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《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:

2023年01期

页码:

41-45

栏目:

基础研究

出版日期:

2023-01-20

文章信息/Info

Title:

The protective role of salvianolic acid A on cardiac function in mice after resuscitation from cardiac arrest

作者:

曹维锷; 樊子旭; 郑宏超; 李艳杰; 吉庆起

200031 上海市徐汇区中心医院急诊科（曹维锷），心内科（樊子旭，郑宏超，李艳杰）；200080 上海交通 大学附属第一人民医院心内科（吉庆起）

Author(s):

CAO Weie¹;  FAN Zixu²;  ZHENG Hongchao²;  LI Yanjie²;  JI Qingqi³

1. Department of Emergency, Shanghai Xuhui District Central Hospital, Shanghai 200031; 2. Department of Cardiology, Shanghai Xuhui District Central Hospital, Shanghai 200031; 3. Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong Unive

关键词:

丹酚酸A ; 心脏骤停; 心功能; 炎性反应

Keywords:

Salvianolic acid A;  Cardiac arrest;  Cardiac function;  Inflammatory response

分类号:

-

DOI:

10.3969/j.issn.1673-6583.2023.01.011

文献标识码:

-

摘要:

目的：探讨丹酚酸A（Sal A）对小鼠心肺复苏（CPR）后心功能的作用。 方法： 24 只雌性C57BL/6 小鼠随机分为3 组，对照组小鼠不进行建模，实验组小鼠通过颈静脉注射 氯化钾建立CPR 模型，CPR 后30 s 给予注射Sal A（15 mg/kg）（Sal A 组）和等体积生理 盐水（Vehicle 组），超声心动图分析小鼠左室射血分数和左室缩短分数，血流动力学仪器监 测3 h 内心脏血流动力学变化，并统计72 h 内小鼠生存率。Western blot 分析CPR 后3 h 心 肌炎性因子白

Abstract:

Objective: To investigate the effect of salvianolic acid A (Sal A) on cardiac function in mice after cardiopulmonary resuscitation (CPR). Methods: Twenty-four female C57BL/6 mice were randomly divided into 3 group. The control group was not treated. Other

参考文献/References

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备注/Memo

备注/Memo:

基金项目：国家自然科学基金（82100271）；上海科技创新行动计划启明星项目（22YF1443000）
通信作者：吉庆起， E-mail：lsyzjqq@hotmail.com

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更新日期/Last Update: 2023-01-20