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《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:

2022年05期

页码:

303-307

栏目:

基础研究

出版日期:

2022-10-01

文章信息/Info

Title:

Hydrogen sulfide alleviates myocardial fibrosis in diabetic rats via regulating autophagy

作者:

曾欧; 肖归; 陈海波; 张意平

423000 郴州市第一人民医院心内科

Author(s):

ZENG Ou;  XIAO Gui;  CHEN Haibo;  ZHANG Yiping

Department of Cardiovascular treated with Medicine, Chenzhou First People’s Hospital, Hunan 423000, China

关键词:

糖尿病; 硫化氢; 自噬; 心肌纤维化

Keywords:

Diabetes; Hydrogen sulfide; Autophagy;  Myocardial fibrosis

分类号:

-

DOI:

10.3969/j.issn.1673-6583.2022.05.013

文献标识码:

-

摘要:

目的：探讨气体信号分子硫化氢（H2S）是否通过调节细胞自噬改善糖尿病大鼠 心肌细胞纤维化。 方法：链脲佐菌素（STZ）腹腔注射建立糖尿病大鼠模型。60 只7 周龄 SD 雄性大鼠随机分成6 组（每组10 只），分别为对照组、糖尿病组（STZ 组）、STZ＋高浓 度H2S 组（100 mg/kg NaHS）、STZ＋中浓度H2S 组（60 mg/kg NaHS）、STZ＋低浓度H2S 组 （40 mg/kg NaHS）、STZ＋胱硫酸-γ- 裂合酶抑制剂炔丙基甘氨酸（PPG）组（30 mg/kg PPG）。

Abstract:

Objective：The aim of this study was to determine whether gas signaling molecule hydrogen sulfide could improve myocardial fibrosis in diabetic rats by regulating the activities of autophagy. Methods：Sixty 7-week-old male SD rats were randomly divided into

参考文献/References

[1] 潘大彬, 汪旻晖, 曹蘅. 糖尿病心肌病发病机制的研究进展 [J]. 中国临床药理学与治疗学, 2013, 18(7):831-836.
[2] Trachanas K, Sideris S, Aggeli C, et al. Diabetic cardiomyopathy: from pathophysiology to treatment[J]. Hellenic J Cardiol, 2014, 55(5):411-421.
[3] Kimura H. Hydrogen sulfide and polysulfides as signaling molecules[J]. Proc Jpn Acad Ser B Phys Biol Sci, 2015, 91(4):131-159.
[4] Wang YZ, Ngowi EE, Wang D, et al. The potential of hydrogen sulfide donors in treating cardiovascular diseases[J]. Int J Mol Sci, 2021, 22(4):2194.
[5] Kimura H. Production and physiological effects of Hydrogen sulfide[J]. Antioxid Redox Signal, 2014, 20(5):783-793.
[6] Zheng W, Liu C. The cystathionine γ-lyase/Hydrogen sulfide pathway mediates the trimetazidine-induced protection of H9c2 cells against hypoxia/reoxygenation-induced apoptosis and oxidative stress[J]. Anatol J Cardiol, 2019, 22(3):102-111.
[7] Zhou X, An G, Lu X. Hydrogen sulfide attenuates the development of diabetic cardiomyopathy[J]. Clin Sci (Lond), 2015, 128(5):325-335.
[8] Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030[J]. Diabetes Care, 2004, 27(5):1047-1053.
[9] Boudina S, Abel ED. Diabetic cardiomyopathy revisited[J]. Circulation, 2007, 115(25):3213-3223.
[10] Falc?o-Pires I, Leite-Moreira AF. Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment[J]. Heart Fail Rev, 2012, 17(3):325- 344.
[11] Rubler S, Dlugash J, Yuceoglu YZ, et al. New type of cardiomyopathy associated with diabetic glomerulosclerosis[J]. Am J Cardiol, 1972, 30(6):595-602.
[12] Fan D, Takawale A, Lee J, et al. Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease[J]. Fibrogenesis Tissue Repair, 2012, 5(1):15.
[13] Kong P, Christia P, Frangogiannis NG. The pathogenesis of cardiac fibrosis[J]. Cell Mol Life Sci, 2014, 71(4):549-574.
[14] 杨琼, 吴永全. 内质网应激与糖尿病心肌纤维化[J]. 心脏杂 志, 2014, 26(1):91-93.
[15] Kalachev AV, Yurchenko OV. Microautophagy in nutritive phagocytes of sea urchins[J]. Protoplasma, 2017, 254(1):609- 614.
[16] Lawrence J, Nho R. The Role of the Mammalian target of rapamycin (mTOR) in pulmonary fibrosis[J]. Int J Mol Sci, 2018, 19(3):778.
[17] Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms[J]. J Pathol, 2010, 221(1):3-12.
[18] Kirkin V, Mcewan DG, Novak I, et al. A role for ubiquitin in selective autophagy[J]. Mol Cell, 2009, 34(3):259-269.
[19] Kim I, Rodriguez-Enriquez S, Lemasters JJ. Selective degradation of mitochondria by mitophagy[J]. Arch Biochem Biophys, 2007, 462(2):245-253.

备注/Memo

备注/Memo:

基金项目：郴州市第一人民医院院内优秀青年科学基金（N2019-007）；郴州市科技局科学基金（zdyf201952）；湘南学院校级科学研究项目 （2018XJ69）
通信作者：张意平， E-mail：434840868@qq.com

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更新日期/Last Update: 2022-10-01