|本期目录/Table of Contents|

[1]黄俊玲,罗明,谢南姿,等.血管紧张素转化酶抑制肽LAP改善血压及心室重构的研究[J].国际心血管病杂志,2016,05:295-299.
　HUANG Junling,LUO Ming,XIE Nanzi,et al.The effects of angiotensin-converting enzyme inhibitory peptide LAP to blood pressure and ventricular remodeling[J].International Journal of Cardiovascular Disease,2016,05:295-299.
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血管紧张素转化酶抑制肽LAP改善血压及心室重构的研究(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2016年05期
页码:
295-299
栏目:
出版日期:
2016-09-20

文章信息/Info

Title:
The effects of angiotensin-converting enzyme inhibitory peptide LAP to blood pressure and ventricular remodeling
作者:
黄俊玲; 罗明; 谢南姿; 沈艺; 罗帮镇; 王海峰; 刘阳
200065 上海,同济大学附属同济医院老年科
Author(s):
HUANG Junling;  LUO Ming;  XIE Nanzi;  SHEN Yi;  LUO Bangzhen;  WANG Haifeng;  LIU Yang.
Department of Geriatrics,Tongji Hospital affiliated to Tongji University,Shanghai 200065, China
关键词:
血管紧张素转化酶抑制肽; 高血压; 心室重构
Keywords:
Angiotensin-converting enzyme inhibitory peptide;  Hypertension;  Ventricular remodeling
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2016.05.011
文献标识码:
-
摘要:
目的:探讨血管紧张素转化酶抑制肽LAP的长期降压效果及对心室重构的干预作用。方法:选取10周龄雄性自发性高血压大鼠(spontaneouslyhypertensiverat,SHR)为动物模型,随机分为空白对照组、依那普利组(Ena组)和LAP组。干预时间为8周,干预期间监测SHR的血压变化,干预结束后对SHR的心脏形态、心脏功能、心肌肥厚程度及心肌纤维化指标进行检测。结果:(1)干预2周后LAP组血压明显低于空白对照组(P<0.05),降压效果持续至干预结束;LAP组与Ena组比较血
Abstract:
Objective:To study the protective effects of angiotensin-converting enzyme(ACE)-inhibitory peptide LAP on blood pressure and ventricular remodeling.Methods:Ten-week-old male spontaneously hypertensive rats(SHR)were divided into three groups: blank control

参考文献/References

[1] Katragadda S, Arora RR. Role of angiotensin-converting enzyme inhibitors in vascular modulation: beyond the hypertensive effects[J]. Am J Ther, 2010,17(1):e11-23.
[2] 沈芳芳,邵 湍,申进阁,等.通心络胶囊对扩张型心肌病大鼠心功能和心室重构的影响[J].国际心血管病杂志,2013,40(6):372-375.
[3] Kumarswamy R,Thum T. Non-coding RNAs in cardiac remodeling and heart failure[J].Circ Res,2013,113(6):676-689.
[4] 杨 君,杨 龙,唐 倩,等.替米沙坦在牵张刺激导致的心室肌细胞延迟整流钾通道改变中的作用[J].国际心血管病杂志,2015,42(1):51-57.
[5] Hughes AD, Stanton AV, Jabbar AS, et al. Effect of antihypertensive treatment on retinal microvascular changes in hypertension[J].J Hypertens, 2008,26(8):1703-1707.
[6] Labat C, Lacolley P,Lajemi M,et al.Effects of valsartan on mechanical properties of the carotid artery in spontaneously hypertensive rats under high-salt diet[J].Hypertension,2001,38(3):439-443.
[7] 张 静,高 欢.依那普利对老年自发性高血压大鼠心功能和心室重构的改善作用[J].中国老年学杂志,2014,34(16):4616-4617.
[8] Zhao YH, Li BF, Dong SY, et al. A novel ACE inhibitory peptide isolated from Acaudina molpadioides hydrolysate[J].Peptides,2009,30(6):1028-1033.
[9] Hong F, Ming L, Yi S, et al. The antihypertensive effect of peptides: a novel alternative to drugs[J].Peptides,2008,29(6):1062-1071.
[10] Junling H, Ming L, Hong F, et al. Effects of angiotensin-converting enzyme inhibitory peptide LAP on vascular remodeling[J].Clin Exp Hypertens,2013,35(6):437-443.

备注/Memo

备注/Memo:
基金项目:上海市自然科学基金(10ZR1433200); 同济大学附属同济医院院级课题(TJ1505) 作者单位:200065 上海,同济大学附属同济医院老年科 通信作者:罗 明,Email:Lmfc84@126.com
更新日期/Last Update: 2016-09-20