索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]景昱 王宣春.巨噬细胞内脂质代谢及泡沫细胞形成机制的研究进展[J].国际心血管病杂志,2020,03:143-147.
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巨噬细胞内脂质代谢及泡沫细胞形成机制的研究进展(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2020年03期
页码:
143-147
栏目:
综述
出版日期:
2020-06-08

文章信息/Info

Title:
-
作者:
景昱 王宣春
200040 上海,复旦大学附属华山医院内分泌科
Author(s):
-
关键词:
动脉粥样硬化;  巨噬细胞;  泡沫细胞
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2020.03.005
文献标识码:
-
摘要:
动脉粥样硬化是以动脉内膜下胆固醇积聚为特征的慢性疾病。泡沫细胞是构成动脉粥样斑块的主要成分,大多由于巨噬细胞内脂质代谢紊乱引起。巨噬细胞通过胞饮、清道夫受体介导的方式吞噬胞外胆固醇,在胆固醇酰基转移酶1(ACAT1)和中性胆固醇酯水解酶(nCEH)作用下维持细胞内脂质平衡,多余的胆固醇可以通过ATP结合盒转运体A1(ABCA1)、ATP结合盒转运体G1(ABCG1)和清道夫受体B1(SR-B1)排出。该文介绍巨噬细胞内胆固醇摄取、酯化水解和外溢过程,以及泡沫细胞形成的机制。
Abstract:
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参考文献/References

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81873645)
作者单位:200040 上海,复旦大学附属华山医院内分泌科
通信作者:王宣春,E-mail:wangxch@fudan.edu.cn
更新日期/Last Update: 2020-06-08