索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]朱政怡,戚彤云,张雪,等.骨架蛋白ENH在心血管系统中作用的研究进展[J].国际心血管病杂志,2016,06:351-354.
点击复制

骨架蛋白ENH在心血管系统中作用的研究进展(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2016年06期
页码:
351-354
栏目:
综述
出版日期:
2016-11-20

文章信息/Info

Title:
-
作者:
朱政怡; 戚彤云; 张雪; 柯越海; 程洪强
310058 杭州,浙江大学基础医学院病理与病理生理学系
Author(s):
-
关键词:
心血管系统; ENH; 骨架蛋白; 锚定蛋白
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2016.06.009
文献标识码:
-
摘要:
ENH是一个含有PDZ和LIM结构域的骨架蛋白,存在多种mRNA剪接体,不同的剪接体具有不同的组织表达方式和功能。ENH在心血管系统中发挥骨架蛋白的结构功能,在心脏发育和维持心脏Z线结构稳定中有重要作用。ENH还能与不同的蛋白激酶结合,作为信号分子的锚定蛋白,调控信号转导,调节心肌细胞的生长、血管平滑肌细胞的增殖与迁移。
Abstract:
-

参考文献/References

[1] Frank D, Frey N. Cardiac Z-disc signaling network[J]. J Biol Chem, 2011,286(12):9897-9904.
[2] Nakagawa N, Hoshijima M, Oyasu M, et al. ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain[J]. Biochem Biophys Res Commun, 2000,272(2):505-512.
[3] te Velthuis AJ, Bagowski CP. PDZ and LIM domain-encoding genes: molecular interactions and their role in development[J]. Scientific World Journal, 2007,7:1470-1492.
[4] Kuroda S, Tokunaga C, Kiyohara Y, et al. Protein-protein interaction of zinc finger LIM domains with protein kinase C[J]. J Biol Chem, 1996, 271(49):31029-31032.
[5] Zheng M, Cheng H, Banerjee I, et al. ALP/Enigma PDZ-LIM domain proteins in the heart[J]. J Mol Cell Biol, 2010,2(2):96-102.
[6] van den Hoogenhof MM, Pinto YM, Creemers EE. RNA splicing: regulation and dysregulation in the heart[J]. Circ Res, 2016,118(3):454-468.
[7] Cheng H, Kimura K, Peter AK, et al. Loss of enigma homolog protein results in dilated cardiomyopathy[J]. Circ Res, 2010,107(3):348-356.
[8] Ito J, Hashimoto T, Nakamura S, et al. Splicing transitions of the anchoring protein ENH during striated muscle development[J]. Biochem Biophys Res Commun, 2012,421(2):232-238.
[9] Niederlander N, Fayein NA, Auffray C, et al. Characterization of a new human isoform of the enigma homolog family specifically expressed in skeletal muscle[J]. Biochem Biophys Res Commun, 2004,325(4):1304-1311.
[10] Yamazaki T, Walchli S, Fujita T, et al. Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy[J]. Cardiovasc Res, 2010, 86(3):374-382.
[11] Ito J, Takita M, Takimoto K, et al. Enigma homolog 1 promotes myogenic gene expression and differentiation of C2C12 cells[J]. Biochem Biophys Res Commun, 2013,435(3):483-487.
[12] Huang C, Zhou Q, Liang P, et al. Characterization and in vivo functional analysis of splice variants of cypher[J]. J Biol Chem, 2003,278(9):7360-7365.
[13] Dixon DM, Choi J, El-Ghazali A, et al. Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms[J]. Sci Rep, 2015,5:9042..
[14] Batra R, Charizanis K, Manchanda M, et al. Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease[J]. Mol Cell, 2014,56(2):311-322.
[15] Mu Y, Jing R, Peter AK, et al. Cypher and Enigma homolog protein are essential for cardiac development and embryonic survival[J]. J Am Heart Assoc, 2015,4(5):e001950.
[16] Bondue A, Lapouge G, Paulissen C, et al. Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification[J]. Cell Stem Cell, 2008,3(1):69-84.
[17] Ewen EP, Snyder CM, Wilson M, et al. The Mef2A transcription factor coordinately regulates a costamere gene program in cardiac muscle[J]. J Biol Chem, 2011,286(34):29644-29653.
[18] Zhou Q, Chu PH, Huang C, et al. Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy[J]. J Cell Biol, 2001,155(4):605-612.
[19] Zhu C, Yu ZB, Chen XH, et al. Screening for differential methylation status in fetal myocardial tissue samples with ventricular septal defects by promoter methylation microarrays[J]. Mol Med Rep, 2011,4(1):137-143.
[20] Bang C, Batkai S, Dangwal S, et al. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy[J]. J Clin Invest, 2014,124(5):2136-2146.
[21] Zhou Q, Ruiz-Lozano P, Martone ME, et al. Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C[J]. J Biol Chem, 1999,274(28):19807-19813.
[22] Maturana AD, Nakagawa N, Yoshimoto N, et al. LIM domains regulate protein kinase C activity: a novel molecular function[J]. Cell Signal, 2011,23(5):928-934.
[23] Ito J, Iijima M, Yoshimoto N, et al. Scaffold protein enigma homolog activates CREB whereas a short splice variant prevents CREB activation in cardiomyocytes[J]. Cell Signal, 2015,27(12):2425-2433.
[24] Lin C, Guo X, Lange S, et al. Cypher/ZASP is a novel A-kinase anchoring protein[J]. J Biol Chem, 2013,288(41):29403-29413.
[25] Maturana AD, Walchli S, Iwata M, et al. Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel[J]. Cardiovasc Res, 2008,78(3):458-465.
[26] Peng Y, Gregorich ZR, Valeja SG, et al. Top-down proteomics reveals concerted reductions in myofilament and Z-disc protein phosphorylation after acute myocardial infarction[J]. Mol Cell Proteomics, 2014,13(10):2752-2764.
[27] Yan Y, Tsukamoto O, Nakano A, et al. Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5[J]. Nat Commun, 2015,6:6137.
[28] Chen T, Zhou G, Zhou Q, et al. Loss of microRNA-17 approximately 92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5[J]. Am J Respir Crit Care Med, 2015,191(6):678-692.
[29] Cheng H, Chen T, Tor M, et al. A High-throughput screening platform targeting PDLIM5 for pulmonary hypertension[J]. J Biomol Screen, 2016, 21(4):333-341.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81170117,31471258) 作者单位:310058 杭州,浙江大学基础医学院病理与病理生理学系 通信作者:程洪强,Email:hqcheng11@zju.edu.cn
更新日期/Last Update: 2016-11-20