索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]丁桃,胥玉林,涂梦婷,等.小檗碱治疗动脉粥样硬化的研究进展[J].国际心血管病杂志,2023,04:205-208，212.
点击复制

小檗碱治疗动脉粥样硬化的研究进展(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2023年04期
页码:
205-208，212
栏目:
综述
出版日期:
2023-07-30

文章信息/Info

Title:
-
作者:
丁桃; 胥玉林; 涂梦婷; 郑翠翠; 赵瞳; 鲁启文; 罗桑; 万强
330004 南昌，江西中医药大学临床医学院（丁桃，胥玉林，涂梦婷，郑翠翠，赵瞳，鲁启文，罗桑）；330006 南昌，江西中医药大学附属医院心血管科（万强）通信作者：万强， E-mail：wanqiang109559140@163.com
Author(s):
-
关键词:
小檗碱; 动脉粥样硬化; 作用机制; 研究进展
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2023.04.004
文献标识码:
-
摘要:
小檗碱是一种异喹啉类生物碱，研究表明小檗碱具有抗动脉粥样硬化的作用。小檗碱可通过调脂、抗炎、抗氧化应激、改善血管内皮功能障碍、调控血管平滑肌细胞增殖与迁移、抗血栓等机制抗动脉粥样硬化。该文介绍小檗碱治疗动脉粥样硬化的研究进展。
Abstract:
-

参考文献/References

[1] 中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2021概要[J]. 中国循环杂志, 2022, 37(6):553-578.
[2]Rafieian-Kopaei M, Setorki M, Doudi M, et al. Atherosclerosis: process, indicators, risk factors and new hopes[J]. Int J Prev Med, 2014, 5(8):927-946.
[3]Stefanadis C, Antoniou CK, Tsiachris D, et al. Coronary atherosclerotic vulnerable plaque: current perspectives[J]. J Am Heart Assoc, 2017, 6(3):e005543.
[4]Ruscica M, Ferri N, Banach M, et al. Side effects of statins:from pathophysiology and epidemiology to diagnostic and therapeutic implications[J]. Cardiovasc Res, 2023, 118(17):3288-3304.
[5] 周瑞, 项昌培, 张晶晶, 等. 黄连化学成分及小檗碱药理作用研究进展[J]. 中国中药杂志, 2020, 45(19):4561-4573.
[6]Feng M, Zou ZY, Zhou X, et al. Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE-/- mice[J]. Int Immunopharmacol,2017, 43:195-202.
[7]Bennett BJ, de Aguiar Vallim TQ, Wang ZN, et al. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation[J]. Cell Metab, 2013, 17(1):49-60.
[8] 史亚非. 黄连素对ApoE受体基因敲除小鼠肠道菌群结构及动脉粥样硬化的影响[D]. 南京:南京医科大学, 2019.
[9]Petroglou D, Kanellos I, Savopoulos C, et al. The LDL-receptor and its molecular properties:from theory to novel biochemical and pharmacological approaches in reducing LDL-cholesterol[J]. Curr Med Chem, 2020, 27(2):317-333.
[10] Wang Q, Liu SD, Zhai AH, et al. AMPK-mediated regulation of lipid metabolism by phosphorylation[J]. Biol Pharm Bull, 2018, 41(7):985-993.
[11] 左璇, 罗金雀, 姜新海, 等. 小檗碱对ApoE-/-小鼠动脉粥样硬化的影响及机制研究[J]. 药学学报, 2019, 54(1):104-110.
[12] León-Martínez JM, Martínez-Abundis E, González-Ortiz M, et al. Effect of berberine plus bezafibrate administration on the lipid profile of patients with mixed dyslipidemia:a pilot clinical trial[J]. J Med Food, 2021, 24(2):111-115.
[13] Boya P, Codogno P, Rodriguez-Muela N. Autophagy in stem cells: repair, remodelling and metabolic reprogramming[J]. Development, 2018, 145(4):dev146506.
[14] 密泗宇. 黄连素对动脉粥样硬化中巨噬细胞自噬功能调控机制的研究[D]. 宁波:宁波大学, 2018.
[15] Zhai CG, Cheng J, Mujahid H, et al. Selective inhibition of PI3K/Akt/mTOR signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaque[J]. PLoS One, 2014, 9(3):e90563.
[16] Song T, Chen WD. Berberine inhibited carotid atherosclerosis through PI3K/AKTmTOR signaling pathway[J]. Bioengineered, 2021, 12(1):8135-8146.
[17] Libby P. Inflammation during the life cycle of the atherosclerotic plaque[J]. Cardiovasc Res, 2021, 117(13):2525-2536.
[18] Rui R, Yang HL, Liu YK, et al. Effects of berberine on atherosclerosis[J]. Front Pharmacol, 2021, 12:764175.
[19] Zhu QW, Li, YG. Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling[J]. Exp Ther Med, 2016, 11(3):978-984.
[20] Zhang H, Shan Y, Wu Y, et al. Berberine suppresses LPS-induced inflammation through modulating Sirt1/NF-κB signaling pathway in RAW264.7 cells[J]. Int Immunopharmacol, 2017, 52:93-100.
[21] Pei CZ, Zhang Y, Wang P, et al. Berberine alleviates oxidized low-density lipoprotein-induced macrophage activation by downregulating galectin-3 via the NF-κB and AMPK signaling pathways[J]. Phytother Res, 2019, 33(2):294-308.
[22] Chun Y, Kim J. AMPK-mTOR signaling and cellular adaptations in hypoxia[J]. Int J Mol Sci, 2021, 22(18):9765.
[23] 刘琴, 杨黎星, 石婧, 等. 小檗碱激活巨噬细胞自噬并改善动脉粥样硬化斑块脆弱性[J]. 基础医学与临床, 2020, 40(5):668-677.
[24] 高伟东, 杨龙龙, 尹清臣. 氧化应激反应在边缘供肝肝移植缺血-再灌注损伤中的作用研究进展[J]. 器官移植, 2022, 13(1):126-131.
[25] 宋必卫, 杨轶安. 香附挥发油诱导A549细胞凋亡作用[J]. 浙江工业大学学报, 2019, 47(1):92-97.
[26] 柴美静, 李轩, 杨凡, 等. 小檗碱对急性缺血性脑卒中患者氧化应激及神经功能的影响[J]. 上海中医药大学学报, 2017, 31(3):26-29.
[27] Li HJ, He CY, Wang JY, et al. Berberine activates peroxisome proliferator-activated receptor gamma to increase atherosclerotic plaque stability in Apoe-/- mice with hyperhomocysteinemia[J]. J Diabetes Investig, 2016, 7(6):824-832.
[28] 张城林, 何蕾, 王力, 等. 内皮功能障碍的发生机制[J]. 中国科学:生命科学, 2022, 52(5):691-698.
[29] Tan WX, Wang Y, Wang KY, et al. Improvement of endothelial dysfunction of berberine in atherosclerotic mice and mechanism exploring through TMT-based proteomics[J]. Oxid Med Cell Longev, 2020, 2020:8683404.
[30] 马春艳, 徐瑞霞, 姚雨宏, 等. 小檗碱抑制氧化型低密度脂蛋白诱导的人脐静脉内皮细胞增殖及其分子机制[J]. 中国动脉硬化杂志, 2018, 26(2):144-151.
[31] Chen L, Fan XD, Qu H, et al. Berberine protects against TNF-α-induced injury of human umbilical vein endothelial cells via the AMPK/NF-κB/YY1 signaling pathway[J]. Evid Based Complement Alternat Med, 2021, 2021:6518355.
[32] 张振, 郭刚. 不同剂量黄连素与他汀类药物联合治疗高血压合并动脉粥样硬化的临床疗效[J]. 心脑血管病防治, 2022, 22(2):46-49.
[33] Grootaert MOJ, Bennett MR. Vascular smooth muscle cells in atherosclerosis:time for a re-assessment[J]. Cardiovasc Res, 2021, 117(11):2326-2339.
[34] Wang LL, Deng L, Lin N, et al. Berberine inhibits proliferation and apoptosis of vascular smooth muscle cells induced by mechanical stretch via the PDI/ERS and MAPK pathways[J]. Life Sci, 2020, 259:118253.
[35] Qiu HM, Wu Y, Wang QH, et al. Effect of berberine on PPARα-NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin Ⅳ[J]. Pharm Biol, 2017, 55(1):227-232.
[36] Liu SJ, Yin CX, Ding MC, et al. Berberine suppresses in vitro migration of human aortic smooth muscle cells through the inhibitions of MMP-2/9, u-PA, AP-1, and NF-κB[J]. BMB Rep, 2014, 47(7):388-392.
[37] 张旭慧. 小檗碱对血管平滑肌细胞钙化的影响及其机制初探[D]. 石家庄:河北医科大学, 2018.
[38] Wang C, Cheng YY, Zhang YH, et al. Berberine and its main metabolite berberrubine inhibit platelet activation through suppressing the class I PI3Kβ/Rasa3/Rap1 pathway[J]. Front Pharmacol, 2021, 12:734603.
[39] 赵美萍. 盐酸小檗碱对急性脑梗死患者外周血大血小板比率的影响[D]. 大连:大连医科大学, 2012.[40] Wang C, Wu YB, Wang AP, et al. Evaluation of anticoagulant and antithrombotic activities of berberine:a focus on the ameliorative effect on blood hypercoagulation[J]. Int J Pharmacol, 2018, 14(8):1087-1098.

备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81660770）；江西省教育厅科学技术研究项目（GJJ190654）；江西省重点研发计划（20202BBGL73008）；江西省卫生健康委科技计划（202310664）；江西中医药大学校级研究生创新专项资金项目（JZYC22S29）
（收稿：2022-09-28 修回：2023-02-18）
更新日期/Last Update: 2023-08-01