索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]张晓晴 李树仁 牛绍乾.ACE2与新型冠状病毒肺炎[J].国际心血管病杂志,2020,02:68-70.
点击复制

ACE2与新型冠状病毒肺炎(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2020年02期
页码:
68-70
栏目:
新型冠状病毒专题
出版日期:
2020-03-29

文章信息/Info

Title:
-
作者:
张晓晴 李树仁 牛绍乾
050017 石家庄,河北医科大学研究生院(张晓晴,牛绍乾); 050000 石家庄,河北省人民医院心内科(李树仁)
Author(s):
-
关键词:
2019新型冠状病毒;  血管紧张素转化酶2;  2019新型冠状病毒肺炎
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2020.02.002
文献标识码:
-
摘要:
研究表明,血管紧张素转化酶(ACE)2很可能是2019新型冠状病毒(2019-nCoV)感染细胞的介导受体。ACE2在肺脏大多表达于Ⅱ型肺泡细胞,Ⅱ型肺泡细胞中ACE2的大量表达可能解释2019新型冠状病毒肺炎(COVID-19)中的肺部损伤。既往研究证实,ACE、血管紧张素Ⅱ、Ang Ⅱ的高表达加重肺损伤,而ACE2对于肺损伤有保护作用,但目前尚无证据表明针对ACE及ACE2的治疗可有效缓解COVID-19。
Abstract:
-

参考文献/References

[ 1 ] WHO.(2020)Clinical management of severe acute respiratory infection when Novel coronavirus(nCoV)infection is suspected-Interim Guidance[EB/OL].[2020-02-10]. https://www.who.int/health-topics/coronavirus.
[ 2 ] Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. Lancet, 2020, 395(10223):497-506.
[ 3 ] World Health Organization. WHO Director-General'sremarks at the media briefing on 2019-nCoV on 11 February 2020[EB/OL].[2020-02-11].https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020.
[ 4 ] 靳英辉, 蔡林, 程真顺, 等. 新型冠状病毒(2019-nCoV)感染的肺炎诊疗快速建议指南(标准版)[J]. 解放军医学杂志, 2020, 45(1):1-20.
[ 5 ] Xu X, Chen P, Wang J, et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission[J]. Sci China Life Sci, 2020, 63(3):457-460.
[ 6 ] 张云海, 宫丽崑, 任进. 血管紧张素转换酶2在SARS病理途径中的作用[J]. 中国药理学与毒理学杂志, 2007, 21(1):72-76.
[ 7 ] Li W, Moore MJ, Vasilieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus[J]. Nature, 2003, 426(6965):450-454.
[ 8 ] Peng Zhou, Xing-Lou Yang, Xian-Guang Wang, et al. Discovery of a novel coronavirus associated with the recent pneumoniaoutbreakinhumans and its potential bat origin[J/OL]. bioRxiv[2020-02-08]. https://doi.org/10.1101/2020.01.22.914952.
[ 9 ] Donoghue M, Hsieh F, Baronas E, et al. A novel angiotensin-converting enzyme-related carboxypeptidase(ACE2)converts angiotensin I to angiotensin 1-9[J]. Circ Res, 2000, 87(5):E1-E9.
[10] Tipnis SR, Hooper NM, Hyde R, et al. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase[J]. J Biol Chem, 2000, 275(43):33238-33243.
[11] 陈立男, 杨秀红. 局部肾素-血管紧张素系统稳态失衡与急性肺损伤[J]. 生理科学进展, 2013, 44(2):133-137.
[12] Castardeli C, Sartório CL, Pimentel EB, et al. The ACE 2 activator diminazene aceturate(DIZE)improves left ventricular diastolic dysfunction following myocardial infarction in rats[J]. Biomed Pharmacother, 2018, 107:212-218.
[13] Yu Zhao, Zixian Zhao, Yujia Wang, et al. Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCoV[J/OL]. bioRxiv [2020-02-10].http://dx.doi.org/10.1101/2020.01.26.919985.
[14] Sweeney RM, McAuley DF. Acute respiratory distress syndrome[J]. Lancet, 2016, 388(10058):2416-2430.
[15] Wösten-van Asperen RM, Lutter R, Specht PA, et al. Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7)or an angiotensin Ⅱ receptor antagonist[J]. J Pathol, 2011, 225(4):618-627.
[16] Kuba K, Imai Y, Rao S, et al. A crucial role of angiotensin converting enzyme 2(ACE2)in SARS coronavirus-induced lung injury[J]. Nat Med, 2005, 11(8):875-879.
[17] Imai Y, Kuba K, Rao S, et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure[J]. Nature, 2005, 436(747):112-116.
[18] 刘和亮, 赵金垣. 血管紧张素转换酶抑制剂对化学性急性呼吸窘迫综合征治疗作用的实验研究[J]. 中华预防医学杂志, 2002, 36(2):93-97.
[19] Neyrinck AP, Matthay MA. The role of angiotensin-converting enzyme inhibition in endotoxin-induced lung injury in rats[J]. Crit Care Med, 2009, 37(2):776-777.

备注/Memo

备注/Memo:

作者单位:050017 石家庄,河北医科大学研究生院(张晓晴,牛绍乾); 050000 石家庄,河北省人民医院心内科(李树仁)
通信作者:李树仁,E-mail:lsr64@126.com
更新日期/Last Update: 2020-03-30