调节瓣膜间质细胞，影响主动脉瓣钙化的过程。该文总结了近年来VEC对CAVD的影响调控机制，为CAVD的治疗提供参考。
Abstract:
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备注/Memo

备注/Memo:
基金项目：广东省冠心病防治研究重点实验室项目（Y0120220151）；国家自然科学基金（82002014）；广东省自然科学基金（2021A1515010107）；广东省医学科研基金（A2019409）；广州市科技计划项目（201704020124）
通信作者：余丹青， E-mail：yudanqing@gdph.org.cn
更新日期/Last Update: 2024-07-31