索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]王玲洁,陆林,张凤如,等.肠道菌群与心力衰竭关系的研究进展[J].国际心血管病杂志,2018,02:76-78.
点击复制

肠道菌群与心力衰竭关系的研究进展

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2018年02期
页码:
76-78
栏目:
综述
出版日期:
2018-03-25

文章信息/Info

Title:
-
作者:
王玲洁; 陆林; 张凤如; 沈卫峰; 张瑞岩
200025 上海交通大学医学院附属瑞金医院心脏科
Author(s):
-
关键词:
心力衰竭;  肠道菌群;  氧化三甲胺;  菌群移植
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2018.02.004
文献标识码:
-
摘要:
肠道菌群与心力衰竭(心衰)密切相关。心衰伴发的血流动力学改变如肠道内低灌注和淤血可改变肠道的形态、通透性、功能以及肠道菌群的生长和组成,进而破坏肠道屏障,出现微生物或内毒素移位,加剧全身炎症反应。肠道菌群的代谢产物氧化三甲胺是偶联肠道菌群与心衰的关键介质。目前针对肠道菌群的干预策略包括饮食调节、抗生素、微生态制剂、菌群移植等,但安全性和有效性尚需证实。
Abstract:
-

参考文献/References

[1] Neish AS. Microbes in gastrointestinal health and disease[J]. Gastroenterology, 2009, 136(1):65-80.
[2] Patterson E, Cryan JF, Fitzgerald GF, et al. Gut microbiota, the pharmabiotics they produce and host health[J]. Proc Nutr Soc, 2014, 73(4):477-489.
[3] Tang WH,Kital T,Hazen SL.Gutmicrobiota in cardiovascular health and disease[J]. Circ Res, 2017, 120(7):1183-1196.
[4] Niebauer J, Volk HD, Kemp M, et al. Endotoxin and immune activation in chronic heart failure: a prospective cohort study[J]. Lancet, 1999, 353(9167):1838-1842.
[5] Sandek A, Bauditz J, Swidsinski A, et al. Altered intestinal function in patients with chronic heart failure[J]. J Am Coll Cardiol, 2007, 50(16):1561-1569.
[6] Peschel T, Schönauer M, Thiele H, et al. Invasive assessment of bacterial endotoxin and inflammatory cytokines in patients with acute heart failure[J]. Eur J Heart Fail, 2003, 5(5):609-614.
[7] Pasini E, Aquilani R, Testa C, et al. Pathogenic gut flora in patients with chronic heart failure[J]. JACC Heart Fail, 2016, 4(3):220-227.
[8] Phillips Campbell RB, Duffourc MM, Schoborg RV, et al. Aberrant fecal flora observed in Guinea pigs with pressure overload is mitigated in animals receiving vagus nerve stimulation therapy[J]. Am J Physiol Gastrointest Liver Physiol, 2016, 311(4):G754-G762.
[9] Bennett BJ, De AguiarVallim TQ, Wang Z, et al. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation[J]. Cell Metab, 2013, 17(1):49-60.
[10] Martin FP, Wang Y, Sprenger N, et al. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model[J]. Mol Syst Biol, 2008, 4(157):1-15.
[11] Ding T, Schloss PD. Dynamics and associations of microbial community types across the human body[J]. Nature, 2014, 509(750):357-360.
[12] Rhee EP, Clish CB, Ghorbani A, et al.A combined epidemiologic and metabolomic approach improves CKD prediction[J]. J Am SocNephrol, 2013, 24(8):1330-1338.
[13] Tang W, Wang ZE, Fan YY, et al. Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure refining the gut hypothesis[J]. J Am Coll Cardiol, 2014, 64(18):1908-1914.
[14] Lever M, George PM, Slow S, et al. Betaine and trimethylamine-N-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: an observational study[J]. PLoS One, 2014, 9(12):e114969.
[15] Suzuki T, Heaney LM, Bhandari SS, et al. Trimethylamine N-oxide and prognosis in acute heart failure[J]. Heart, 2016, 102(11):841-848.
[16] Tang WH, Wang Z, Shrestha K, et al. Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure[J]. J Card Fail, 2015, 21(2):91-96.
[17] Tang WH, Wang Z, Kennedy DJ, et al. Gut microbiota-dependent trimethylamine N-oxide(TMAO)pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease[J]. Circ Res, 2015, 116(3):448-455.
[18] Ufnal M, Jazwiec R, Dadlez M, et al. Trimethylamine-N-oxide:a carnitine-derived metabolite that prolongs the hypertensive effect of angiotensin Ⅱ in rats[J]. Can J Cardiol, 2014, 30(12):1700-1705.
[19] Organ CL, Otsuka H, Bhushan S, et al. Choline diet and its gut microbe-derived metabolite, trimethylamine N-oxide, exacerbate pressure overload-induced heart failure[J]. Circ Heart Fail, 2016, 9(1):e002314.
[20] Estruch R, Ros E, Salas-Salvadó J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet[J]. N Engl J Med, 2013, 368(14):1279-1290.
[21] De Filippis F, Pellegrini N, Vannini L, et al. High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome[J]. Gut, 2016, 65(11):1812-1821.
[22] Koeth RA, Wang ZE, Levison BS, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis[J]. Nat Med, 2013, 19(5):576-585.
[23] Kalambokis GN, Mouzaki A, Rodi M, et al. Rifaximin improves systemic hemodynamics and renal function in patients with alcohol-related cirrhosis and ascites[J]. Clin Gastroenterol Hepatol, 2012, 10(7):815-818.
[24] Lam V, Su J, Koprowski S, et al. Intestinal microbiota determine severity of myocardial infarction in rats[J]. FASEB J, 2012, 26(4):1727-1735.
[25] Conraads VM, Jorens PG, De Clerck LS, et al. Selective intestinal decontamination in advanced chronic heart failure: a pilot trial[J]. Eur J Heart Fail, 2004, 6(4):483-491.
[26] Gan XT, Ettinger G, Huang CX, et al. Probiotic administration attenuates myocardial hypertrophy and heart failure after myocardial infarction in the rat[J]. Circ Heart Fail, 2014, 7(3):491-499.
[27] Costanza AC, Moscavitch SD, Faria Neto HC, et al. Probiotic therapy with Saccharomyces boulardii for heart failure patients: a randomized, double-blind, placebo-controlled pilot trial[J]. Int J Cardiol, 2015, 179:348-350.
[28] Lekawanvijit S, Kompa AR, Manabe M, et al. Chronic kidney disease-induced cardiac fibrosis is ameliorated by reducing circulating levels of a non-dialysable uremic toxin, indoxyl sulfate[J]. PLoS One, 2012, 7(7):e41281.
[29] Fujii H, Nishijima F, Goto S, et al. Oral charcoal adsorbent(AST-120)prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress[J]. Nephrol Dial Transplant, 2009, 24(7):2089-2095.
[30] Gregory JC, Buffa JA, Org E, et al. Transmission of atherosclerosis susceptibility with gut microbial transplantation[J]. J Biol Chem, 2015, 290(9):5647-5660.

备注/Memo

备注/Memo:
通信作者:王玲洁,Email:lingjier@126.com
更新日期/Last Update: 2018-04-20