|本期目录/Table of Contents|

[1]倪世宏,刘兴元,魏东,等.缺氧诱导因子1-α基因C1744T多态与先天性心脏病的相关性研究[J].国际心血管病杂志,2016,01:46-49.
　NI Shihong,LIU Xingyuan,WEI Dong,et al.Study on the association of the polymorphism of C1744T in the hypoxia-inducible factor 1-alpha gene with congenital heart disease[J].International Journal of Cardiovascular Disease,2016,01:46-49.
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缺氧诱导因子1-α基因C1744T多态与先天性心脏病的相关性研究(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2016年01期
页码:
46-49
栏目:
出版日期:
2016-01-20

文章信息/Info

Title:
Study on the association of the polymorphism of C1744T in the hypoxia-inducible factor 1-alpha gene with congenital heart disease
作者:
倪世宏; 刘兴元; 魏东; 杨奕清
200431 上海,复旦大学附属华山医院宝山分院儿科(倪世宏); 200065 上海,同济大学医学院附属同济医院儿科(刘兴元); 200040 上海,上海交通大学附属儿童医院儿科(魏 东); 200030 上海,上海交通大学附属胸科医院心血管研究室(杨奕清)
Author(s):
NI Shihong1;  LIU Xingyuan2;  WEI Dong3;  YANG Yiqing4.
1.Department of Pediatrics, Baoshan Branch of Huashan Hospital, Fudan University, Shanghai 200431, China; 2.Department of Pediatrics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China; 3.Department of Pediatrics, Children's Hos
关键词:
先天性心脏病; 遗传学; 基因多态性; 缺氧诱导因子
Keywords:
Congenital heart disease;  Genetics;  Gene polymorphism;  Hypoxia-inducible factor
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2016.01.014
文献标识码:
-
摘要:
目的:研究缺氧诱导因子1-α(hypoxia-induciblefactor1-alpha,HIF1α)基因C1744T多态与先天性心脏病(congenitalheartdisease,CHD)的关系。方法:入选CHD患儿110例(病例组)及无CHD儿童200名(对照组),收集其临床资料和血标本,使用基因组DNA纯化试剂盒抽提基因组DNA。通过聚合酶链反应扩增HIF1α基因的第12个外显子,应用DNA测序试剂盒在DNA测序仪上对扩增片段进行测序。统计分析HIF1α基因C1744T多态在病例组和对照组间的频
Abstract:
Objective: To study the association of the polymorphism C1744T in the hypoxia-inducible factor 1-alpha(HIF1α)gene with congenital heart disease(CHD).Methods: A total of 110 children with CHD(case group)and 200 children without CHD(control group)were recru

参考文献/References

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备注/Memo

备注/Memo:
基金项目:上海市宝山区自然科学基金(12-E-25) 作者单位:200431 上海,复旦大学附属华山医院宝山分院儿科(倪世宏); 200065 上海,同济大学医学院附属同济医院儿科(刘兴元); 200040 上海,上海交通大学附属儿童医院儿科(魏 东); 200030 上海,上海交通大学附属胸科医院心血管研究室(杨奕清) 通信作者:倪世宏,Email: ni_shihong@sina.com
更新日期/Last Update: 2016-01-20