|本期目录/Table of Contents|

[1]胡俊青,张征宇.芦丁抑制氧化低密度脂蛋白诱导的血管平滑肌细胞增殖[J].国际心血管病杂志,2017,05:299-301.
　HU Junqing,ZHANG Zhengyu.Rutin-inhibited proliferation of vascular smooth muscle cells induced by oxidized low-density lipoprotein[J].International Journal of Cardiovascular Disease,2017,05:299-301.
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芦丁抑制氧化低密度脂蛋白诱导的血管平滑肌细胞增殖(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2017年05期
页码:
299-301
栏目:
出版日期:
2017-10-20

文章信息/Info

Title:
Rutin-inhibited proliferation of vascular smooth muscle cells induced by oxidized low-density lipoprotein
作者:
胡俊青; 张征宇
266035 青岛,山东大学齐鲁医院(青岛)药学部(胡俊青); 511436 广州医科大学组织胚胎教研室(张征宇)
Author(s):
HU Junqing;  ZHANG Zhengyu
1. Department of Pharmacy, Qilu Hospital of Shandong University(Qingdao), Shandong 266035; 2. Department of Histology and Embryology, Guangzhou Medical University, Guangdong 511436, China
关键词:
芦丁;  血管平滑肌细胞;  氧化低密度脂蛋白;  增殖
Keywords:
Rutin;  Vascular smooth muscle cells;  Oxidized low-density lipoprotein;  Proliferation
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2017.05.013
文献标识码:
-
摘要:
目的:探讨芦丁在氧化低密度脂蛋白(ox-LDL)诱导的血管平滑肌细胞(VSMC)增殖中的作用。方法:制备ox-LDL, 采用贴壁法分离培养C57BL/6J小鼠的VSMC,将细胞分为对照组、芦丁组、ox-LDL组和芦丁+ox-LDL组,MTT法检测各组VSMC 细胞增殖活性,Western blot检测VSMC中磷酸化细胞外信号调节激酶(p-ERK)的表达情况。结果:芦丁组与对照组细胞增 殖活性及p-ERK蛋白表达水平均无明显差异(P均>0.05); ox-LDL组细胞增殖活性及p
Abstract:
Objective:To investigate the role of rutin in the proliferation of vascular smooth muscle cells(VSMCs)induced by oxidized low-density lipoprotein(ox-LDL).Methods:Ox-LDL was prepared and the VSMCs of C57BL/6J mice were isolated and cultured by adherenc

参考文献/References

[1] Liu J, Ren Y, Kang L, et al. Oxidized low-density lipoprotein increases the proliferation and migration of human coronary artery smooth muscle cells through the upregulation of osteopontin[J]. Int J Mol Med, 2014, 33(5):1341-1347.
[2] Guon TE, Chung HS.Hyperoside and rutin of induce mitochondrial apoptosis through a caspase- dependent mechanism in HT-29 human colon cancer cells[J]. Oncol Lett, 2016, 11(4):2463-2470.
[3] Zhang Z, Zhang M, Li Y, et al. Simvastatin inhibits the additive activation of ERK1/2 and proliferation of rat vascular smooth muscle cells induced by combined mechanical stress and oxLDL through LOX-1 pathway[J]. Cell Signal, 2013, 25(1):332-340.
[4] Aoyama T, Chen M, Fujiwara H, et al.LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells[J]. FEBS Lett, 2000, 467(2/3):217-220.

备注/Memo

备注/Memo:
基金项目:广东省自然基金(2014A030310207)
通信作者:张征宇,Email:zhengyuceo@163.com
更新日期/Last Update: 2017-10-20