|本期目录/Table of Contents|

[1]许志锋,李敬来,韩振,等.bFGF基因修饰骨骼肌卫星细胞移植对心肌梗死兔心功能的影响[J].国际心血管病杂志,2017,03:157-161.
　XU Zhifeng,LI Jinglai,HAN Zhen,et al.Effects of bFGF-gene modified skeletal muscle satellite cell transplantation on cardiac function of acute myocardial infarction rabbits[J].International Journal of Cardiovascular Disease,2017,03:157-161.
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bFGF基因修饰骨骼肌卫星细胞移植对心肌梗死兔心功能的影响(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2017年03期
页码:
157-161
栏目:
出版日期:
2017-05-30

文章信息/Info

Title:
Effects of bFGF-gene modified skeletal muscle satellite cell transplantation on cardiac function of acute myocardial infarction rabbits
作者:
许志锋; 李敬来; 韩振; 冯钢; 任明明
518036 深圳,北京大学深圳医院心血管外科
Author(s):
XU Zhifeng;  LI Jinglai;  HAN Zhen;  FENG Gang;  REN Mingming
Department of Cardiovascular Surgery, Shenzhen Hospital, Peking University, Guangdong 518036, China
关键词:
骨骼肌卫星细胞;  碱性成纤维细胞生长因子;  基因修饰;  心肌梗死;  干细胞移植;  心功能
Keywords:
Skeletal muscle satellite cell;  Basic fibroblast growth factor;  Gene modification;  Myocardial infarction;  Stem cell transplantation;  Cardiac function
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2017.03.009
文献标识码:
-
摘要:
目的:观察bFGF基因修饰骨骼肌卫星细胞在心肌梗死区存活情况以及对心功能的影响。方法:分离培养兔骨骼肌卫星细胞,构建bFGF基因修饰骨骼肌卫星细胞。建立急性心肌梗死兔模型,随机分为骨骼肌卫星细胞组、bFGF基因修饰骨骼肌卫星细胞组和对照组,每组6只,在各组动物梗死心肌内分别注射骨骼肌卫星细胞、bFGF基因修饰骨骼肌卫星细胞及等量的细胞培养液。造模前及细胞移植4周后,心脏超声测定兔左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、短轴缩短率(FS)和射血分数(EF),观察移植4周后心脏病理切片
Abstract:
Objective:To observe the survival of bFGF gene modified skeletal muscle satellite cells in myocardial infarction areas and the effects on cardiac function.Methods:Rabbit skeletal muscle satellite cells were isolated and bFGF gene modified skeletal muscle

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备注/Memo

备注/Memo:
基金项目:深圳市科技计划项目(200404104)
通信作者:李敬来,Email:15813881823@139.com
更新日期/Last Update: 2017-05-30