索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]郑丽婷,游紫阳,冯莉,等.瞬时受体电位通道A1 亚型在冠状动脉粥样硬化性心脏病中的临床研究进展[J].国际心血管病杂志,2022,06:344-346.
点击复制

瞬时受体电位通道A1 亚型在冠状动脉粥样硬化性心脏病中的临床研究进展(PDF)

《国际心血管病杂志》[ISSN:1006-6977/CN:61-1281/TN]

期数:
2022年06期
页码:
344-346
栏目:
综述
出版日期:
2022-12-20

文章信息/Info

Title:
-
作者:
郑丽婷; 游紫阳; 冯莉; 林万鹏; 杨骄霞
157011 牡丹江医学院（郑丽婷，游紫阳，冯莉，林万鹏）； 157011 牡丹江医学院附属红旗医院心血管内科（杨骄霞）
Author(s):
-
关键词:
冠状动脉粥样硬化性心脏病; 瞬时受体电位通道A1 亚型; 缺血再灌注损伤;  动脉粥样硬化
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-6583.2022.06.007
文献标识码:
-
摘要:
瞬时受体电位通道A1 亚型（TRPA1）是存在于细胞膜上的非选择性阳离子通 道锚蛋白。TRPA1 可能降低心肌再灌注损伤，TRPA1 抑制剂在心血管系统中也发挥一定的 作用。该文主要介绍TRPA1 基本结构、功能、检测方法，TRPA1 与冠状动脉粥样硬化性心 脏病发病的相关性研究，TRPA1 在心肌缺血再灌注损伤中的研究现状和相关治疗。
Abstract:
-

参考文献/References

[1] 郭建华, 李艳玲. 氯吡格雷治疗老年冠心病的研究进展[J]. 老年医学与保健, 2021, 27(4):892-896.
[2] 王震, 刘剑芳, 王梦龙, 等. 瞬时受体电位通道A1在压力负 荷致心肌肥厚小鼠的表达及意义[J]. 中华老年心脑血管病 杂志, 2018, 20(8):858-861.
[3] Wang Z, Ye D, Ye J, et al. The TRPA1 Channel in the cardiovascular system:promising features and challenges[J], Front Pharmacol, 2019, 10:1253.
[4] Dalenogare DP, Ritter C, Bellinaso FRA, et al. Periorbital nociception in a progressive multiple sclerosis mouse model is dependent on TRPA1 Channel activation[J]. Pharmaceuticals (Basel), 2021, 14(8):831.
[5] Inoue R, Kurahara LH, Hiraishi K. TRP channels in cardiac and intestinal fibrosis[J]. Semin Cell Dev Biol, 2019, 94:40-49.
[6] 卜凡洁, 张彦青, 解军波. TRPA 1离子通道及其功能研究进 展[J]. 中国现代应用药学, 2021, 38(13):1618-1626.
[7] 杨震, 谢洪祥, 吴奇, 等. TRPA1在冠心病患者外周血单核细 胞中的表达及其与冠状动脉病变程度的相关性研究[J]. 临 床心血管病杂志, 2018, 34(11):1073-1076.
[8] Liu D, Sun M, Xu D, et al. Inhibition of TRPA1 and IL-6 signal alleviates neuropathic pain following chemotherapeutic bortezomib[J]. Physiol Res, 2019, 68(5):845-855.
[9] Gu X, Yu N, Pang X, et al. Express: products of oxidative stress and TRPA1 expression in the brainstem of rats after lung ischemia-reperfusion injury[J]. Pulm Circ, 2019, 9(3): 2045894019865169.
[10] Yang X, Li Y, Li Y, et al. Oxidative Stress-Mediated atherosclerosis:mechanisms and therapies[J]. Front Physiol, 2017, 8:600.
[11] Wang M, Zhang Y, Xu M, et al. Roles of TRPA1 and TRPV1 in cigarette smoke -induced airway epithelial cell injury model[J]. Free Radic Biol Med, 2019, 134:229-238.
[12] 王震. TRPA1在心肌肥厚中的作用及其机制研究[Z]. 武汉: 武汉大学, 2019:52.
[13] Herrmann AK, Wüllner V, Moos S, et al. Dimethyl fumarate alters intracellular Ca2+ handling in immune cells by redoxmediated pleiotropic effects[J]. Free Radic Biol Med, 2019, 141:338-347.
[14] Miao F, Wang R, Cui G, et al. Engagement of microRNA-155 in exaggerated oxidative stress signal and TRPA1 in the dorsal horn of the spinal cord and neuropathic pain during chemotherapeutic oxaliplatin[J]. Neurotox Res, 2019, 36(4): 712-723.
[15] Li R, Liu R, Yan F, et al. Inhibition of TRPA1 promotes cardiac repair in mice after myocardial infarction[J]. J Cardiovasc Pharmacol, 2020, 75(3):240-249.
[16] 谢果, 陈伟, 王海英. 金属硫蛋白在心肌缺血/再灌注损伤 中保护作用的研究进展[J]. 国际麻醉学与复苏杂志, 2021, 42(9):1004-1008.
[17] Sheriff A, Kayser S, Brunner P, et al. C-reactive protein triggers cell death in ischemic cells[J]. Front Immunol, 2021, 12:630430.
[18] 赵丹, 王沛坚, 周鹏. TRPA1/TRPV1在心血管疾病中的作用 [J]. 成都医学院学报, 2019, 14(6):819-822.
[19] Conklin DJ, Guo Y, Nystoriak MA, et al. TRPA1 Channel contributes to myocardial ischemia-reperfusion injury[J]. Am J Physiol Heart Circ Physiol, 2019, 316(4):H889-H899.
[20] Kozai D, Sakaguchi R, Ohwada T, et al. Deciphering subtypeselective modulations in TRPA1 biosensor channels[J]. Curr Neuropharmacol, 2015, 13(2):266-278.
[21] McNamara CR, Mandel-Brehm J, Bautista DM, et al. TRPA1 mediates formalin-induced pain[J]. Proc Natl Acad Sci U S A, 2007, 104(33):13525-13530.
[22] Andrade EL, Forner S, Bento AF, et al. TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury[J]. Am J Physiol Renal Physiol, 2011, 300(5):F1223-F1234.
[23] Dalenogare DP, Theisen MC, Peres DS, et al. TRPA1 activation mediates nociception behaviors in a mouse model of relapsing-remitting experimental autoimmune encephalomyelitis[J]. Exp Neurd, 2020, 328:113241.
[24] de Almeida AS, Rigo FK, De Prá SD, et al. Role of transient receptor potential ankyrin 1(TRPA1) on nociception caused by a murine model of breast carcinoma[J]. Pharmacol Res, 2020, 152:104576.
[25] Bousquet J, Czarlewski W, Zuberbier T, et al. Potential interplay between Nrf2, TRPA1, and TRPV1 in nutrients for the control of COVID-19[J]. Int Arch Allergy Immunol, 2021, 182(4):324-338.
[26] Wu Y, Chen AW, Goodnough CL, et al. IcyHot analgesic topical cream limits cardiac injury in rodents[J]. Transl Res, 2021, 227:42-52.
[27] GONG H, LI Y, FENG L, et al.Yanghe decoction (阳和汤) attenuated pain hypersensitivity induced by michigan cancer foundation-7 injection in rats with bone metastases from breast cancer by inhibiting transient receptor potential ankyrin 1[J/OL]. Journal of Traditional Chinese Medicine. http://doi. org/10.19852/j.cnki.jtcm.20220707.001.
[28] 李相萱, 彭家芹. 心脏康复与心血管疾病的研究进展[J]. 中 国老年学杂志, 2021, 41(16):3629-3632.

备注/Memo

备注/Memo:
通信作者：杨骄霞， E-mail：jiaoxiayang1977@163.com
更新日期/Last Update: 2022-12-20