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《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:

2017年05期

页码:

309-313

栏目:

临床研究

出版日期:

2017-10-20

文章信息/Info

Title:

The role of precision medicine in antiplatelet drug selection after percutaneous coronary intervention

作者:

任聪慧; 孙经武; 刘成洲等

262600 潍坊,临朐县人民医院心内一科(任聪慧,刘成洲); 264100 烟台,滨州医学院烟台附属医院(孙经武); 200032 上海,复旦大学附属中山医院(郎军涛)

Author(s):

REN Conghui¹;  SUN Jingwu²;  LIU Chengzhou¹;  LANG Juntao³

1. People's Hospital of Linqu, Shandong 262600; 2. Yantai Affiliated Hospital of Binzhou Medical University, Shandong 264100; 3. Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China

关键词:

精准医疗;  基因检测;  氯吡格雷;  替格瑞洛

Keywords:

Precision medicine;  Gene detection;  Clopidogrel;  Ticagrelor

分类号:

-

DOI:

10.3969/j.issn.1673-6583.2017.05.016

文献标识码:

-

摘要:

目的:探讨精准医疗、个体化给药在经皮冠状动脉介入术(PCI)后抗血小板药物选择中的作用。方法:入选PCI 后服用常规剂量阿司匹林(100 mg/d)和氯吡格雷(75 mg/d)且疗程在3个月左右的患者,根据CYP2C19基因多态性检测结果 ,将患者分为快代谢组、中代谢组和低代谢组,并给予个体化干预治疗。快代谢组继续服用常规剂量的阿司匹林和氯吡格 雷; 中代谢组将氯吡格雷调整为1.5倍剂量; 低代谢组分为两组,氯吡格雷组将氯吡格雷调整为2倍剂量,替格瑞洛组将氯 吡格雷改换为替格瑞洛(90 mg、2次

Abstract:

Objective:To investigate the role of precision medical and individualized administration of antiplatelet drugs after percutaneous coronary intervention(PCI).Methods:Patients treated with routine dose of aspirin(100 mg/d)and clopidogrel(75 mg/d)after P

参考文献/References

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备注/Memo

备注/Memo:

通信作者:孙经武,Email:bysjw@163.com

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更新日期/Last Update: 2017-10-20