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《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:

2024年06期

页码:

379-384

栏目:

基础研究

出版日期:

2024-12-10

文章信息/Info

Title:

Role of miR-129-5p in sepsis-induced cardiac inflammation and dysfunction

作者:

华云峰; 杨珺; 余娜

210036 南京，江苏卫生健康职业学院临床医学院（华云峰）；213376 江苏省人民医院溧阳分院消化内科（杨珺）；214023 南京医科大学附属无锡人民医院超声医学科（余娜）

Author(s):

HUA Yunfeng¹;  YANG Jun²;  YU Na³.

1. School of Clinical Medicine, Jiangsu College of Health Professions, Nanjing? 210036; 2. Department of Gastroenterology, Liyang Branch, Jiangsu Provincial People's Hospital, Liyang? 213376; 3. Department of Ultrasound Medicine, Wuxi People's H

关键词:

miR-129-5p ; PAX6/ZEB2信号通路; 脓毒症

Keywords:

MiR-129-5p;  PAX6/ZEB2 signaling pathway;  Sepsis

分类号:

-

DOI:

10.3969/j.issn.1673-6583.2024.06.014

文献标识码:

-

摘要:

目的：探讨miR-129-5p在脓毒症诱导的心脏炎症和功能障碍中的作用。方法：24只8周龄的C57/BL6雄性小鼠按随机数字表法随机分为正常（Normal）组、脂多糖（LPS）组、LPS＋空病毒对照（minic-NC）组、LPS＋miR-129-5p慢病毒（miR-129-5pminic）组，每组6只，采用腹腔注射LPS建立脓毒症小鼠模型。采用免疫组织化学染色检测配对盒基因6（PAX6），全自动生化分析仪检测血清肌酸激酶（CK）、肌酸激酶同工酶（CK-MB），TUNEL分析检测心肌凋亡情况。体外采用LPS

Abstract:

Objective: This study aimed to assess the role of miR-129-5p expression in sepsis-induced cardiac inflammation and dysfunction.? Methods: Twenty-four 8-week-old C57/BL6 male mice were randomly divided into 4 groups, including normal group, lipopolysacchar

参考文献/References

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备注/Memo

备注/Memo:

基金项目：江苏省高等学校基础科学研究（21KJB400152）
通信作者：华云峰，E-mail：afbbmu01@163.com

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更新日期/Last Update: 2024-12-10