|本期目录/Table of Contents|

[1]聂雅琴,乌日娜,金慧,等.高迁移率族蛋白1通过调控自噬因子P62调节心肌细胞纤维化[J].国际心血管病杂志,2024,02:109-113.
　NIE Yaqin,WU Rina,JIN Hui,et al.HMGB1 induces myocardial fibrosis by regulating autophagy factor P62[J].International Journal of Cardiovascular Disease,2024,02:109-113.
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高迁移率族蛋白1通过调控自噬因子P62调节心肌细胞纤维化(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2024年02期
页码:
109-113
栏目:
基础研究
出版日期:
2024-03-25

文章信息/Info

Title:
HMGB1 induces myocardial fibrosis by regulating autophagy factor P62
作者:
聂雅琴; 乌日娜; 金慧; 张广平; 李永明; 智利; 薛仕煊; 娜日格乐
014040 包头医学院中心临床医学院（聂雅琴）；014040 包头市中心医院心血管内科（乌日娜，金慧，张广平， 李永明， 智利， 薛仕煊， 娜日格乐）
Author(s):
NIE Yaqin1;  WU Rina2;  JIN Hui2;  ZHANG Guangping2;  LI Yongming2;  ZHI Li2;  XUE Shixuan2;  NARI Gele2
1.Baotou Medical College Center Clinical Medical College, Baotou 014040; 2.Cardiovascular Department of Baotou Central Hospital, Baotou? 014040, China
关键词:
高迁移率族蛋白1 ; AC16细胞; 自噬; 心肌纤维化
Keywords:
High mobility group protein;  AC16 cells;  Autophagy;  Myocardial fibrosis
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2024.02.012
文献标识码:
-
摘要:
目的：探究高迁移率族蛋白1（HMGB1）通过调控自噬活性对心肌纤维化的影响及作用机制。方法：将人心肌细胞AC16培养于DMEM培养基中，用不同浓度的HMGB1（0、4、20、100μg/L）干预AC16细胞6h，免疫荧光染色检测心脏成纤维细胞活化的标志性蛋白α平滑肌肌动蛋白（α-SMA）的表达水平，Westernblot法检测心肌自噬相关蛋白哺乳动物雷帕霉素靶蛋白（mTOR）、磷酸化mTOR（p-mTOR）、微管相关蛋白1轻链3（LC3）、磷酸肌醇-3-激酶3（PIK3C3）、可溶性及不可溶性P62、α-
Abstract:
Objective: To explore the effect of high mobility group box protein 1 (HMGB1) on myocardial fibrosis by regulating autophagy activity of human cardiomyocytes (AC16) and its possible mechanism.? Methods：AC16 cells were cultured in DMEM medium and treated w

参考文献/References

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备注/Memo

备注/Memo:
基金项目：内蒙古医科大学科技百万工程联合项目[YKD2020KJBW(LH)065]
通信作者：乌日娜， E-mail：46505898@qq.com
更新日期/Last Update: 2024-03-25