索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]高璐,王祁,赵博,等.TRPV1和TRPA1通道在心血管疾病中的作用[J].国际心血管病杂志,2024,01:4-6,10.
点击复制

TRPV1和TRPA1通道在心血管疾病中的作用(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2024年01期
页码:
4-6,10
栏目:
综述
出版日期:
2024-01-22

文章信息/Info

Title:
-
作者:
高璐; 王祁; 赵博; 屈新亮; 王斌; 李敏仪; 卫培峰; 董泰玮; 高峰; 李敏
712046 西安，陕西中医药大学药学院
Author(s):
-
关键词:
瞬时受体电位通道; 瞬时受体电位香草酸亚型1 ; 瞬时受体电位锚蛋白1 ; 心 血管疾病
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2024.01.002
文献标识码:
-
摘要:
瞬时受体电位（TRP）通道为机体重要的非选择性阳离子通道，瞬时受体电位 香草酸亚型1（TRPV1）属于TRP 通道香草酸受体亚型家族成员，瞬时受体电位锚蛋白1 （TRPA1）属于TRP 通道超家族成员。TRPV1 和TRPA1 通道可调节血管内皮细胞和心肌 细胞功能，其异常表达及功能改变与心血管疾病的发生发展关系密切。TRPV1 通道参与心 肌梗死后心脏保护和血压调节。TRPA1 通道参与调节血流量、血管生成和心肌细胞凋亡。 TRPV1 和TRPA1 通道有望成为心血管疾病的治疗靶点。
Abstract:
-

参考文献/References

[1] Ndejjo R, Hassen HY, Wanyenze RK, et al. Community-based interventions for cardiovascular disease prevention in low-and middle-income countries: a systematic review[J]. Public Health Rev, 2021, 42:1604018.
[2] 张萌, 高山, 饶宏宇, 等. 血浆环状RNA在心血管疾病中的研究 进展[J]. 中国现代医生, 2022, 60(20):112-115.
[3] Moraes RDA, Webb RC, Silva DF. Vascular dysfunction in diabetes and obesity: focus on TRP channels[J]. Front Physiol, 2021, 12:645109.
[4] Inoue R, Kurahara LH, Hiraishi K. TRP channels in cardiac and intestinal fibrosis[J]. Semin Cell Dev Biol, 2019, 94:40-49.
[5] Bishnoi M, Khare P, Brown L, et al. Transient receptor potential (TRP) channels: a metabolic TR(i)P to obesity prevention and therapy[J]. Obes Rev, 2018, 19(9):1269-1292.
[6] Kuppusamy M, Ottolini M, Sonkusare SK. Role of TRP ion channels in cerebral circulation and neurovascular communication[J]. Neurosci Lett, 2021, 765:136258.
[7] Negri S, Sanford M, Shi H, et al. The role of endothelial TRP channels in age-related vascular cognitive impairment and dementia[J]. Front Aging Neurosci, 2023, 15:1149820.
[8] 孙韬. 膳食辣椒对糖尿病大鼠神经损害及心肌缺血再灌注损 伤的影响及其机制研究[D]. 太原:山西医科大学, 2016.
[9] Yue WWS, Yuan L, Braz JM, et al. TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons[J]. Elife, 2022, 11:e80139.
[10] Hajna Z, Csek? K, Kemény ?, et al. Complex regulatory role of the TRPA1 receptor in acute and chronic airway inflammation mouse models[J]. Int J Mol Sci, 2020, 21(11):4109.
[11] Fernandes ES, Russell FA, Alawi KM, et al. Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner[J]. Arthritis Res Ther, 2016, 18:7.
[12] Wang Z, Ye D, Ye J, et al. The TRPA1 channel in the cardiovascular system: promising features and challenges[J]. Front Pharmacol, 2019, 10:1253.
[13] Ma J, Chen L, Fan J, et al. Dual-targeting rutaecarpine-NO donor hybrids as novel anti-hypertensive agents by promoting release of CGRP[J]. Eur J Med Chem, 2019, 168:146-153.
[14] Zhang C, Ye L, Zhang Q, et al. The role of TRPV1 channels in atherosclerosis[J]. Channels (Austin), 2020, 14(1):141-150.
[15] 王秋月. 辣椒素减轻糖尿病大鼠心肌纤维化和血管内皮功能 障碍的机制研究[D]. 合肥:安徽医科大学, 2022.
[16] Wang Y, Cui L, Xu H, et al. TRPV1 agonism inhibits endothelial cell inflammation via activation of eNOS/NO pathway[J]. Atherosclerosis, 2017, 260:13-19.
[17] Munjuluri S, Wilkerson DA, Sooch G, et al. Capsaicin and TRPV1 channels in the cardiovascular system: the role of inflammation[J]. Cells, 2021, 11(1):18.
[18] Zhong B, Rubinstein J, Ma S, et al. Genetic ablation of TRPV1 exacerbates pressure overload-induced cardiac hypertrophy[J]. Biomed Pharmacother, 2018, 99:261-270.
[19] Chen J, Hamers AJP, Finsterbusch M, et al. Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis[J]. FASEB J, 2018, 32(7):3816-3831.
[20] Li R, Liu R, Yan F, et al. Inhibition of TRPA1 promotes cardiac repair in mice after myocardial infarction[J]. J Cardiovasc Pharmacol, 2020, 75(3):240-249.
[21] Alvarado MG, Thakore P, Earley S. Transient receptor potential channel ankyrin 1: a unique regulator of vascular function[J]. Cells, 2021, 10(5):1167.
[22] Thapa D, Valente JS, Barrett B, et al. Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing[J]. Elife, 2021, 10:e70153.
[23] Peixoto-Neves D, Soni H, Adebiyi A. CGRPergic nerve TRPA1 channels contribute to epigallocatechin gallate-induced neurogenic vasodilation[J]. ACS Chem Neurosci, 2019, 10(1):216-220.
[24] Pinkney AMH, Lemmey HAL, Dora KA, et al. Vasorelaxation to the nitroxyl donor isopropylamine NONOate in resistance arteries does not require perivascular calcitonin gene-related peptide[J]. Hypertension, 2017:HYPERTENSIONAHA.117.09737. [Epub ahead of print].
[25] Szabados T, G?m?ri K, Pálv?lgyi L, et al. Capsaicin-sensitive sensory nerves and the TRPV1 ion channel in cardiac physiology and pathologies[J]. Int J Mol Sci, 2020, 21(12):4472.
[26] Zhong B, Ma S, Wang DH. Protease-activated receptor 2 protects against myocardial ischemia-reperfusion injury through the lipoxygenase pathway and TRPV1 channels[J]. Exp Ther Med, 2019, 18(5):3636-3642.
[27] Xu S, Xu Y, Cheng X, et al. Inhibition of DRG-TRPV1 upregulation in myocardial ischemia contributes to exogenous cardioprotection[J]. J Mol Cell Cardiol, 2020, 138:175-184.
[28] Wang Q, Zhang C, Yang C, et al. Capsaicin alleviates vascular endothelial dysfunction and cardiomyopathy via TRPV1/eNOS pathway in diabetic rats[J]. Oxid Med Cell Longev, 2022, 2022:6482363.
[29] Castrejón-Téllez V, del Valle-Mondragón L, Pérez-Torres I, et al. TRPV1 contributes to modulate the nitric oxide pathway and oxidative stress in the isolated and perfused rat heart during ischemia and reperfusion[J]. Molecules, 2022, 27(3):1031.
[30] Andrei SR, Ghosh M, Sinharoy P, et al. TRPA1 ion channel stimulation enhances cardiomyocyte contractile function via a CaMKⅡ-dependent pathway[J]. Channels (Austin), 2017, 11(6):587-603.
[31] Andrei SR, Ghosh M, Sinharoy P, et al. Stimulation of TRPA1 attenuates ischemia-induced cardiomyocyte cell death through an eNOS-mediated mechanism[J]. Channels (Austin), 2019, 13(1):192-206.
[32] Wang Z, Xu Y, Wang M, et al. TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice[J]. EBioMedicine, 2018, 36:54-62.
[33] Li W, Zhang Z, Li X, et al. CGRP derived from cardiac fibroblasts is an endogenous suppressor of cardiac fibrosis[J]. Cardiovasc Res, 2020, 116(7):1335-1348.
[34] Wang D, Hou J, Yang Y, et al. Cinnamaldehyde ameliorates high-glucose-induced oxidative stress and cardiomyocyte injury through transient receptor potential ankyrin 1[J]. J Cardiovasc Pharmacol, 2019, 74(1):30-37.
[35] Hoebart C, Rojas-Galvan NS, Ciotu CI, et al. No functional TRPA1 in cardiomyocytes[J]. Acta Physiol (Oxf), 2021, 232(4):e13659.

备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81303243）；陕西中医药大学创新 团队项目（2019-QN02）；陕西省科技厅项目（2022SF-270） 通信作者：李敏，E-mail：413159921@qq.com
更新日期/Last Update: 2024-01-22