|本期目录/Table of Contents|

[1]吕瑾,刘长召,华晓芳,等.花旗松素在小鼠心肌肥厚及纤维化中的作用及机制研究[J].国际心血管病杂志,2020,06:360.
　LV Jin,LIU Changzhao,HUA Xiaofang,et al.Effect and mechanism of taxifolin on cardiac hypertrophy and fibrosis in mice[J].International Journal of Cardiovascular Disease,2020,06:360.
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花旗松素在小鼠心肌肥厚及纤维化中的作用及机制研究(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2020年06期
页码:
360
栏目:
基础研究
出版日期:
2020-12-15

文章信息/Info

Title:
Effect and mechanism of taxifolin on cardiac hypertrophy and fibrosis in mice
作者:
吕瑾; 刘长召; 华晓芳; 杨胜祥
445000 恩施土家族苗族自治州中心医院内科心血管病中心
Author(s):
LV Jin;  LIU Changzhao;  HUA Xiaofang;  YANG Shengxiang
Department of Cardiology, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei 445000, China
关键词:
花旗松素;  心肌肥厚;  心肌纤维化;  炎性反应;  STAT3
Keywords:
Taxifolin;  Cardiac hypertrophy;  Cardiac fibrosis;  Inflammation;  STAT3
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2020.06.011
文献标识码:
A
摘要:
目的:探讨花旗松素(taxifolin,TXL)在压力负荷诱导的小鼠心肌肥厚及纤维化中的作用及机制。方法:通过主动脉缩窄术(AB)构建心肌肥厚及纤维化小鼠模型,采用随机数表法,将30只雄性C57/B6小鼠(6～8周)随机分为假手术组、AB组及AB+TXL组,每组10只。AB+TXL组小鼠在AB术后第2天给予TXL(20 mg/kg)灌胃处理,共8周。超声心动图检测小鼠心脏功能,HE染色及PSR染色评估小鼠心脏组织肥厚及纤维化情况; 实时聚合酶链反应(qRT-PCR)检测心肌组织ANP、Ctgf及白细胞介素
Abstract:
Objective:To investigate the effect and mechanism of taxifolin(TXL)on cardiac hypertrophy and fibrosis induced by pressure overload in mice.Methods:Aortic banding(AB)was used to construct a model of cardiac hypertrophy and fibrosis in mice. Using a random

参考文献/References

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备注/Memo

备注/Memo:
通信作者:刘长召,E-mail:372465257@qq.com
更新日期/Last Update: 2020-12-15