索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]游紫阳,郑丽婷,林万鹏,等.瞬时受体电位锚蛋白1通道在心血管疾病中的研究进展[J].国际心血管病杂志,2022,05:267-270.
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瞬时受体电位锚蛋白1通道在心血管疾病中的研究进展(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2022年05期
页码:
267-270
栏目:
综述
出版日期:
2022-10-01

文章信息/Info

Title:
-
作者:
游紫阳; 郑丽婷; 林万鹏; 邱小宇; 冯莉; 杨骄霞
157011 牡丹江医学院（游紫阳，郑丽婷，林万鹏， 邱小宇，冯莉）；157011 牡丹江医学院附属红旗医院心血管内科 （杨骄霞）
Author(s):
-
关键词:
瞬时受体电位通道; 瞬时受体电位锚蛋白1 通道; 心血管疾病
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2022.05.004
文献标识码:
-
摘要:
瞬时受体电位锚蛋白1 通道（TRPA1）是一种Ca2＋高渗透性通道，在心血管系 统中广泛表达，可被多种化学物质及内源性化合物激活，产生以Ca2＋内流为主的跨膜电压变 化，参与一系列心血管疾病的病理生理过程。该文主要介绍TRPA1 通道在调节心血管疾病 病理生理方面的潜在作用，包括在动脉粥样硬化、心力衰竭、心肌缺血再灌注损伤、心肌纤 维化及心肌肥厚、心律失常中的作用。
Abstract:
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参考文献/References

[1] Hofmann L, Wang H, Zheng W, et al. The S4-S5 linker— gearbox of TRP Channel gating[J]. Cell Calcium, 2017, 67(67):156-165.
[2] Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels[J]. Annu Rev Physiol, 2006, 68(4):619-647.
[3] Ma J, Yang L, Ma Y, et al. Targeting transient receptor potential channels in cardiometabolic diseases and myocardial ischemia reperfusion injury[J]. Curr Drug Targets, 2017, 18(15):1733-1745.
[4] 贾振华, 黄渊, 唐景峰, 等. TRP通道超家族的基本特征及其 与疾病的关系[J]. 生命科学, 2020, 32(9):903-914.
[5] Dietrich A, Steinritz D, Gudermann T. Transient receptor potential (TRP) channels as molecular targets in lung toxicology and associated diseases[J]. Cell Calcium, 2017, 67(4):123-137.
[6] Winter Z, Gruschwitz P, Eger S, et al. Cold temperature encoding by cutaneous TRPA1 and TRPM8-carrying fibers in the mouse[J]. Front Mol Neurosci, 2017, 10(4):209.
[7] Yin S, Wang P, Xing R, et al. Transient receptor potential ankyrin 1 (TRPA1) mediates lipopolysaccharide (LPS)- induced inflammatory responses in primary human osteoarthritic fibroblast-like synoviocytes[J]. Inflammation, 2018, 41(2):700-709.
[8] Zhao JF, Shyue SK, Kou YR, et al. Transient receptor potential ankyrin 1 Channel involved in atherosclerosis and macrophage-foam cell formation[J]. Int J Biol Sci, 2016, 12(7):812-823.
[9] Lin YW, Liu PS, Adhikari N, et al. RIP140 contributes to foam cell formation and atherosclerosis by regulating cholesterol homeostasis in macrophages[J]. J Mol Cell Cardiol, 2015, 79:287-294.
[10] Wang Q, Chen K, Zhang F, et al. TRPA1 regulates macrophages phenotype plasticity and atherosclerosis progression[J]. Atherosclerosis, 2020, 301(301):44-53.
[11] 谢洪祥. TRPA1在冠心病患者外周血单核细胞中的表达与 冠脉病变程度的相关性研究[D]. 成都:成都医学院, 2018．
[12] Wang Z, Xu Y, Wang M, et al. TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice[J]. EBioMedicine, 2018, 36(36):54-62.
[13] Shang S, Zhu F, Liu B, et al. Intracellular TRPA1 mediates Ca2＋ release from lysosomes in dorsal root ganglion neurons[J]. J Cell Biol, 2016, 215(3):369-381.
[14] Andrei SR, Ghosh M, Sinharoy P, et al. TRPA1 ion channel stimulation enhances cardiomyocyte contractile function via a CaMKⅡ-dependent pathway[J]. Channels (Austin), 2017, 11(6):587-603.
[15] Roe AT, Frisk M, Louch WE. Targeting cardiomyocyte Ca2＋ homeostasis in heart failure[J]. Curr Pharm Des, 2015, 21(4):431-448.
[16] Wang Z, Ye D, Ye J, et al. The TRPA1 channel in the cardiovascular system: promising features and challenges[J]. Front Pharmacol, 2019, 10(10):1253.
[17] Yamamoto S, Shimizu S. Significance of TRP channels in oxidative stress[J]. Eur J Pharmacol, 2016, 793(11):109-111.
[18] 赵丹, 王沛坚, 周鹏. TRPA1/TRPV1在心血管疾病中的作用[J]. 成都医学院学报, 2019, 14(6):819-822．
[19] Li R, Liu R, Yan F, et al. Inhibition of TRPA1 promotes cardiac repair in mice after myocardial infarction[J]. J Cardiovasc Pharmacol, 2020, 75(3):240-249.
[20] Conklin DJ, Guo Y, Nystoriak MA, et al. TRPA1 Channel contributes to myocardial ischemia-reperfusion injury[J]. Am J Physiol Heart Circ Physiol, 2019, 316(4):H889-H899.
[21] Ma Y, Halade GV, Lindsey ML. Extracellular matrix and fibroblast communication following myocardial infarction[J]. J Cardiovasc Transl Res, 2012, 5(6):848-857.
[22] He ML, Liu WJ, Sun HY, et al. Effects of ion channels on proliferation in cultured human cardiac fibroblasts[J]. J Mol Cell Cardiol, 2011, 51(2):198-206.
[23] Okada Y, Shirai K, Reinach PS, et al. TRPA1 is required for TGF-β signaling and its loss blocks inflammatory fibrosis in mouse corneal stroma[J]. Lab Invest, 2014, 94(9):1030-1041.
[24] Oguri G, Nakajima T, Yamamoto Y, et al. Effects of methylglyoxal on human cardiac fibroblast: roles of transient receptor potential ankyrin 1 (TRPA1) channels[J]. Am J Physiol Heart Circ Physiol, 2014, 307(9):H1339-H1352.
[25] 王震. TRPA1在心肌肥厚中的作用及其机制研究[D]. 武汉: 武汉大学, 2019.
[26] Monrad M, Sajadieh A, Christensen JS, et al. Long-term exposure to traffic-related air pollution and risk of incident atrial fibrillation: a cohort study[J]. Environ Health Perspect, 2017, 125(3):422-427.
[27] Wu Z, He EY, Scott GI, et al. α,β-Unsaturated aldehyde pollutant acrolein suppresses cardiomyocyte contractile function: role of TRPV1 and oxidative stress[J]. Environ Toxicol, 2015, 30(6):638-647.
[28] Kurhanewicz N, Mcintosh-Kastrinsky R, Tong H, et al. TRPA1 mediates changes in heart rate variability and cardiac mechanical function in mice exposed to acrolein[J]. Toxicol Appl Pharmacol, 2017, 324(10):51-60.
[29] Kurhanewicz N, Ledbetter A, Farraj A, et al. TRPA1 mediates the cardiac effects of acrolein through parasympathetic dominance but also sympathetic modulation in mice[J]. Toxicol Appl Pharmacol, 2018, 347(3):104-114.

备注/Memo

备注/Memo:
通信作者：杨骄霞， E-mail：jiaoxiayang1977@163.com
更新日期/Last Update: 2022-10-01