|本期目录/Table of Contents|

[1]丁佳慧,吴建江,程虎,等.过表达解偶联蛋白2抑制氧化应激减轻糖尿病 小鼠心肌缺血再灌注损伤[J].国际心血管病杂志,2024,01:53-58.
　DING Jiahui,WU Jianjiang,CHENG Hu,et al.Overexpression of UCP2 alleviates myocardial ischemia-reperfusion injury by inhibiting oxidative stress in diabetic mice[J].International Journal of Cardiovascular Disease,2024,01:53-58.
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过表达解偶联蛋白2抑制氧化应激减轻糖尿病 小鼠心肌缺血再灌注损伤(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2024年01期
页码:
53-58
栏目:
基础研究
出版日期:
2024-01-22

文章信息/Info

Title:
Overexpression of UCP2 alleviates myocardial ischemia-reperfusion injury by inhibiting oxidative stress in diabetic mice
作者:
丁佳慧; 吴建江; 程虎; 朱阔; 于文彬; 王江
830011 乌鲁木齐， 新疆医科大学第一附属医院麻醉科
Author(s):
DING Jiahui;  WU Jianjiang;  CHENG Hu;  ZHU Kuo;  YU Wenbin; WANG Jiang
Department of Anesthesiology，The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China
关键词:
解偶联蛋白2 ; 心肌再灌注损伤; 糖尿病; 氧化应激
Keywords:
Uncoupling protein 2;  Myocardial reperfusion injury;  Diabetes mellitus;  Oxidative stress
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2024.01.015
文献标识码:
-
摘要:
目的：探讨过表达解偶联蛋白2（UCP2）减轻糖尿病小鼠心肌缺血再灌注损 伤（IRI）的机制。方法：60 只8 周龄C57BL 小鼠高脂喂养6 周后，注射链脲佐菌素建立 小鼠糖尿病模型，采用随机数字表法分为5 组，假手术组（Sham 组）、缺血再灌注组（I/R 组）、UCP2 抑制剂组（Genipin 组）、空载9 型腺相关病毒（AAV9-NC）组（AN 组）和携 带UCP2 基因的AAV9 组（AU 组），每组12 只。Sham 组仅切开皮肤后缝合，其余4 组开 胸结扎冠状动脉左前降支，缺血60 min
Abstract:
Objective：To investigate whether overexpression of uncoupling protein 2 (UCP2) alleviates myocardial ischemia-reperfusion injury (IRI) by inhibiting oxidative stress in diabetic mice. Methods：Sixty 8-week-old SPF C57BL mice were fed with high fat diet and

参考文献/References

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金项目（81960053）
通信作者：王江， E-mail：523903512@qq.com
更新日期/Last Update: 2024-01-22