|本期目录/Table of Contents|

[1]乔祺,杨晨曦,顾佳宁,等.KLF15基因突变导致心房颤动的机制[J].国际心血管病杂志,2021,01:53-57.
　QIAO Qi,YANG Chenxi,GU Jianing,et al.Mechanism of atrial fibrillation induced by KLF15 mutation[J].International Journal of Cardiovascular Disease,2021,01:53-57.
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KLF15基因突变导致心房颤动的机制(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2021年01期
页码:
53-57
栏目:
临床研究
出版日期:
2021-01-20

文章信息/Info

Title:
Mechanism of atrial fibrillation induced by KLF15 mutation
作者:
乔祺; 杨晨曦; 顾佳宁; 柯尊平; 杨奕清; 徐迎佳
200240 复旦大学附属上海市第五人民医院心内科,闵行区复杂心律失常中心,心血管研究室
Author(s):
QIAO Qi;  YANG Chenxi;  GU Jianing;  KE Zunping;  YANG Yiqing;  XU Yingjia
Department of Cardiology, Minhang Center for Complex Cardiac Arrhythmias, Cardiovascular Research Laboratory, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China
关键词:
心房颤动;  遗传学;  转录因子;  KLF15;  报告基因分析
Keywords:
Atrial fibrillation;  Genetics;  Transcriptional factor;  KLF15;  Reporter gene assay
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2021.01.013
文献标识码:
-
摘要:
目的:探讨KLF15基因突变导致心房颤动(房颤)的机制。方法:收集152例特发性房颤患者和206名健康对照者的临床数据和血标本,提取基因组DNA。测序分析KLF15基因以寻找致房颤突变。克隆KLF15基因,构建其野生型和突变型表达质粒,转染培养的HeLa细胞,应用双荧光报告基因分析系统研究突变体的功能特点。结果:在1例特发性房颤患者中发现KLF15基因新突变c.946G>T(p.Glu316X),该突变不存在于206名对照者中。功能分析表明该突
Abstract:
Objective:To explore the mechanism of atrial fibrillation(AF)resulted from a mutation in the KLF15 gene.Methods:Clinical data and peripheral venous blood samples were collected from 152 unrelated patients affected with idiopathic AF and 206 unrelat

参考文献/References

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备注/Memo

备注/Memo:
基金项目:上海市闵行区自然科学基金(2018MHZ072,2019MHZ014,2020MHZ041); 上海市卫生健康委员会基金(201740064)
通信作者:徐迎佳,E-mail:xuyingjia@5thhospital.com
更新日期/Last Update: 2021-01-20