|本期目录/Table of Contents|

[1]左广锋,谢浩,任晓敏,等.血管生成素样蛋白-2，在急性冠脉综合征患者中的表达及其临床意义[J].国际心血管病杂志,2022,01:48-52.
　ZUO Guangfeng,XIE Hao,REN Xiaomin,et al.Expression of serum angiopoietin-like protein 2 in patients with acute coronary syndrome and clinical significance[J].International Journal of Cardiovascular Disease,2022,01:48-52.
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血管生成素样蛋白-2，在急性冠脉综合征患者中的表达及其临床意义(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2022年01期
页码:
48-52
栏目:
临床研究
出版日期:
2022-02-10

文章信息/Info

Title:
Expression of serum angiopoietin-like protein 2 in patients with acute coronary syndrome and clinical significance
作者:
左广锋; 谢浩; 任晓敏; 葛清; 金国珍; 朱琳琳
作者单位：210006 南京医科大学附属南京医院（南京市第一医院）心内科
Author(s):
ZUO Guangfeng;  XIE Hao;  REN Xiaomin;  GE Qing;  JIN Guozhen;  ZHU Linlin
Department of cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
关键词:
血管生成素样蛋白-2 ; 急性冠脉综合征; 内皮炎性反应
Keywords:
Angiopoietin-like protein 2;  Acute coronary syndrome;  Endothelial inflammation
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2022.01.013
文献标识码:
-
摘要:
目的：探讨急性冠脉综合征（ACS）患者血清中促炎性因子血管生成素样蛋白-2 （Angptl-2）的表达及其临床意义。方法：采用酶联免疫吸附方法（ELISA）检测182 例ACS 患者和30 例对照组血清中Angptl-2、白细胞介素-6（IL-6）及可溶性细胞间黏附分子-1 （sICAM-1）水平，通过受试者工作特征曲线（ROC）分析血清Angptl-2 水平对ACS 的诊断 价值。人重组Angptl-2 蛋白干预人冠状动脉内皮细胞（HCAEC）后，采用蛋白印迹法检测 内皮细胞 IL-6 及ICAM-1
Abstract:
Objective: To investigate the expression level and clinical significance of serum angiopoietin-like protein 2 (Angptl-2), which is a kind of serum proinflammatory cytokine, in patients with acute coronary syndrome (ACS). Methods：Enzyme-linked immunosorben

参考文献/References

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[11] Caland L, Labbé P, Mamarbachi M, et al. Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice[J]. Aging (Albany NY), 2019, 11(11):3832-3850.
[12] Sugimoto K, Nakamura T, Tokunaga T, et al. Angiopoietinlike protein 2 induces synovial inflammation in the facet joint leading to degenerative changes via interleukin-6 secretion[J]. Asian Spine J, 2019, 13(3):368-376.
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备注/Memo

备注/Memo:
基金项目：南京市医学科技发展一般性课题（YKK18096）
通信作者：朱琳琳， E-mail:zhulinlin_007@sina.com
更新日期/Last Update: 2022-02-10