|本期目录/Table of Contents|

[1]朱桂平,张莉,周玉良,等.外源性睾酮对雄性小鼠心功能和心脏衰老的影响[J].国际心血管病杂志,2016,06:369-374.
　ZHU Guiping,ZHANG Li,ZHOU Yuliang,et al.The effects of exogenous testosterone on cardiac function and myocardial senescence in male mice[J].International Journal of Cardiovascular Disease,2016,06:369-374.
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外源性睾酮对雄性小鼠心功能和心脏衰老的影响(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2016年06期
页码:
369-374
栏目:
出版日期:
2016-11-20

文章信息/Info

Title:
The effects of exogenous testosterone on cardiac function and myocardial senescence in male mice
作者:
朱桂平; 张莉; 周玉良; 李博维; 林忠伟; 雷达
510080 广州,广东药学院附属第一医院心内科
Author(s):
ZHU Guiping;  ZHANG Li;  ZHOU Yuliang;  LI Bowei;  LIN Zhongwei;  LEI Da.
Department of Cardiology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangdong 510080, China
关键词:
衰老; 睾酮; 心功能不全; 沉默信息调节因子1
Keywords:
Senescence;  Testosterone;  Cardiac dysfunction;  Silent information regulator 1
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2016.06.014
文献标识码:
-
摘要:
目的:探讨外源性睾酮对雄性小鼠心功能和心脏衰老的影响。方法:15个月龄C57/BL6雄性小鼠分为4组:安慰剂组、睾酮组、沉默信息调节因子1(Sirt1)抑制剂EX-527组(EX-527组)和睾酮+EX-527组,每组7只。干预3个月后超声心动图检测小鼠心功能指标,ELISA法检测小鼠血清睾酮浓度,分离小鼠左心室,组织化学染色法检测衰老相关β-半乳糖苷酶(SA-β-gal),Westernblot检测心肌组织B型利钠肽(BNP)、Sirt1蛋白表达水平,实时定量RT-PCR检测心肌组织肌球蛋白重链(MYH
Abstract:
Objective:To investigate the effects of exogenous testosterone on cardiac function and myocardial senescence in male mice.Methods:Twenty-eight 15-month-old male C57/BL6 mice were divided into 4 experimental groups: placebo group, testosterone group, silen

参考文献/References

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备注/Memo

备注/Memo:
基金项目:广东省公益研究与能力建设专项资金(2014A020212305); 广东药学院附属第一医院院内课题 作者单位:510080 广州,广东药学院附属第一医院心内科 通信作者:雷 达,Email:gyleida@163.com
更新日期/Last Update: 2016-11-20