索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]魏荧,孙丽,刘洋,等.外泌体在糖尿病心肌病中的研究进展[J].国际心血管病杂志,2022,01:9-13.
点击复制

外泌体在糖尿病心肌病中的研究进展(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2022年01期
页码:
9-13
栏目:
综述
出版日期:
2022-02-10

文章信息/Info

Title:
-
作者:
魏荧孙丽刘洋李悦
作者单位:150001 哈尔滨医科大学附属第一医院心血管内科
Author(s):
-
关键词:
糖尿病心肌病外泌体代谢重构
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2022.01.003
文献标识码:
-
摘要:
糖尿病心肌病是糖尿病患者的主要死亡原因之一,发病机制尚不明确。外泌体 具有细胞通讯作用,其携带生物活性物质通过旁分泌影响靶细胞及器官表型,参与糖尿病心 肌病的发生发展。外泌体可用于靶向药物载体和干细胞疗法,该文从外泌体参与糖尿病心肌 病发病机制出发,介绍外泌体在糖尿病心肌病诊疗中的研究进展。
Abstract:
-

参考文献/References

[1] Ritchie RH, Abel ED. Basic mechanisms of diabetic heart disease[J]. Circ Res, 2020, 126(11):1501-1525.
[2] Jia GH, Hill MA, Sowers JR. Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity[J]. Circ Res, 2018, 122(4):624-638.
[3] Nirengi S, Peres Valgas da Silva C, Stanford KI. Disruption of energy utilization in diabetic cardiomyopathy; a mini review[J]. Curr Opin Pharmacol, 2020, 54:82-90.
[4] Yang D, Zhang W, Zhang HY, et al. Progress, opportunity, and perspective on exosome isolation-efforts for efficient exosomebased theranostics[J]. Theranostics, 2020, 10(8):3684-3707.
[5] Thomou T, Ma MR, Dreyfuss JM, et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues[J]. Nature, 2017, 542(7642):450-455.
[6] De Abreu RC, Fernandes H, Da Costa MP, et al. Native and bioengineered extracellular vesicles for cardiovascular therapeutics[J]. Nat Rev Cardiol, 2020, 17(11):685-697.
[7] Chong CR, Clarke K, Levelt E. Metabolic remodeling in diabetic cardiomyopathy[J]. Cardiovasc Res, 2017, 113(4):422-430.
[8] Katayama M, Wiklander O, Fritz T, et al. Circulating exosomal miR-20b-5p is elevated in type 2 diabetes and could impair insulin action in human skeletal muscle[J]. Diabetes, 2019, 68(3): 515-526.
[9] Casta?o C, Kalko S, Novials A, et al. Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice[J]. Proc Natl Acad Sci U S A, 2018, 115(48):12158- 12163.
[10] Yu Y, Du H, Wei S, et al. Adipocyte-derived exosomal mir-27a induces insulin resistance in skeletal muscle through repression of PPARγ[J]. Theranostics, 2018, 8(8):2171-2188.
[11] Ying W, Riopel M, Bandyopadhyay G, et al. Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity[J]. Cell, 2017, 171(2):372-384.
[12] Wen Z, Li J, Fu Y, et al. Hypertrophic adipocyte-derived exosomal miR-802-5p contributes to insulin resistance in cardiac myocytes through targeting HSP60[J]. Obesity (Silver Spring), 2020, 28(10):1932-1940.
[13] Kobayashi Y, Eguchi A, Tempaku M, et al. Circulating extracellular vesicles are associated with lipid and insulin metabolism[J]. Am J Physiol Endocrinol Metab, 2018, 315(4): E574-E582.
[14] Garcia NA, Moncayo-Arlandi J, Sepulveda P, et al. Cardiomyocyte exosomes regulate glycolytic flux in endothelium by direct transfer of GLUT transporters and glycolytic enzymes[J]. Cardiovasc Res, 2016, 109(3):397-408.
[15] Li HP, Fan JH, Zhao YR, et al. Nuclear miR-320 mediates diabetes-induced cardiac dysfunction by activating transcription of fatty acid metabolic genes to cause lipotoxicity in the heart[J]. Circ Res, 2019, 125(12):1106-1120.
[16] Peterson LR, Gropler RJ. Metabolic and molecular imaging of the diabetic cardiomyopathy[J]. Circ Res, 2020, 126(11):1628- 1645.
[17] de Gonzalo-Calvo D, van der Meer RW, Rijzewijk LJ, et al. Serum microRNA-1 and microRNA-133a levels reflect myocardial steatosis in uncomplicated type 2 diabetes[J]. Sci Rep, 2017, 7(1):47.
[18] Lee JE, Moon PG, Lee IK, et al. Proteomic analysis of extracellular vesicles released by adipocytes of otsuka Long- Evans tokushima fatty (OLETF) rats[J]. Protein J, 2015, 34(3): 220-235.
[19] Montgomery MK. Mitochondrial dysfunction and diabetes: Is mitochondrial transfer a friend or foe?[J]. Biology (Basel), 2019, 8(2):33.
[20] Zhang H, Liu J, Qu D, et al. Serum exosomes mediate delivery of arginase 1 as a novel mechanism for endothelial dysfunction in diabetes[J]. Proc Natl Acad Sci U S A, 2018, 115(29): E6927-E6936.
[21] Wang X, Huang W, Liu G, et al. Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells[J]. J Mol Cell Cardiol, 2014, 74:139-150.
[22] Hu J, Wang S, Xiong Z, et al. Exosomal Mst1 transfer from cardiac microvascular endothelial cells to cardiomyocytes deteriorates diabetic cardiomyopathy[J]. Biochim Biophys Acta Mol Basis Dis, 2018, 1864(11):3639-3649.
[23] Marwick TH, Ritchie R, Shaw JE, et al. Implications of underlying mechanisms for the recognition and management of diabetic cardiomyopathy[J]. J Am Coll Cardiol, 2018, 71(3):339-351.
[24] Lyu L, Wang H, Li B, et al. A critical role of cardiac fibroblastderived exosomes in activating renin angiotensin system in cardiomyocytes[J]. J Mol Cell Cardiol, 2015, 89(Pt B):268- 279.
[25] Yang J, Yu XF, Xue F, et al. Exosomes derived from cardiomyocytes promote cardiac fibrosis via myocytefibroblast cross-talk[J]. Am J Transl Res, 2018, 10(12):4350- 4366.
[26] Zou T, Zhu M, Yc M, et al. MicroRNA-410-5p exacerbates high-fat diet-induced cardiac remodeling in mice in an endocrine fashion[J]. Sci Rep, 2018, 8(1):8780.
[27] Govindappa PK, Patil M, Garikipati V, et al. Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart[J]. FASEB J, 2020, 34(2):2238- 2251.
[28] Li J, Salvador AM, Li G, et al. Mir-30d regulates cardiac remodeling by intracellular and paracrine signaling[J]. Circ Res, 2021, 128(1):e1-e23.
[29] Chaturvedi P, Kalani A, Medina I, et al. Cardiosome mediated regulation of MMP9 in diabetic heart: role of mir29b and mir455 in exercise[J]. J Cell Mol Med, 2015, 19(9):2153- 2161.
[30] Prattichizzo F, Matacchione G, Giuliani A, et al. Extracellular vesicle-shuttled miRNAs: a critical appraisal of their potential as nano-diagnostics and nano-therapeutics in type 2 diabetes mellitus and its cardiovascular complications[J]. Theranostics, 2021, 11(3):1031-1045.
[31] Perdomo L, Vidal-Gómez X, Soleti R, et al. Large extracellular vesicle-associated rap1 accumulates in atherosclerotic plaques, correlates with vascular risks and is involved in atherosclerosis[J]. Circ Res, 2020, 127(6):747-760.
[32] St?pień E?, Durak-Kozica M, Kamińska A, et al. Circulating ectosomes: determination of angiogenic microRNAs in type 2 diabetes[J]. Theranostics, 2018, 8(14):3874-3890.
[33] Pofi R, Giannetta E, Galea N, et al. Diabetic cardiomiopathy progression is triggered by miR122-5p and involves extracellular matrix: a 5-year prospective study[J]. JACC Cardiovasc Imaging, 2021, 14(6):1130-1142.
[34] Tao L, Huang X, Xu M, et al. Value of circulating miRNA-21 in the diagnosis of subclinical diabetic cardiomyopathy[J]. Mol Cell Endocrinol, 2020, 518:110944.
[35] Wang X, Gu H, Huang W, et al. Hsp20-mediated activation of exosome biogenesis in cardiomyocytes improves cardiac function and angiogenesis in diabetic mice[J]. Diabetes, 2016, 65(10):3111-3128.
[36] Gan L, Xie D, Liu J, et al. Small extracellular microvesicles mediated pathological communications between dysfunctional adipocytes and cardiomyocytes as a novel mechanism exacerbating ischemia/reperfusion injury in diabetic mice[J]. Circulation, 2020, 141(12):968-983.
[37] Balbi C, Vassalli G. Exosomes: beyond stem cells for cardiac protection and repair[J]. Stem Cells, 2020, 38(11):1387-1399.
[38] Barile L, Lionetti V, Cervio E, et al. Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction[J]. Cardiovasc Res, 2014, 103(4):530-541.
[39] Huang G, Garikipati V, Zhou Y, et al. Identification and comparison of hyperglycemia-induced extracellular vesicle transcriptome in different mouse stem cells[J]. Cells, 2020, 9(9):2098.
[40] Lin Y, Zhang F, Lian XF, et al. Mesenchymal stem cell-derived exosomes improve diabetes mellitus-induced myocardial injury and fibrosis via inhibition of TGF-β1/Smad2 signaling pathway[J]. Cell Mol Biol, 2019, 65(7):123-126.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81800332)
通信作者:李悦,E-mail:ly99ly@vip.163.com
更新日期/Last Update: 2022-02-10