|本期目录/Table of Contents|

[1]范永臻,黄河,吴名星,等.尼可地尔对稳定型心绞痛患者PCI术后冠状动脉微循环阻力指数的影响[J].国际心血管病杂志,2015,06:412-415.
　FAN Yongzhen,HUANG He,WU Mingxing,et al.Impact of nicorandil pre-treatment on index of microcirculatory resistance in patients with stable angina undergoing percutaneous coronary intervention[J].International Journal of Cardiovascular Disease,2015,06:412-415.
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尼可地尔对稳定型心绞痛患者PCI术后冠状动脉微循环阻力指数的影响(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2015年06期
页码:
412-415
栏目:
临床研究
出版日期:
2015-11-25

文章信息/Info

Title:
Impact of nicorandil pre-treatment on index of microcirculatory resistance in patients with stable angina undergoing percutaneous coronary intervention
作者:
范永臻; 黄河; 吴名星; 黄浩波; 彭辉兵; 谢立强; 刘元; 易文艳; 周丽; 陈海燕
411100 湖南省湘潭市中心医院心内科
Author(s):
FAN Yongzhen;  HUANG He;  WU Mingxing;  HUANG Haobo;  PENG Huibin;  XIE Liqiang;  LIU Yuan;  YI Wenyan;  ZHOU Li;  CHEN Haiyan.
Department of Cardiology,Xiangtan Central Hospital, Hunan Province 411000, China
关键词:
尼可地尔; 微循环阻力指数; 稳定型心绞痛; 经皮腔内冠状动脉介入术
Keywords:
Nicorandil;  Index of microcirculatory resistance;  Stable angina;  Percutaneous coronary intervention
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2015.06.012
文献标识码:
-
摘要:
目的:探讨稳定型心绞痛患者口服尼可地尔对冠状动脉微循环阻力指数(IMR)影响。方法:入选以稳定型心绞痛入院并拟行择期经皮腔内冠状动脉介入术(PCI)的患者50例,加拿大心脏病学会的劳力性心绞痛分级<Ⅳ级。将患者随机分为尼可地尔组(n=25)和对照组(n=25),在择期PCI术前均常规使用双联抗血小板、他汀类药物和其他治疗冠心病相关药物。尼可地尔组口服尼可地尔5mg、3次/d,30d;对照组口服硝酸异山梨酯5mg、3次/d,30d。在行PCI术后,立刻以压力导丝检测两组患者
Abstract:
Objective:To assess the impact of nicorandil pre-treatment on the index of microcirculatory resistance(IMR)values in patients with stable angina pectoris undergoing percutaneous coronary intervention(PCI). Methods:A total of 50 consecutive patients with s

参考文献/References

[1] Camici PG, Crea F. Coronary microvascular dysfunction[J]. N Engl J Med,2007,356(8):830-840.
[2] Fujii K, Kawasaki D, Oka K, et al. The impact of pravastatin pre-treatment on periprocedural microcirculatory damage in patients undergoing percutaneous coronary intervention[J]. JACC: Cardiovasc Interv, 2011,4(5):513-520.
[3] 沈卫峰, 朱天奇. 改善急性 STEMI 直接 PCI 时冠脉微循环灌注[J]. 国际心血管病杂志, 2012,38(6):326-330.
[4] Pasceri V, Patti G, Nusca A, et al. Randomized trial of atorvastatin for reduction of myocardial damage during coronary intervention: results from the ARMYDA(Atorvastatin for Reduction of MYocardial Damage during Angioplasty)study[J]. Circulation, 2004,110(6):674-678.
[5] Sugimoto K, Ito H, Iwakura K, et al. Intravenous nicorandil in conjunction with coronary reperfusion therapy is associated with better clinical and functional outcomes in patients with acute myocardial infarction[J]. Circ J, 2003,67(4):295-300.
[6] Shehata M. Cardioprotective effects of oral nicorandil use in diabetic patients undergoing elective percutaneous coronary intervention[J]. J Interv Cardiol,2014,27(5):472-481.
[7] Aarnoudse W, Fearon WF, Manoharan G, et al. Epicardial stenosis severity does not affect minimal microcirculatory resistance[J]. Circulation,2004,110(15):2137-2142.
[8] Fiarresga A, Selas M, Oliveira E, et al. Invasive assessment of the coronary microcirculation using the index of microcirculatory resistance: Description and validation of an animal model[J]. Rev Port Cardiol,2014,33(4):207-212.
[9] Ng MK, Yeung AC, Fearon WF, et al. Invasive assessment of the coronary microcirculation superior reproducibility and less hemodynamic dependence of index of microcirculatory resistance compared with coronary flow reserve[J]. Circulation, 2006,113(17):2054-2061.
[10] Pijls NH, de Bruyne B, Peels K, et al. Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses[J]. N Engl J Med,1996,334(26):1703-1708.
[11] Fearon WF, Balsam LB, Farouque HO, et al. Novel index for invasively assessing the coronary microcirculation[J]. Circulation,2003,107(25):3129-3132.
[12] De Bruyne B, Pijls NH, Kalesan B, et al. Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease[J]. N Engl J Med,2012,367(11):991-1001.
[13] Pepine CJ, Douglas PS. Rethinking stable ischemic heart disease: is this the beginning of a new era?[J].J Am Coll Cardiol,2012,60(11):957-959.
[14] Marzilli M, Merz CNB, Boden WE, et al. Obstructive coronary atherosclerosis and ischemic heart disease: an elusive link[J]. J Am Coll Cardiol,2012,60(11):951-956.
[15] 周宏林, 陈晓敏, 王胜煌. 冠状动脉慢血流现象研究进展[J]. 国际心血管病杂志,2009,36(6):339-341.
[16] Jespersen L, Hvelplund A, Abildstrøm SZ, et al. Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events[J]. Eur Heart J,2012,33(6):734-744.
[17] Fearon WF, Low AF, Yong AS, et al. Prognostic value of the Index of Microcirculatory Resistance measured after primary percutaneous coronary intervention[J]. Circulation, 2013,127(24):2436-2441.
[18] Melikian N, Vercauteren S, Fearon WF, et al. Quantitative assessment of coronary microvascular function in patients with and without epicardial atherosclerosis[J]. EuroIntervention, 2010, 5(8):939-945.
[19] Murakami M, Iwasaki K, Kusachi S, et al. Nicorandil reduces the incidence of minor cardiac marker elevation after coronary stenting[J]. J Interv Cardiol,2006,107(1):48-53.

备注/Memo

备注/Memo:
基金项目:湖南省科技厅资助科研项目(2012SK3028); 湖南省卫生厅资助项目(B2013-138) 作者单位:411100 湖南省湘潭市中心医院心内科 通信作者:黄 河,Email:hh13607327390@126.com
更新日期/Last Update: 2015-12-20