索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]吕桐巍,侯攀,李攀,等.外泌体在动脉粥样硬化中的作用[J].国际心血管病杂志,2024,03:148-152.
点击复制

外泌体在动脉粥样硬化中的作用 (PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2024年03期
页码:
148-152
栏目:
综述
出版日期:
2024-05-20

文章信息/Info

Title:
-
作者:
吕桐巍; 侯攀; 李攀; 郭志福
200433 上海，中国人民解放军海军军医大学第一附属 医院心内科（吕桐巍，李攀，郭志福）；430070 武汉，中国人民解 放军中部战区总医院心内科（侯攀）
Author(s):
-
关键词:
动脉粥样硬化; 外泌体; 心血管疾病
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2024.03.006
文献标识码:
-
摘要:
外泌体（EXO）是微小的双层脂质囊泡，可由人体内多种细胞分泌，其中富含 多种分子，可对人体的多种生理功能进行调控或作为细胞间信号传递的一环。动脉粥样硬化 （AS）是心脑血管疾病的基本病理基础，目前已经对我国居民的健康产生了严重威胁。该文 介绍EXO 的特性，及其在AS 的发生机制、诊断与治疗方面的研究进展。
Abstract:
-

参考文献/References

[1] Bellin G, Gardin C, Ferroni L, et al. Exosome in cardiovascular diseases: a complex world full of hope[J]. Cells, 2019, 8(2):166.
[2] Mathieu M, Martin-Jaular L, Lavieu G, et al. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication[J]. Nat Cell Biol, 2019, 21(1):9- 17.
[3] Abels ER, Breakefield XO. Introduction to extracellular vesicles: biogenesis, RNA cargo selection, content, release, and uptake[J]. Cell Mol Neurobiol, 2016, 36(3):301-312.
[4] Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes[J]. Science, 2020, 367(6478):eaau6977.
[5] Wang C, Li ZL, Liu YN, et al. Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets[J]. Theranostics, 2021, 11(8):3996-4010.
[6] Wei YY, Nazari-Jahantigh M, Chan L, et al. The microRNA-342- 5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis[J]. Circulation, 2013, 127(15):1609-1619.
[7] Zhao Y, Li Y, Luo PY, et al. XBP1 splicing triggers miR- 150 transfer from smooth muscle cells to endothelial cells via extracellular vesicles[J]. Sci Rep, 2016, 6:28627.
[8] Yue YJ, Wang CL, Benedict C, et al. Interleukin-10 deficiency alters endothelial progenitor cell-derived exosome reparative effect on myocardial repair via integrin-linked kinase enrichment[J]. Circ Res, 2020, 126(3):315-329.
[9] Kapustin AN, Chatrou MLL, Drozdov I, et al. Vascular smooth muscle cell calcification is mediated by regulated exosome secretion[J]. Circ Res, 2015, 116(8):1312-1323.
[10] Koide T, Mandai S, Kitaoka R, et al. Circulating extracellular vesicle-propagated microRNA signature as a vascular calcification factor in chronic kidney disease[J]. Circ Res, 2023, 132(4):415-431.
[11] Wang C, Liu C, Shi JX, et al. Nicotine exacerbates endothelial dysfunction and drives atherosclerosis via extracellular vesiclemiRNA[ J]. Cardiovasc Res, 2023, 119(3):729-742.
[12] Bouchareychas L, Duong P, Covarrubias S, et al. Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via MicroRNA cargo[J]. Cell Rep, 2020, 32(2):107881.
[13] Gunassekaran GR, Poongkavithai Vadevoo SM, Baek MC, et al. M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages[J]. Biomaterials, 2021, 278:121137.
[14] Wu GH, Zhang JF, Zhao QR, et al. Molecularly engineered macrophage-derived exosomes with inflammation tropism and intrinsic heme biosynthesis for atherosclerosis treatment[J]. Angew Chem Int Ed Engl, 2020, 59(10):4068-4074.
[15] He ZW, Wang J, Zhu CH, et al. Exosome-derived FGD5- AS1 promotes tumor-associated macrophage M2 polarizationmediated pancreatic cancer cell proliferation and metastasis[J]. Cancer Lett, 2022, 548:215751.
[16] Wang Z, Zhang CJ, Meng JQ, et al. A targeted exosome therapeutic confers both CfDNA scavenging and macrophage polarization for ameliorating rheumatoid arthritis[J]. Adv Mater, 2023, 35(48):e2302503.
[17] Zhu JM, Liu B, Wang ZY, et al. Exosomes from nicotinestimulated macrophages accelerate atherosclerosis through miR- 21-3p/PTEN-mediated VSMC migration and proliferation[J]. Theranostics, 2019, 9(23):6901-6919.
[18] Hsu JJ, Lim J, Tintut Y, et al. Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification[J]. Heart, 2016, 102(21):1710-1715.
[19] Chiva-Blanch G, Suades R, Crespo J, et al. CD3+/CD45+ and SMA-α+ circulating microparticles are increased in individuals at high cardiovascular risk who will develop a major cardiovascular event[J]. Int J Cardiol, 2016, 208:147-149.
[20] Zhao L, Wang H, Fu J, et al. Microfluidic-based exosome isolation and highly sensitive aptamer exosome membrane protein detection for lung cancer diagnosis[J]. Biosens Bioelectron, 2022, 214:114487.
[21] Wang GK, Zhu JQ, Zhang JT, et al. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans[J]. Eur Heart J, 2010, 31(6):659-666.
[22] Aurora AB, Mahmoud AI, Luo X, et al. MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2＋ overload and cell death[J]. J Clin Invest, 2012, 122(4):1222- 1232.
[23] Sindi HA, Russomanno G, Satta S, et al. Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension[J]. Nat Commun, 2020, 11(1):1185.
[24] Hergenreider E, Heydt S, Tréguer K, et al. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs[J]. Nat Cell Biol, 2012, 14(3):249-256.
[25] Xu M, Feng T, Liu BW, et al. Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies[J]. Theranostics, 2021, 11(18):8926-8944.
[26] Fernandez-Trillo F, Grover LM, Stephenson-Brown A, et al. Vesicles in nature and the laboratory: elucidation of their biological properties and synthesis of increasingly complex synthetic vesicles[J]. Angew Chem Int Ed Engl, 2017, 56(12):3142-3160.
[27] Liang GF, Zhu YL, Ali DJ, et al. Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer[J]. J Nanobiotechnology, 2020, 18(1):10.
[28] Yan CQ, Chen J, Wang C, et al. Milk exosomes-mediated miR- 31-5p delivery accelerates diabetic wound healing through promoting angiogenesis[J]. Drug Deliv, 2022, 29(1):214-228.
[29] Fitzner D, Schnaars M, Van Rossum D, et al. Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis[J]. J Cell Sci, 2011, 124(Pt 3):447-458.
[30] Mondal J, Pillarisetti S, Junnuthula V, et al. Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications[J]. J Control Release, 2023, 353:1127- 1149.
[31] Liu DA, Tao K, Wu B, et al. A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion[J]. Nat Commun, 2023, 14(1):6883.
[32] Wu B, Liu DA, Guan L, et al. Stiff matrix induces exosome secretion to promote tumour growth[J]. Nat Cell Biol, 2023, 25(3):415-424.
[33] Mi BB, Chen L, Xiong Y, et al. Osteoblast/osteoclast and immune cocktail therapy of an exosome/drug delivery multifunctional hydrogel accelerates fracture repair[J]. ACS Nano, 2022, 16(1):771-782.

备注/Memo

备注/Memo:
通信作者：郭志福， E-mail：guozhifu@126.com
更新日期/Last Update: 2024-05-20