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《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:

2017年04期

页码:

231-235

栏目:

出版日期:

2017-07-25

文章信息/Info

Title:

Modeling of interatrial block in swine via radiofrequency catheter ablation in right atrial endocardium

作者:

蔡洁玲; 黄少华; 曹宾; 张雁; 连敏; 陶文其; 俞帅; 陆婷; 顾慧慧

200040 上海,复旦大学附属静安区中心医院(筹)心内科(蔡洁玲,黄少华,曹 宾,张 雁,连 敏,陶文其,俞 帅,陆 婷,顾慧慧,唐 琦,王 琳,王 骏,孙育民); 200040 上海,复旦大学附属华山医院心内科(罗心平)

Author(s):

CAI Jieling¹; HUANG Shaohua¹; CAO Bin¹; ZHANG Yan¹; LIAN Min¹; TAO Wenqi¹; YU Shuai¹; LU Ting¹; GU Huihui¹; TANG Qi¹; WANG Lin¹; LUO Xinping

1. Department of Cardiology, Shanghai Jing'an District Central Hospital, Fudan University, Shanghai 200040; 2. Department of Cardiology, Huashan Hospital affiliated to Fudan University, Shanghai 200040, China

关键词:

射频消融; 右心房; 心房间传导阻滞; 动物模型

Keywords:

Radiofrequency ablation;  Right atrium;  Interatrial block;  Animal model

分类号:

-

DOI:

10.3969/j.issn.1673-6583.2017.04.010

文献标识码:

-

摘要:

目的:探讨经心内膜导管射频消融损伤心房间通路系统建立心房间传导阻滞(interatrialblock,IAB)模型的可行性。方法:对8只实验猪在三维电解剖标测系统指引下,沿右心耳前壁与心房连接处的心房侧(右心房前壁)进行射频消融,再沿右心耳后壁与心房连接处的心房侧(右心房房间隔侧)进行射频消融,记录体表心电图和腔内电图变化,3个月后对消融线径进行组织学检查。结果:8只猪未发生手术相关并发症,5只建模成功。P波宽度从术前的(69±3)ms延长至术后即刻的(116±5)ms和术后3个月的(122±4)ms(与术前相比,P均<0.05)。术后3个月右心房消融线径Masson染色可见胶原纤维或网状纤维组织明显增生。结论:可采用导管射频消融右心房心内膜方法建立心房间传导阻滞猪模型,但有一定失败率。

Abstract:

Objective:To probe the feasibility of modeling interatrial block(IAB)in swine via radiofrequency catheter ablation in right atrial endocardium.Methods:Eight swine underwent radiofrequency catheter ablation under the guidance of three-dimensional electro-anatomical mapping system. The two ablation tracts consisted of the right atrial endocardium, which were close to the front wall of the right atrial appendage and the right atrial septum. Electrocardiogram and intracardiac electrogram were recorded before and after the ablation. Three months later, the ablation tracts were histologically examined.Results:No complications occurred in 8 swine and 5 models were successfully established. The P wave duration extended from(69±3)ms to(116±5)ms(instantly after the ablation)and(122±4)ms(three months later)(compared with the untreated, both P<0.05)in the successfully established models. Masson staining showed that collagen or reticulum fibers greatly proliferated along the ablation tracts in the right atrium three months later.Conclusion:Interatrial block model can be successfully established via radiofrequency catheter ablation in right atrial endocardium, although accompanying with a certain rate of failure.

参考文献/References

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备注/Memo

备注/Memo:

基金项目:上海市自然科学基金(14ZR1436000); 上海市静安区卫生计生系统十百千卫生人才培养项目(JWRC2014D02); 上海市医学重点专科建设项目(ZK2015B13)
通信作者:孙育民,Email:munaiyisun@163.com

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更新日期/Last Update: 2017-07-25