索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]赤小仙 赵庆斌 卫慧羿 李超 刘北彦.Elabela/APJ信号通路在心血管系统中的作用[J].国际心血管病杂志,2018,04:208-210.
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Elabela/APJ信号通路在心血管系统中的作用(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2018年04期
页码:
208-210
栏目:
综述
出版日期:
2018-07-25

文章信息/Info

Title:
-
作者:
赤小仙 赵庆斌 卫慧羿 李超 刘北彦
Author(s):
-
关键词:
Elabela APJ apelin 心血管系统
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2018.04.005
文献标识码:
-
摘要:
G蛋白偶联受体APJ和它的同源配体apelin在人体内广泛表达,具有促进血管生成,调节心血管功能、体液平衡和能量代谢的功能。Elabelas是APJ的新型内源性肽类配体,在胚胎发育和成年期的多种生理及病理过程中发挥重要作用。该文介绍Elabela在心血管系统中的作用,包括促进血管生成、调节心脏和血管功能、抗高血压等
Abstract:
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参考文献/References


[1] Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor[J]. Biochem Biophys Res Commun, 1998, 251(2):471-476.
[2] Szokodi I, Tavi P, Földes G, et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility[J]. Circ Res, 2002, 91(5):434-440.
[3] Scimia MC, Hurtado C, Ray S, et al. APJ acts as a dual receptor in cardiac hypertrophy[J]. Nature, 2012, 488(7411):394-398.
[4] Koguchi W, Kobayashi N, Takeshima H, et al. Cardioprotective effect of apelin-13 on cardiac performance and remodeling in end-stage heart failure[J]. Circ J, 2012, 76(1):137-144.
[5] Wei L, Hou X, Tatemoto K. Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 adipocytes[J]. Regul Pept, 2005, 132(1/3):27-32.
[6] Boucher J, Masri B, Daviaud D, et al. Apelin, a newly identified adipokine up-regulated by insulin and obesity[J]. Endocrinology, 2005, 146(4):1764-1771.
[7] Kumar P, Ashokan A, Aradhyam GK. Apelin binding to human APJ receptor leads to biased signaling[J]. Biochim Biophys Acta, 2016, 1864(12):1748-1756.
[8] Roberts EM, Pope GR, Newson MJ, et al. Stimulus-specific neuroendocrine responses to osmotic challenges in apelin receptor knockout mice[J]. J Neuroendocrinol, 2010, 22(4):301-308.
[9] Chen T, Liu N, Xu GM, et al. Apelin13/APJ promotes proliferation of colon carcinoma by activating Notch3 signaling pathway[J]. Oncotarget, 2017, 8(60):101697-101706.
[10] Chng SC, Ho L, Tian J, et al. ELABELA: a hormone essential for heart development signals via the apelin receptor[J]. Dev Cell, 2013, 27(6):672-680.
[11] Pauli A, Norris ML, Valen E, et al. Toddler: an embryonic signal that promotes cell movement via Apelin receptors[J]. Science, 2014, 343(6172):1248636.
[12] Chaves-Almagro C, Castan-Laurell I, Dray C, et al. Apelin receptors: from signaling to antidiabetic strategy[J]. Eur J Pharmacol, 2015, 763(Pt B):149-159.
[13] Wang Z, Yu D, Wang M, et al. Elabela-apelin receptor signaling pathway is functional in mammalian systems[J]. Sci Rep, 2015, 5:8170.
[14] Deng C, Chen H, Yang N, et al. Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling[J]. J Biol Chem, 2015, 290(30): 18261-18268.
[15] Xu J, Chen L, Jiang Z, et al. Biological functions of Elabela, a novel endogenous ligand of APJ receptor[J]. J Cell Physiol, 2018, 233(9):6472-6482.
[16] Peverelli E, Mantovani G, Lania AG, et al. cAMP in the pituitary: an old messenger for multiple signals[J]. J Mol Endocrinol, 2014, 52(1):R67-R77.
[17] Cui C, Merritt R, Fu L, et al. Targeting Calcium signaling in cancer therapy[J]. Acta Pharm Sin B, 2017, 7(1):3-17.
[18] Ho L, Tan SY, Wee S, et al. ELABELA is an endogenous growth factor that sustains hESC self-renewal via the PI3K/AKT pathway[J]. Cell Stem Cell, 2015, 17(4):435-447.
[19] Goumans MJ, Ten Dijke P. TGF-β signaling in control of cardiovascular function[J]. Cold Spring Harb Perspect Biol, 2018, 10(2):a022210.
[20] Euler-Taimor G, Heger J. The complex pattern of SMAD signaling in the cardiovascular system[J]. Cardiovasc Res, 2006, 69(1):15-25.
[21] Perjes A, Kilpio T, Ulvila J, et al. Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart[J]. Basic Res Cardiol, 2016, 111(1):2.
[22] Yang P, Read C, Kuc RE, et al. Elabela/toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension[J]. Circulation, 2017, 135(12):1160-1173.
[23] Sato T, Sato C, Kadowaki A, et al. ELABELA-APJ axis protects from pressure overload heart failure and angiotensin Ⅱ-induced cardiac damage[J]. Cardiovasc Res, 2017, 113(7):760-769.
[24] Chen H, Wang L, Wang W, et al. ELABELA and an ELABELA fragment protect against AKI[J]. J Am Soc Nephrol, 2017, 28(9):2694-2707.
[25] Touyz RM, He G, El Mabrouk M, et al. Differential activation of extracellular signal-regulated protein kinase 1/2 and p38 mitogen activated-protein kinase by AT1 receptors in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats[J]. J Hypertens, 2001, 19(3 Pt 2):553-559.
[26] Watts SW. 5-Hydroxytryptamine-induced potentiation of endothelin-1- and norepinephrine-induced contraction is mitogen-activated protein kinase pathway dependent[J]. Hypertension, 2000, 35(1 Pt 2):244-248.
[27] Banday AA, Fazili FR, Marwaha A, et al. Mitogen-activated protein kinase upregulation reduces renal D1 receptor affinity and G-protein coupling in obese rats[J]. Kidney Int, 2007, 71(5):397-406.
[28] Wójcicka G, Jamroz-Wis'niewska A, Widomska S, et al. Role of extracellular signal-regulated kinases(ERK)in leptin-induced hypertension[J]. Life Sci, 2008, 82(7/8):402-412.
[29] Touyz RM, Deschepper C, Park JB, et al. Inhibition of mitogen-activated protein/extracellular signal-regulated kinase improves endothelial function and attenuates Ang Ⅱ-induced contractility of mesenteric resistance arteries from spontaneously hypertensive rats[J]. J Hypertens, 2002, 20(6):1127-1134.
[30] Schreiber CA, Holditch SJ, Generous A, et al. Sustained ELABELA gene therapy in high-salt diet-induced hypertensive rats[J]. Curr Gene Ther, 2017, 16(5):349-360.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81200098)
作者单位:710061 西安交通大学第一附属医院老年病科(赤小仙,赵庆斌,卫慧羿,李超); 453100 新乡医学院第一附属医院内分泌科(刘北彦)
通信作者:赵庆斌,Email:zhaoqingbin05@163.com
更新日期/Last Update: 2018-07-30