|本期目录/Table of Contents|

[1]智丽霞,王康,殷利茜,等.血凝集素样氧化型低密度脂蛋白受体-1在氧化型低密度脂蛋白诱导的巨噬细胞氧化应激中的作用[J].国际心血管病杂志,2022,05:293-298.
　ZHI Lixia,WANG Kang,YIN Lixi,et al.Effects of Lectin-like oxidized low-density lipoprotein receptor-1 on oxidative stress of macrophages induced by oxidized low-density lipoprotein[J].International Journal of Cardiovascular Disease,2022,05:293-298.
点击复制

血凝集素样氧化型低密度脂蛋白受体-1在氧化型低密度脂蛋白诱导的巨噬细胞氧化应激中的作用(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2022年05期
页码:
293-298
栏目:
基础研究
出版日期:
2022-10-01

文章信息/Info

Title:
Effects of Lectin-like oxidized low-density lipoprotein receptor-1 on oxidative stress of macrophages induced by oxidized low-density lipoprotein
作者:
智丽霞; 王康; 殷利茜; 马茴煌; 李姚娜; 杨慧宇
037000 太原，山西医科大学第二医院心血管内科
Author(s):
ZHI Lixia;  WANG Kang; YIN Lixi;  MA Huihuang;  LI Yaona;  YANG Huiyu
Department of Cardiovascular Medicine, Second Hospital of Shanxi Medical University, Taiyaun 037000, China
关键词:
血凝集素样氧化型低密度脂蛋白受体-1 ; 氧化型低密度脂蛋白; 巨噬细胞;  氧化应激
Keywords:
Lectin-like oxidized low-density lipoprotein receptor-1;  Oxidized lowdensity lipoprotein;  Macrophages;  Oxidative stress
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2022.05.011
文献标识码:
-
摘要:
目的：探讨血凝集素样氧化型低密度脂蛋白受体-1（LOX-1）在氧化型低密度 脂蛋白（ox-LDL）诱导的巨噬细胞氧化应激中的作用。 方法：将生长至对数增殖期的巨 噬细胞随机分成对照组、空质粒对照组（pCon 组）、ox-LDL 组、LOX-1- 小干扰RNA（siRNA） ＋ox-LDL 组，分别测定各组丙二醛（MDA）含量及超氧化物歧化酶（SOD）活性，荧光显 微镜及流式细胞仪检测各组巨噬细胞活性氧（ROS）水平，实时定量聚合酶链反应（PCR） 及Western blot 法检测各组还原型烟酰胺腺嘌呤二
Abstract:
Objective: To evaluate the role of Lectin-like oxidized low-density lipoprotein receptor-1 in oxidative stress of macrophages induced by oxidized low-density lipoprotein (ox-LDL). Methods: Macrophages growing to logarithmic proliferation stage were random

参考文献/References

[1] 郑旭, 张梦诃, 邓姣, 等. LOX-1在动脉粥样硬化中的作用研 究新进展[J]. 心脏杂志, 2018, 30(2):212-217.
[2] Poznyak AV, Grechko AV, Orekhova VA, et al. NADPH oxidases and their role in atherosclerosis[J]. Biomedicines, 2020, 8(7):206.
[3] 王竹, 高永翔. 动脉粥样硬化与巨噬细胞源性泡沫细胞的 相关研究进展[J]. 细胞与分子免疫学杂志, 2015, 31(6):853- 855.
[4] Matyas C, Haskó G, Liaudet L, et al. Interplay of cardiovascular mediators, oxidative stress and inflammation in liver disease and its complications[J]. Nat Rev Cardiol, 2021, 18(2):117-135.
[5] Golforoush P, Yellon DM, Davidson SM. Mouse models of atherosclerosis and their suitability for the study of myocardial infarction[J]. Basic Res Cardiol, 2020, 115(6):73.
[6] 陈修平, 赵海誉, 钟章锋, 等.“氧化型低密度脂蛋白-凝集素 样氧化型低密度脂蛋白受体1-活性氧”信号通路参与泡沫 细胞的形成(英文)[J]. 中国动脉硬化杂志, 2010, 18(7):577- 581.
[7] Libby P, Ganz P. Restenosis revisited—new targets, new therapies[J]. N Engl J Med, 1997, 337(6):418-419.
[8] Ding ZF, Wang XW, Schnackenberg L, et al. Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7g[J]. Int J Cardiol, 2013, 168(2):1378- 1385.
[9] He F, Liu Q, Jing M, et al. Toxic mechanism on phenanthreneinduced cytotoxicity, oxidative stress and activity changes of superoxide dismutase and catalase in earthworm (Eisenia foetida): a combined molecular and cellular study[J]. J Hazard Mater, 2021, 418:126302.
[10] 刘晓霞, 陈剑华, 贾金海, 等. 不同类型肺癌患者氧化应激 状态及其相关因素研究[J]. 实用心脑肺血管病杂志, 2020, 28(9):52-56.
[11] Mohideen K, Sudhakar U, Balakrishnan T, e t a l . Malondialdehyde, an oxidative stress marker in oral squamous cell carcinoma—a systematic review and meta-analysis[J]. Curr Issues Mol Biol, 2021, 43(2):1019-1035.
[12] 樊碧娆, 姚伟娟. 氧化型低密度脂蛋白受体在动脉粥样 硬化发病机制中的作用[J]. 中国病理生理杂志, 2020, 36(10):1897-1901.
[13] Brennan AM, Suh SW, Won SJ, et al. NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation[J]. Nat Neurosci, 2009, 12(7):857-863.
[14] Robbesyn F, Salvayre R, Negre-Salvayre A. Dual role of oxidized LDL on the NF-kappaB signaling pathway[J]. Free Radic Res, 2004, 38(6):541-551.
[15] Ma S, Bai Z, Wu H, et al. The DPP-4 inhibitor saxagliptin ameliorates ox-LDL-induced endothelial dysfunction by regulating AP-1 and NF-κB[J]. Eur J Pharmacol, 2019, 851:186-193.
[16] Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology[J]. Physiol Rev, 2007, 87(1):245-313.
[17] Xu S, Ogura S, Chen J, et al. LOX-1 in atherosclerosis: biological functions and pharmacological modifiers[J]. Cell Mol Life Sci, 2013, 70(16):2859-2872.

备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81700407）
通信作者：杨慧宇， E-mail：yanghuiyu2020@126.com
更新日期/Last Update: 2022-10-01