[ 1 ] Xiao Y, Peng H, Hong C, et al. PDGF promotes the warburg effect in pulmonary arterial smooth muscle cells via activation of the PI3K/AKT/mTOR/HIF-1α signaling pathway[J]. Cell Physiol Biochem, 2017, 42(4):1603-1613.
[ 2 ] Paulin R, Michelakis ED. The metabolic theory of pulmonary arterial hypertension[J]. Circ Res, 2014, 115(1):148-164.
[ 3 ] Zhang R, Jing ZC. Energetic metabolic roles in pulmonary arterial hypertension and right ventricular remodeling[J]. Curr Pharm Des, 2016, 22(31):4780-4795.
[ 4 ] Xiong YL, Wang MX, Zhao JB, et al. Sirtuin 3: a Janus face in cancer[J]. Int J Oncol, 2016, 49(6):2227-2235.
[ 5 ] Koppenol WH, Bounds PL, Dang CV. Otto warburg's contributions to current concepts of cancer metabolism[J]. Nat Rev Cancer, 2011, 11(5):325-337.
[ 6 ] Archer SL, Gomberg-Maitland M, Maitland ML, et al. Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer[J]. Am J Physiol Heart Circ Physiol, 2008, 294(2):H570-H578.
[ 7 ] Anderson KA, Green MF, Huynh FK, et al. Snapshot: mammalian sirtuins[J]. Cell, 2014, 159(4):956.
[ 8 ] Li R, Quan Y, Xia W. SIRT3 inhibits prostate cancer metastasis through regulation of FOXO3A by suppressing Wnt/β-catenin pathway[J]. Exp Cell Res, 2018, 364(2):143-151.
[ 9 ] Paulin R, Dromparis P, Sutendra G, et al. Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans[J]. Cell Metab, 2014, 20(5):827-839.
[10] Wei T, Huang G, Gao J, et al. Sirtuin 3 deficiency accelerates hypertensive cardiac remodeling by impairing angiogenesis[J]. J Am Heart Assoc, 2017, 6(8):e006114.
[11] Ansari A, Rahman MS, Saha SK, et al. Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease[J]. Aging Cell, 2017, 16(1):4-16.
[12] Fan J, Shan CL, Kang HB, et al. Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex[J]. Mol Cell, 2014, 53(4):534-548.
[13] Zou XH, Zhu YE, Park SH, et al. SIRT3-mediated dimerization of IDH2 directs cancer cell metabolism and tumor growth[J]. Cancer Res, 2017, 77(15):3990-3999.
[14] Cimen H, Han MJ, Yang YJ, et al. Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria[J]. Biochemistry, 2010, 49(2):304-311.
[15] Ozden O, Park SH, Wagner BA, et al. SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells[J]. Free Radic Biol Med, 2014, 76:163-172.
[16] Zhang XK, Ji RP, Liao XH, et al. MicroRNA-195 regulates metabolism in failing myocardium via alterations in sirtuin 3 expression and mitochondrial protein acetylation[J]. Circulation, 2018, 137(19):2052-2067.