|本期目录/Table of Contents|

[1]潘江其,于璐,唐鲜娥,等.白细胞介素1β和核因子κB相关免疫通路在冠状动脉粥样硬化性心脏病合并抑郁中的作用[J].国际心血管病杂志,2016,02:123-126.
　PAN Jiangqi,YU Lu,TANG Xian'e,et al.Study of immunologic relationship between depression and coronary artery disease[J].International Journal of Cardiovascular Disease,2016,02:123-126.
点击复制

白细胞介素1β和核因子κB相关免疫通路在冠状动脉粥样硬化性心脏病合并抑郁中的作用(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2016年02期
页码:
123-126
栏目:
临床研究
出版日期:
2016-03-20

文章信息/Info

Title:
Study of immunologic relationship between depression and coronary artery disease
作者:
潘江其; 于璐; 唐鲜娥; 马文林; 石炜祺; 邓良; 赵翠梅; 杨凡
200092上海,同济大学医学院(潘江其,于 璐,唐鲜娥); 200065上海,同济大学附属同济医院心内科
Author(s):
PAN Jiangqi1;  YU Lu1;  TANG Xian'e1;  MA Wenlin2;  SHI Weiqi2;  DENG Liang2;  ZHAO Cuimei2;  YANG Fan3.
关键词:
冠状动脉粥样硬化性心脏病; 抑郁; 白细胞介素-1β
Keywords:
Coronary artery disease;  Depression;  Interleukin-1β
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2016.02.017
文献标识码:
-
摘要:
目的:通过检测冠状动脉粥样硬化性心脏病(coronaryarterydisease,CAD)合并抑郁患者的免疫功能,探索疾病之间的免疫学关系。方法:连续收集173例CAD患者,运用患者健康量表-9(patienthealthquestionnaire-9,PHQ-9)对已确诊的CAD患者进行抑郁症状评估。根据PHQ-9评分将患者分为情绪正常组(0≤PHQ-9评分<5)、轻度抑郁组(5≤PHQ-9评分<10分)、中度抑郁组(10≤PHQ-9评分≤14分)、中重度及重度抑郁组(15≤PHQ-9评分
Abstract:
Objective: To explore the immunologic relationship between depression and coronary artery disease(CAD).Methods: A total of 175 patients were enrolled continuously, and were divided into 4 groups according to the scores of patient health questionnaire-9(P

参考文献/References

[1] Meijer A, Conradi HJ, Bos EH, et al. Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis of 25 years of research[J]. Gen Hosp Psychiatry,2011,33(3):203-216.
[2] Ma W, Hu D, Liu G, et al. Predictors of quality of life in Chinese patients with acute coronary syndrome[J]. Asian Cardiovasc Thorac Ann,2010,18(5):469-475.
[3] 马文林,徐 颖,李美婧,等. 急性冠脉综合征伴发焦虑抑郁情绪患者生活质量的研究[J]. 中华行为医学与脑科学杂志,2008,17(4):318-319.
[4] Raison CL, Capuron L, Miller AH. Cytokines sing the blues: inflammation and the pathogenesis of depression[J]. Trends Immunol,2006,27(1):24-31.
[5] Pan A, Lucas M, Sun Q, et al. Increased mortality risk in women with depression and diabetes mellitus[J]. Arch Gen Psychiatry,2011,68(1):42-50.
[6] Kroenke K, Spitzer RL, Williams J B. The PHQ-9: validity of a brief depression severity measure[J]. J Gen Intern Med,2001,16(9):606-613.
[7] Whooley MA, Wong JM. Depression and cardiovascular disorders[J]. Annu Rev Clin Psychol,2013,9(1):327-354.
[8] 刘德彬,孙晓宁,张振刚. 抑郁与缺血性心脏病[J]. 国际心血管病杂志,2007,34(2):129-132.
[9] 许晶晶. 焦虑抑郁情绪对冠心病患者血清炎症因子及血管内皮功能的影响[J]. 中国循环杂志,2011(06):426-429.
[10] Mazereeuw G, Herrmann N, Bennett SA, et al. Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms andneurodegeneration[J]. Neurosci Biobehav Rev,2013,37(8):1611-1621.
[11] Mommersteeg PM, Meeuwis SH, Denollet J, et al. C-reactive protein and fibrinogen in non-obstructive coronary artery disease as related to depressive symptoms and anxiety: findings from the TweeSteden Mild Stenosis Study(TWIST)[J]. J Psychosom Res,2014,77(5):426-429.
[12] Dowlati Y, Herrmann N, Swardfager W, et al. A meta-analysis of cytokines in major depression[J]. Biol Psychiatry,2010,67(5):446-457.
[13] Neznanov NG, Kozlova SN, Mazo GE,et al. Comorbidity of depressive disorders and coronary heart disease: general aspects of pathogenesis[J]. Zh Nevrol Psikhiatr Im S S Korsakova, 2015,115(5):20-26.
[14] Leo R, Di Lorenzo G, Tesauro M, et al. Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy [J]. J Clin Psychiatry, 2006,67(11):1760-1766.
[15] Tajfard M, Latiff LA, Rahimi HR, et al. Serum inflammatory cytokines and depression in coronary artery diseas[J]. Iran Red Crescent Med J, 2014,16(7):e17111.
[16] 刘 莹,吴爵非,刘 俭,等. 肿瘤坏死因子-α和白介素-1β对小鼠腹主动脉炎症反应及内皮P-选择素表达的影响[J]. 实用医学杂志,2010,26(20):3688-3691.
[17] 王 莹. 药物难治性抑郁形成的炎症机制研究[D]. 第四军医大学,2011.
[18] Lawson MA, Mccusker RH, Kelley KW. Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice[J]. J Neuroinflammation,2013,10(1):54.

备注/Memo

备注/Memo:
基金项目:上海市卫生局课题(20114322 ) 通信作者:马文林,Email:mawenlin@medmail.com.cn
更新日期/Last Update: 2016-03-20